转录因子相关蛋白TRRAP抗体

Quantity size:

0.2ml

Concentration:

1mg/ml 转录因子相关蛋白TRRAP抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

The transcription factors c-Myc and E2F are involved in regulating cell cycle progression. Overexpression of c-Myc in certain cell types induces noncycling cells to enter the cell cycle via a mechanism involving E2F-1 (1). E2F-1 is thought to regulate c-Myc expression via 转录因子相关蛋白TRRAP抗体interactions with the retinoblastoma protein (2). TRRAP (for transformation/transcription domain-associated protein) interacts specifically with both c-Myc and E2F-1. Expression of trans-activated mutant TRRAP inhibits the oncogenic transformation of both c-Myc and E2F-1, suggesting that TRRAP is required for these oncogenic transcription factor pathways (3). TRRAP shares homology with the ATM/PI 3-kinase family, and it is highly conserved in evolution (4,5).

转录因子相关蛋白TRRAP抗体Also known as:

350/400 kDa PCAF associated factor; FLJ10671; PAF 350/400; PAF 400; PAF350/400; PAF400; STAF 40; STAF40; TR AP; Tra 1; Tra1; Tra1 homolog; Transactivation / transformation domain associated protein; Transactivation/transformation domain associated protein; Transformation/transcription domain associated protein; TRAP; TRRAP_HUMAN.

Specificity:

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Rabbit Polyclonal IgG,转录因子相关蛋白TRRAP抗体 affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Sheep, Xenopus laevis.

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Immunogen: KLH conjugated synthetic peptide derived from human TRRAP.

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转录因子相关蛋白TRRAP抗体Predicted Molecular Weight: 438kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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