Wnt信号受体蛋白/Frizzled homolog 1抗体

Quantity size:

0.2ml

Concentration:

1mg/ml Wnt信号受体蛋白/Frizzled homolog 1抗体  Buffer = 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Background:

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK3 kinase, nuclear accumulation of beta catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members,Wnt信号受体蛋白/Frizzled homolog 1抗体 but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt mediated inactivation of GSK3 kinase. Both pathways seem to involve interactions with G proteins. May be involved in transduction and Wnt信号受体蛋白/Frizzled homolog 1抗体intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activated by Wnt3A, Wnt3, Wnt1 and to a lesser extent Wnt2, but not by Wnt4, Wnt5A, Wnt5B, Wnt6, Wnt7A or Wnt7B.

Wnt信号受体蛋白/Frizzled homolog 1抗体Also known as:

Frizzled 1; Frizzled-1; Frizzled homolog 1 (Drosophila); Fz1; FZD1; FzE1; Wnt receptor; FZD1_HUMAN.

Specificity:

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Rabbit Polyclonal IgG, affinity purified by Protein A.

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Reacts with: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, .

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Immunogen: KLH conjugated synthetic peptide derived from human Frizzled 1.

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Wnt信号受体蛋白/Frizzled homolog 1抗体Predicted Molecular Weight: 63/71kDa.

Storage:

Shipped at 4℃, Store at -20℃ (Avoid repeated freeze/thaw cycles).

Application:

WB=1:100-500  ELISA=1:500-1000  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500   
Not yet tested in other applications. 
Optimal working dilutions must be determined by the end user.

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