供货周期: | 现货 |
品牌: | 康朗生物 |
规格: | 0.1ml/0.2ml |
货号: | KL20151R |
CAS号: |
Quantity size:
0.2ml
Concentration:
1mg/ml 信号转导和转录激活因子7抗体 Buffer = Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
Background:
The eight members of the recently identified Suppressor of Cytokines Signaling (SOCS) family are SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS6, SOCS7, and CIS. Structurally the SOCS proteins are composed of an N- terminal region of variable length and amino acid composition, a central SH2 domain, and a C-terminal motif called the SOCS box. The SOCS proteins appear to form part of a classical negative feedback loop that regulates 信号转导和转录激活因子7抗体 cytokine signal transduction. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. SOCS1 and SOCS6 interact with the insulin receptor (IR) when expressed in human hepatoma cells (HepG2) or in rat hepatoma cells overexpressing human IR. SOCS1 and SOCS6 inhibit insulin-dependent activation of ERK1/2 and protein kinase B in vivo and IR- directed phosphorylation of IRS1 in vitro. These results suggest that SOCS proteins may be inhibitors of IR signalling and could mediate cytokine-i信号转导和转录激活因子7抗体 nduced insulin resistance and contribute to the pathogenesis of type II diabetes. SOCS6 and SOCS7 are expressed ubiquitously in murine tissues and SOCS6 knockout mice are growth retarded.
信号转导和转录激活因子7抗体 Also known as:
NAP 4; NAP 4 Fragment; NAP4; Nck Ash and phospholipase C binding protein; Nck Ash and phospholipase C gamma binding protein; Nck associated protein 4; NCKAP4; SH2 domain containing SOCS box protein; SOCS 7; SOCS4; SOCS6; Suppressor of cytokine signaling 7;SOCS7_HUMAN.
Specificity:
●
Rabbit Polyclonal IgG, affinity purified by Protein A.
●
Reacts with: Human, Mouse, Rat, Rabbit, .
●
Immunogen: KLH conjugated synthetic peptide derived from human SOCS7.
●
信号转导和转录激活因子7抗体 Predicted Molecular Weight: 63kDa.
Storage:
Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
kl303Rb51半乳糖凝集素3(GAL3)多克隆抗体Polyclonal Antibody to Galectin 3 (GAL3)
kl303Si01半乳糖凝集素3(GAL3)多克隆抗体Polyclonal Antibody to Galectin 3 (GAL3)
kl304Bo01半乳糖凝集素4(GAL4)多克隆抗体Polyclonal Antibody to Galectin 4 (GAL4)
kl304Hu01半乳糖凝集素4(GAL4)多克隆抗体Polyclonal Antibody to Galectin 4 (GAL4)
kl304Mu01半乳糖凝集素4(GAL4)多克隆抗体Polyclonal Antibody to Galectin 4 (GAL4)
kl304Po01半乳糖凝集素4(GAL4)多克隆抗体Polyclonal Antibody to Galectin 4 (GAL4)
kl304Ra01半乳糖凝集素4(GAL4)多克隆抗体Polyclonal Antibody to Galectin 4 (GAL4)
kl304Rb51半乳糖凝集素4(GAL4)多克隆抗体Polyclonal Antibody to Galectin 4 (GAL4)
kl306Bo01组织蛋白酶L(CTSL)多克隆抗体Polyclonal Antibody to Cathepsin L (CTSL)
kl306Fi01组织蛋白酶L(CTSL)多克隆抗体Polyclonal Antibody to Cathepsin L (CTSL)
kl306Hu01组织蛋白酶L(CTSL)多克隆抗体Polyclonal Antibody to Cathepsin L (CTSL)
kl306Mu01组织蛋白酶L(CTSL)多克隆抗体Polyclonal Antibody to Cathepsin L (CTSL)
kl306Po01组织蛋白酶L(CTSL)多克隆抗体Polyclonal Antibody to Cathepsin L (CTSL)
kl306Ra01组织蛋白酶L(CTSL)多克隆抗体Polyclonal Antibody to Cathepsin L (CTSL)
kl307Hu01半乳糖凝集素7(GAL7)多克隆抗体Polyclonal Antibody to Galectin 7 (GAL7)
kl307Mu01半乳糖凝集素7(GAL7)多克隆抗体Polyclonal Antibody to Galectin 7 (GAL7)
kl307Ra01半乳糖凝集素7(GAL7)多克隆抗体Polyclonal Antibody to Galectin 7 (GAL7)
kl308Bo01半乳糖凝集素8(GAL8)多克隆抗体Polyclonal Antibody to Galectin 8 (GAL8)
kl308Hu01半乳糖凝集素8(GAL8)多克隆抗体Polyclonal Antibody to Galectin 8 (GAL8)
kl308Mu01半乳糖凝集素8(GAL8)多克隆抗体Polyclonal Antibody to Galectin 8 (GAL8)
kl308Po01半乳糖凝集素8(GAL8)多克隆抗体Polyclonal Antibody to Galectin 8 (GAL8)
kl308Ra01半乳糖凝集素8(GAL8)多克隆抗体Polyclonal Antibody to Galectin 8 (GAL8)
kl309Bo01半乳糖凝集素9(GAL9)多克隆抗体Polyclonal Antibody to Galectin 9 (GAL9)
kl309Ca01半乳糖凝集素9(GAL9)多克隆抗体Polyclonal Antibody to Galectin 9 (GAL9)
kl309Hu01半乳糖凝集素9(GAL9)多克隆抗体Polyclonal Antibody to Galectin 9 (GAL9)
kl309Mu01半乳糖凝集素9(GAL9)多克隆抗体Polyclonal Antibody to Galectin 9 (GAL9)
相关产品
关注
拨打电话
留言咨询