磷酸化SH2结构域转化蛋白1抗体

Quantity size:

0.1ml

Concentration:

1mg/ml 磷酸化SH2结构域转化蛋白1抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species.磷酸化SH2结构域转化蛋白1抗体 The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

磷酸化SH2结构域转化蛋白1抗体Also known as:

SHC (phospho Tyr239 + Tyr240); SHC (phospho Y239 + Y240); p-SHC (Tyr239 + Tyr240); p-SHC (Y239 + Y240); p46; p52; p52 SHC; p52SHC; p66; p66 SHC; p66SHC; SH2 domain protein C1; SHC (Src homology 2 domain containing) transforming protein 1; SHC 1; SHC A; Shc; SHC transforming protein 1; SHC transforming protein; SHC1; SHCA; Src homology 2 domain containing transforming protein C1.

Specificity:

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Rabbit Polyclonal IgG,磷酸化SH2结构域转化蛋白1抗体 affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Dog, Pig, Cow, Horse, .

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磷酸化SH2结构域转化蛋白1抗体Immunogen: KLH conjugated Synthesised phosphopeptide derived from human SHC around the phosphorylation site of Tyr239/240.

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Predicted Molecular Weight: 41kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user

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