核基质蛋白21抗体

Quantity size:

0.2ml

Concentration:

1mg/ml 核基质蛋白21抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase 核基质蛋白21抗体transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Also plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7 during early steps of apoptosis: the C-terminal 64 kDa cleavage product may act as a nuclear signal to initiate cytoplasmic events involved in the apoptotic pathway.

核基质蛋白21抗体Also known as:

Double-strand-break repair protein rad21 homolog; hHR21; HR21; HRAD21; MCD1; Nuclear matrix protein 1; NXP-1; NXP1; RAD21; RAD21 homolog; RAD21_HUMAN; Scc1; SCC1 homolog; FLJ25655; FLJ40596; KIAA0078; SCC1.

Specificity:

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Rabbit Polyclonal IgG, 核基质蛋白21抗体affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, .

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Immunogen: KLH conjugated synthetic peptide derived from human Rad2.

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Predicted Molecular Weight: 69kDa.

核基质蛋白21抗体Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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