糖皮质激素诱导肿瘤坏死因子受体抗体

Quantity size:

0.2ml

Concentration:

1mg/ml 糖皮质激素诱导肿瘤坏死因子受体抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

TNFRSF18 or GITR (glucocorticoid-induced TNF receptor family-regulated gene) is a 25 kD TNF receptor superfamily member (also known as AITR and TNFRSF18) originally identified in the mouse by comparing untreated and dexamethasone-treated murine T cell hybridoma cells. Human GITR was subsequently identified by searching an expressed sequence tag database. GITR is expressed on activated lymphocytes and is upregulated by T cell receptor engagement. The cytoplasmic domain of GITR is homologous to CD40, 4-1BB and CD27 糖皮质激素诱导肿瘤坏死因子受体抗体and has been shown to interact with TRAF 1-3, but not TRAF 5 or 6. GITR signaling has been shown to regulate T cell proliferation and TCR-mediated apoptosis, and to break immunological self-tolerance. GITR appears to be highly expressed on CD4+CD25+ T regulatory cells and has been shown to induce NF-kB activation through TRAF2/NIK signaling. GITR has been proposed to be involved in the development of regulatory T cells and to regulate the activity of Th1 subsets. GITR binds GITRL, a TNF superfamily ligand expressed on endothelial cells, dendritic cells, macrophages, and B cells.

糖皮质激素诱导肿瘤坏死因子受体抗体Also known as:

Activation inducible TNFR family receptor; Activation-inducible TNFR family receptor; CD357; AITR; GITR; GITR D; GITR-D; GITRD; Glucocorticoid induced TNFR related protein; glucocorticoid-induced tnf receptor ligand; Glucocorticoid induced TNFR related protein; TNF receptor superfamily activation inducible protein; Glucocorticoid-induced TNFR-related protein; TNF receptor superfamily activation inducible protein; TNR18_HUMAN; TNFRSF 18; TNFRSF18; Tumor necrosis factor receptor superfamily member 18;糖皮质激素诱导肿瘤坏死因子受体抗体 Tumor necrosis factor receptor superfamily member 18 precursor.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, .

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Immunogen: KLH conjugated synthetic peptide derived from human TNFRSF18.

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糖皮质激素诱导肿瘤坏死因子受体抗体Predicted Molecular Weight: 24kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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