磷酸化转铁蛋白受体抗体

Quantity size:

0.1ml

Concentration:

1mg/ml 磷酸化转铁蛋白受体抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Cellular uptake of iron occurs via receptor mediated endocytosis of ligand occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor.磷酸化转铁蛋白受体抗体 Transferrin receptor is necessary for development of erythrocytes and the nervous system. Useful in studies of dividing haematopoietic and tumour cell populations, and metabolic activity. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C terminal binding site. The antigen is present on most dividing cells, including normally cycling in vivo hematopoietic progenitor cells, mitogenically stimulated cells in vitro, some primary tumor cells and most proliferating cells in vitro.

磷酸化转铁蛋白受体抗体Also known as:

Transferrin Receptor (phospho S24); p-Transferrin Receptor (phospho S24); CD 71; CD71; CD71 antigen; OTTHUMP00000208523; OTTHUMP00000208524; OTTHUMP00000208525; p90; sTfR; T9; TFR 1; TFR; TFR1; TFR1_HUMAN; TFRC; TR; Transferrin receptor (p90 CD71); Transferrin Receptor Protein 1; Transferrin receptor protein 1, serum form; TRFR.

Specificity:

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Rabbit Polyclonal IgG, 磷酸化转铁蛋白受体抗体affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Dog, Pig, Cow, Horse, .

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Immunogen: KLH conjugated synthesised phosphopeptide derived from human Transferrin Receptor around the phosphorylation site of Ser24.

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Predicted Molecular Weight: 85kDa.

磷酸化转铁蛋白受体抗体Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user

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