磷酸化Rho GTP酶激活蛋白1/血管畸形骨肥大综合征相关蛋白抗体

Quantity size:

0.1ml

Concentration:

1mg/ml 磷酸化Rho GTP酶激活蛋白1/血管畸形骨肥大综合征相关蛋白抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

The mammalian c-H-, c-K- and N-Ras proto-oncogenes encode ubiquitously expressed proteins (1,2). p21Ras can exist in either a physiologically quiescent GDP-binding state or a GTP-binding signal-emitting state (3). Oncogenic p21Ras proteins are trapped in the excited signal-emitting state because the mechanism normally employed to delimit their excitation period, hydrolysis of their bound GTP to GDP, is impaired as a result of specific磷酸化Rho GTP酶激活蛋白1/血管畸形骨肥大综合征相关蛋白抗体  mutations (3). Interaction of p21Ras with GTPase activating protein (GAP) can increase hydrolysis of p21Ras-bound GTP by as much as 1000-fold (4,5). The product of the neurofibromatosis type 1 gene (NF1) has also been shown to exhibit p21Ras GAP activity (6,7), and proteins that stimulate the GTPase activity of three other low molecular weight GTPases, including Rho, Rab 3A and Rap 1, have also been described (8,9).

磷酸化Rho GTP酶激活蛋白1/血管畸形骨肥大综合征相关蛋白抗体 Also known as:

GAP (phospho Y460); p-GAP (phospho Y460); Ras GAP; CM AVM; CMAVM; DKFZp434N071; GAP; GTPase activating protein; GTPase-activating protein; OTTHUMP00000222390; OTTHUMP00000222391; OTTHUMP00000222392; OTTHUMP00000222393; p120GAP; p120RASGAP; PKWS; Ras GTPase-activating protein 1; RAS p21 protein activator (GTPase activating protein) 1; Ras p21 protein activator; 磷酸化Rho GTP酶激活蛋白1/血管畸形骨肥大综合征相关蛋白抗体 RASA; RASA1; RASA1_HUMAN; RasGAP; Triphosphatase activating protein.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, .

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Immunogen: KLH conjugated synthesised phosphopeptide derived from human GAP around the phosphorylation site of Tyr460.

磷酸化Rho GTP酶激活蛋白1/血管畸形骨肥大综合征相关蛋白抗体 ●

Predicted Molecular Weight: 116kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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