供货周期: | 现货 |
品牌: | 康朗生物 |
规格: | 0.1ml/0.2ml |
货号: | KL8380R |
CAS号: |
Quantity size:
0.2ml
Concentration:
1mg/ml 泛素结合酶E2 230K抗体 Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Background:
UBE20, also known as E2-230K, is a 1,292 amino acid member of the uniquitin-conjugating enzyme family that is involved in protein modification. Expressed predominately in heart and skeletal muscle, UBE2O functions to catalyze the ATP-dependent covalent attachment of ubiquitin to select proteins, thereby targeting the ubiquitinated proteins for泛素结合酶E2 230K抗体 proteasomal degradation. The gene encoding UBE2O maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.
泛素结合酶E2 230K抗体 Also known as:
E2 230K; ubiquitin-conjugating enzyme E2O; EC=6.3.2.19; FLJ12878; KIAA1734; Likely Ortholog of Mouse Ubiquitin Conjugating Enzyme; RP23 193A16.5; UBE2O; UBE2O_HUMAN; Ubiquitin carrier protein O; Ubiquitin conjugating enzyme E2 O; ubiquitin conjugating enzyme E2O.
Specificity:
●
Rabbit Polyclonal IgG, 泛素结合酶E2 230K抗体 affinity purified by Protein A.
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Reacts with: Mouse, Rat, Chicken, Pig, Horse, .
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Immunogen: KLH conjugated synthetic peptide derived from human UBE2O/E2 230K.
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Predicted Molecular Weight: 141kDa.
泛素结合酶E2 230K抗体 Storage:
Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).
Application:
ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200
Not yet tested in other applications.
Optimal working dilutions must be determined by the end user.
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