磷酸化沉默调节相关蛋白6抗体

Quantity size:

0.1ml

Concentration:

1mg/ml  磷酸化沉默调节相关蛋白6抗体 Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

NAD-dependent protein deacetylase. Has deacetylase activity towards 'Lys-9' and 'Lys-56' of histone H3. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates 'Lys-9' of histone H3 at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Deacetylation磷酸化沉默调节相关蛋白6抗体 of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. Regulates the production of TNF protein.

磷酸化沉默调节相关蛋白6抗体Also known as:

SIRT6(phospho S338); 2810449N18Rik; AI043036; Mono ADP ribosyltransferase sirtuin 6; NAD-dependent deacetylase sirtuin-6; NAD-dependent protein deacetylase sirtuin-6; SIR2 like 6; SIR2 like protein 6; Sir2 related protein type 6; SIR2-like protein 6; SIR2L6; SIRT 6; SIRT6; SIR6_HUMAN; Sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae)磷酸化沉默调节相关蛋白6抗体; Sirtuin 6; Sirtuin type 6; Sirtuin6.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, .

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Immunogen: KLH conjugated synthesised phosphopeptide derived from human SIRT6 around the phosphorylation site of Ser338.

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Predicted Molecular Weight: 39kDa.

磷酸化沉默调节相关蛋白6抗体Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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