磷酸化酪氨酸激酶A抗体

Quantity size:

0.1ml

Concentration:

1mg/ml 磷酸化酪氨酸激酶A抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

The Trk family of nerve growth factor receptors includes Trk A(also referfed to as Trk A gp140),Trk B and Trk C. The prototype member of this gene family, Trk A, encodes a 140 kDa cell surface receptor , gp140, the expression of which is restricted in vivo to neurons of the sensory spinal and cranial gangliaof neurocrest origin. Nerve growth factor (NGF) stimulates tyrosine phosphorylation of Trk gp 140 in neural cell lines and in embryonic磷酸化酪氨酸激酶A抗体 dorsal root ganglia. By comparison, BDNF and to a lesser extent, NT-3, but not NGF, can induce tyrosine phophorylayion of Trk B gp 145. The third member of the Trk receptor family, Trk C incodes a 140 kDa protein, Trk C gp140, that is preferentially expressed in brain tissue and primarily functions as a receptor for NT-3.An additional component of the Trk receptor complex, NGFR p175, binds to neurotrophic factors with low affinity but is required for efficient signaling. NGFR p175 accelerates Trk activation and may recruit downstream dffector molecules to the ligand-bound receptor complex.

磷酸化酪氨酸激酶A抗体Also known as:

TrkA (phospho Y490); TrkA (phospho Tyr790); p-TrkA (phospho Y490); NTRK1(phospho Y490); CIPA; High affinity nerve growth factor receptor precursor; MTC; Neurotrophic tyrosine kinase receptor type 1; Ntrk 1; Ntrk1; Oncogene TRK; p140 TrkA; TRK 1; Trk A; TRK; TRK1; TRK1 transforming tyrosine kinase protein; Tyrosine Receptor Kinase A.

Specificity:

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Rabbit Polyclonal IgG,磷酸化酪氨酸激酶A抗体 affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Chicken, Horse, Sheep, .

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Immunogen: KLH conjugated synthesised phosphopeptide derived from human TrkA isoform 1(790aa) around the phosphorylation site of Tyr490.

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磷酸化酪氨酸激酶A抗体Predicted Molecular Weight: 17kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  Flow-Cyt=1:50-500  ICC=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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