磷酸化细胞信号转导分子SMAD2抗体

Quantity size:

0.1ml

Concentration:

1mg/ml 磷酸化细胞信号转导分子SMAD2抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular磷酸化细胞信号转导分子SMAD2抗体 processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus,磷酸化细胞信号转导分子SMAD2抗体 where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]

磷酸化细胞信号转导分子SMAD2抗体Also known as:

Smad2 (phospho S250); p-Smad2 (phospho S250); hMAD 2; hMAD 3; hSMAD2; hSMAD3; Mad related protein 2; MADH2; MADH3; MADR2; Mothers against DPP homolog 2; Mothers against DPP homolog 3; Sma and Mad related protein 2; SMA and MAD related protein 3; SMAD 2; SMAD 3; SMAD family member 2; SMAD family member 3.

Specificity:

●

Rabbit Polyclonal IgG, affinity purified by Protein A.

●

Reacts with: Human, Mouse, Rat, Dog, Pig, Cow, .

●

Immunogen: KLH conjugated synthesised phosphopeptide derived from human Smad2 around the phosphorylation site of Ser250.

●

Predicted Molecular磷酸化细胞信号转导分子SMAD2抗体 Weight: 58kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user

kl106Hu01骨成型蛋白10(BMP10)多克隆抗体Polyclonal Antibody to Bone Morphogenetic Protein 10 (BMP10)

kl106Mu01骨成型蛋白10(BMP10)多克隆抗体Polyclonal Antibody to Bone Morphogenetic Protein 10 (BMP10)

kl107Hu01骨形成蛋白15(BMP15)多克隆抗体Polyclonal Antibody to Bone Morphogenetic Protein 15 (BMP15)

kl108Hu01生长分化因子1(GDF1)多克隆抗体Polyclonal Antibody to Growth Differentiation Factor 1 (GDF1)

kl109Mu01生长分化因子3(GDF3)多克隆抗体Polyclonal Antibody to Growth Differentiation Factor 3 (GDF3)

kl109Ra01生长分化因子3(GDF3)多克隆抗体Polyclonal Antibody to Growth Differentiation Factor 3 (GDF3)

kl110Hu01生长分化因子5(GDF5)多克隆抗体Polyclonal Antibody to Growth Differentiation Factor 5 (GDF5)

kl113Mu01生长分化因子11(GDF11)多克隆抗体Polyclonal Antibody to Growth Differentiation Factor 11 (GDF11)

kl123Hu01Smad同源物3(Smad3)多克隆抗体Polyclonal Antibody to Mothers Against Decapentaplegic Homolog 3 (Smad3)

kl123Ra01Smad同源物3(Smad3)多克隆抗体Polyclonal Antibody to Mothers Against Decapentaplegic Homolog 3 (Smad3)

kl124Mu01Smad同源物2(Smad2)多克隆抗体Polyclonal Antibody to Mothers Against Decapentaplegic Homolog 2 (Smad2)

kl125Hu01Cerberus蛋白(CER)多克隆抗体Polyclonal Antibody to Cerberus (CER)

kl126Ra01腱蛋白(CHRD)多克隆抗体Polyclonal Antibody to Chordin (CHRD)

kl127Hu01核心蛋白聚糖(DCN)多克隆抗体Polyclonal Antibody to Decorin (DCN)

kl128Hu01Gremlin 1蛋白(GREM1)多克隆抗体Polyclonal Antibody to Gremlin 1 (GREM1)

kl128Mu01Gremlin 1蛋白(GREM1)多克隆抗体Polyclonal Antibody to Gremlin 1 (GREM1)

kl130Hu01头蛋白(NOG)多克隆抗体Polyclonal Antibody to Noggin (NOG)

kl130Mu01头蛋白(NOG)多克隆抗体Polyclonal Antibody to Noggin (NOG)

kl130Ra01头蛋白(NOG)多克隆抗体Polyclonal Antibody to Noggin (NOG)

kl135Hu01ⅩⅦ型胶原(COL17)多克隆抗体Polyclonal Antibody to Collagen Type XVII (COL17)

kl137Hu01ⅩⅤ型胶原(COL15)多克隆抗体Polyclonal Antibody to Collagen Type XV (COL15)

kl137Mu01ⅩⅤ型胶原(COL15)多克隆抗体Polyclonal Antibody to Collagen Type XV (COL15)

kl138Hu01ⅩⅢ型胶原(COL13)多克隆抗体Polyclonal Antibody to Collagen Type XIII (COL13)

kl143Hu01Ⅳ型胶原α3(COL4α3)多克隆抗体Polyclonal Antibody to Collagen Type IV Alpha 3 (COL4a3)

kl145Ra01Ⅸ型胶原α1(COL9α1)多克隆抗体Polyclonal Antibody to Collagen Type IX Alpha 1 (COL9a1)

kl146Hu01Ⅷ型胶原α1(COL8α1)多克隆抗体Polyclonal Antibody to Collagen Type VIII Alpha 1 (COL8a1)

kl147Hu01Ⅶ型胶原(COL7)多克隆抗体Polyclonal Antibody to Collagen Type VII (COL7)

kl147Mu01Ⅶ型胶原(COL7)多克隆抗体Polyclonal Antibody to Collagen Type VII (COL7)