磷酸化认知缺陷突触相关蛋白SynGAP抗体

Quantity size:

0.1ml

Concentration:

1mg/ml 磷酸化认知缺陷突触相关蛋白SynGAP抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

The PSD-95/SAP 90 family of proteins, which are known to bind to and cluster various membrane proteins, are involved in the organization of synaptic structure. SynGAP (for synaptic GTPase activating protein), a novel synaptic RasGAP, is a brain-specific protein abundant磷酸化认知缺陷突触相关蛋白SynGAP抗体 in the cortex, hippocampus and olfactory bulb. SynGAP interacts with all three PDZ domains within PSD-95/ SAP 90 proteins. It represents one of three classes of mammalian RasGAPs and is specifically localized to excitatory synapses possessing NMDA receptors. SynGAP may be involved in the regulation of BDNF as well as Ras signaling. Its activity is inhibited by phosphorylation by CaMKII, which could result in the activation of the MAP kinase pathway.

磷酸化认知缺陷突触相关蛋白SynGAP抗体Also known as:

SynGAP (phospho S836); SynGAP (phospho Ser836); p-SynGAP (Ser836); p-RASA1(Ser836); Neuronal RasGAP; p135 SynGAP; Ras GTPase activating protein SynGAP; Ras GTPase-activating protein SynGAP; RASA 1; RASA 5; RASA1; RASA5; SYGP1_HUMAN; Synaptic Ras GAP 1; Synaptic Ras GTPase activating protein 1; Synaptic Ras GTPase activating protein 1 homolog; Synaptic Ras 磷酸化认知缺陷突触相关蛋白SynGAP抗体GTPase activating protein 135kDa; synaptic Ras GTPase activating protein; Synaptic Ras GTPase-activating protein 1; Synaptic Ras-GAP 1; SYNGAP 1; SYNGAP1; DKFZp761G1421; KIAA1938; MRD5; OTTHUMP00000064825.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Pig, Horse, Rabbit, .

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Immunogen: KLH conjugated synthesised phosphopeptide derived from human SynGAP around the phosphorylation site of Ser836.

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Predicted Molecular Weight: 148kDa.

磷酸化认知缺陷突触相关蛋白SynGAP抗体Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user

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