TH糖蛋白抗体

Quantity size:

0.2ml

Concentration:

1mg/ml TH糖蛋白抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

May play a role in regulating the circulating activity of cytokines as it binds to IL-1, IL-2 and TNF with high affinity.
Tissue specificity:Synthesized by kidney. Most abundant protein in normal human urine.
Involvement in disease:Defects in UMOD are the cause of familial juvenile hyperuricemic nephropathy type 1 (HNFJ1) . HNFJ1 is a renal disease characterized by juvenil onset of hyperuricemia, polyuria, progressive renal failure, and gout. The disease is associated with interstitial pathological changes resulting in fibrosis.
Defects in UMOD are the cause of TH糖蛋白抗体 medullary cystic kidney disease type 2 (MCKD2) [MIM:603860]. MCKD2 is a form of tubulointerstitial nephropathy characterized by formation of renal cysts at the corticomedullary junction. It is characterized by adult onset of impaired renal function and salt wasting resulting in end-stage renal failure by the sixth decade. his gene encodes uromodulin, the most abundant protein innormal urine. Its excretion in urine follows proteolytic cleavageof the ectodomain of its glycosyl phosphatidylinosital-anchoredcounterpart that is situated on the luminal cell surface of theloop of Henle. Uromodulin may act as a constitutive inhibitor ofcalcium crystallizationTH糖蛋白抗体  in renal fluids. Excretion of uromodulin inurine may provide defense against urinary tract infections causedby uropathogenic bacteria. Defects in this gene are associated withthe autosomal dominant renal disorders medullary cystic kidneydisease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy(FJHN). These disorders are characterized by juvenile onset ofhyperuricemia, gout, and progressive renal failure. While severaltranscript variants may exist for this gene, the full-lengthnatures of only two have been described to date. These tworepresent the major variants of this gene and encode the sameisoform.

TH糖蛋白抗体 Also known as:

ADMCKD2; FJHN; HNFJ; HNFJ1; MCKD2; medullary cystic kidney disease 2 (autosomal dominant); Tamm Horsfall glycoprotein; Tamm Horsfall urinary glycoprotein; Tamm-Horsfall urinary glycoprotein; THGP; THP; Umod; UROM_HUMAN; Uromodulin.

Specificity:

●

Rabbit Polyclonal IgG, affinity purified by Protein A.

●

Reacts with: Human, Mouse, Rat, Pig, Cow, Horse, Sheep, .

●

Immunogen: KLH conjugated synthetic peptide derived from human Uromodulin (405-455aa).

●

TH糖蛋白抗体 Predicted Molecular Weight: 61/64kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

kl243Hu01拓扑异构酶Ⅰ(TOP1)多克隆抗体Polyclonal Antibody to Topoisomerase I (TOP1)

kl246Mu01磷酸肌醇依赖性蛋白激酶1(PDPK1)多克隆抗体Polyclonal Antibody to Phosphoinositide Dependent Protein Kinase 1 (PDPK1)

kl257Hu0162kDa核孔蛋白(NUP62)多克隆抗体Polyclonal Antibody to Nucleoporin 62kDa (NUP62)

kl260Hu01融合蛋白(FUS)多克隆抗体Polyclonal Antibody to Fusion (FUS)

kl260Mu01融合蛋白(FUS)多克隆抗体Polyclonal Antibody to Fusion (FUS)

kl262Hu01紧密连接蛋白1(TJP1)多克隆抗体Polyclonal Antibody to Tight Junction Protein 1 (TJP1)

kl268Hu0111-β-羟基类固醇脱氢酶1(HSD11β1)多克隆抗体Polyclonal Antibody to 11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1)

kl268Ra0111-β-羟基类固醇脱氢酶1(HSD11β1)多克隆抗体Polyclonal Antibody to 11-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD11b1)

kl270Hu017-脱氢胆固醇还原酶(DHCR7)多克隆抗体Polyclonal Antibody to 7-Dehydrocholesterol Reductase (DHCR7)

kl276Hu01氨基酰化酶1(ACY1)多克隆抗体Polyclonal Antibody to Aminoacylase 1 (ACY1)

kl281Hu01腺苷激酶(ADK)多克隆抗体Polyclonal Antibody to Adenosine Kinase (ADK)

kl284Hu01α白蛋白(AFM)多克隆抗体Polyclonal Antibody to Afamin (AFM)

kl284Mu01α白蛋白(AFM)多克隆抗体Polyclonal Antibody to Afamin (AFM)

kl285Hu01前梯度蛋白2(AGR2)多克隆抗体Polyclonal Antibody to Anterior Gradient Protein 2 (AGR2)

kl288Hu01同种异体移植炎症因子1(AIF1)多克隆抗体Polyclonal Antibody to Allograft Inflammatory Factor 1 (AIF1)

kl288Mu01同种异体移植炎症因子1(AIF1)多克隆抗体Polyclonal Antibody to Allograft Inflammatory Factor 1 (AIF1)

kl292Hu01氨乙酰丙酸δ脱水酶(ALAD)多克隆抗体Polyclonal Antibody to Aminolevulinate Delta Dehydratase (ALAD)

kl295Hu01无羊膜蛋白(AMN)多克隆抗体Polyclonal Antibody to Amnionless (AMN)

kl298Mu01含铜胺氧化酶3(AOC3)多克隆抗体Polyclonal Antibody to Amine Oxidase, Copper Containing 3 (AOC3)

kl299Hu01载脂蛋白M(APOM)多克隆抗体Polyclonal Antibody to Apolipoprotein M (APOM)

kl300Hu01中脑星形胶质细胞来源神经营养因子(MANF)多克隆抗体Polyclonal Antibody to Mesencephalic Astrocyte Derived Neurotrophic Factor (MANF)

kl302Hu01N-酰基鞘氨醇酰胺水解酶1(ASAH1)多克隆抗体Polyclonal Antibody to N-Acylsphingosine Amidohydrolase 1 (ASAH1)

kl303Mu01转录激活因子3(ATF3)多克隆抗体Polyclonal Antibody to Activating Transcription Factor 3 (ATF3)

kl304Hu01吸引素(ATRN)多克隆抗体Polyclonal Antibody to Attractin (ATRN)