促甲状腺素受体抗体

Quantity size:

0.2ml

Concentration:

1mg/ml 促甲状腺素受体抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

The glycoprotein hormone receptor family consists of the luteinizing hormone receptor, the follicle-stimulating hormone receptor, and the thyroid stimulating hormone(TSH) receptor. TSH, which is released from the pituitary gland, binds to the TSH receptor on thyroid cells to control size and function of the thyroid gland (De Felice et al. 2004). The TSH receptor signals through Gs to elevate intracellular cAMP in the thyroid gland, which regulates iodide uptake, and transcription of thyroglobulin (Tg),促甲状腺素受体抗体 thyroid peroxidase (TPO), and sodium-iodide symporter. The TSH receptor also signals Gq and phospholipase C to regulat iodide efflux, H2O2 production, and thyroglobulin iodination. Autoimmunity to the TSH receptor causes hyperthyroidism (Graves disease) or hypothyroidism (Hashimoto thyroiditis) when the autoantibodies function as agonists or antagonists, respectively, at the TSH receptor (Rapoport and McLachlan, 2001; Davies et al., 2002). Millipore’s cloned human TSH receptor-expressing cell line is made in the Chem-10 促甲状腺素受体抗体host, which supports high levels of recombinant TSH receptor expression on the cell surface and contains high levels of the promiscuous G protein to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for antagonists of interactions between TSH and its ligands.

Also known as:

hTSHR I; hTSHRI; LGR 3; LGR3; MGC75129; Thyroid adenoma hyperfunctioning; Thyroid carcinoma with thyrotoxicosis;促甲状腺素受体抗体 Thyroid Stimulating Hormone Receptor; Thyrotropin Receptor; Thyrotropin receptor I; TSH R; TSHR; Thyroid stimulating hormone receptor; TSHR_HUMAN.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, Rat, Chicken, Pig, Cow, Horse, Rabbit, Guinea Pig, .

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Immunogen: KLH conjugated synthetic peptide derived from human TSHR.

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促甲状腺素受体抗体Predicted Molecular Weight: 86kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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kl013Ga01骨成型蛋白2(BMP2)多克隆抗体Polyclonal Antibody to Bone Morphogenetic Protein 2 (BMP2)

kl013Hu01骨成型蛋白2(BMP2)多克隆抗体Polyclonal Antibody to Bone Morphogenetic Protein 2 (BMP2)

kl013Mu01骨成型蛋白2(BMP2)多克隆抗体Polyclonal Antibody to Bone Morphogenetic Protein 2 (BMP2)

kl013Po01骨成型蛋白2(BMP2)多克隆抗体Polyclonal Antibody to Bone Morphogenetic Protein 2 (BMP2)

kl013Ra01骨成型蛋白2(BMP2)多克隆抗体Polyclonal Antibody to Bone Morphogenetic Protein 2 (BMP2)

kl013Rb52骨成型蛋白2(BMP2)多克隆抗体Polyclonal Antibody to Bone Morphogenetic Protein 2 (BMP2)

kl014Bo01骨成型蛋白4(BMP4)多克隆抗体Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4)

kl014Ca01骨成型蛋白4(BMP4)多克隆抗体Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4)

kl014Cp01骨成型蛋白4(BMP4)多克隆抗体Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4)

kl014Ga01骨成型蛋白4(BMP4)多克隆抗体Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4)

kl014Po01骨成型蛋白4(BMP4)多克隆抗体Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4)

kl014Rb53骨成型蛋白4(BMP4)多克隆抗体Polyclonal Antibody to Bone Morphogenetic Protein 4 (BMP4)

kl015Hu01骨成型蛋白受体1A(BMPR1A)多克隆抗体Polyclonal Antibody to Bone Morphogenetic Protein Receptor 1A (BMPR1A)

kl015Mu01骨成型蛋白受体1A(BMPR1A)多克隆抗体Polyclonal Antibody to Bone Morphogenetic Protein Receptor 1A (BMPR1A)

kl015Ra01骨成型蛋白受体1A(BMPR1A)多克隆抗体Polyclonal Antibody to Bone Morphogenetic Protein Receptor 1A (BMPR1A)

kl017Bo01上皮性钙黏附蛋白(CDHE)多克隆抗体Polyclonal Antibody to Cadherin, Epithelial (CDHE)

kl017Ga01上皮性钙黏附蛋白(CDHE)多克隆抗体Polyclonal Antibody to Cadherin, Epithelial (CDHE)

kl017Hu01上皮性钙黏附蛋白(CDHE)多克隆抗体Polyclonal Antibody to Cadherin, Epithelial (CDHE)

kl017Mu01上皮性钙黏附蛋白(CDHE)多克隆抗体Polyclonal Antibody to Cadherin, Epithelial (CDHE)

kl017Po01上皮性钙黏附蛋白(CDHE)多克隆抗体Polyclonal Antibody to Cadherin, Epithelial (CDHE)

kl017Ra01上皮性钙黏附蛋白(CDHE)多克隆抗体Polyclonal Antibody to Cadherin, Epithelial (CDHE)