ProPac SCX和WCX蛋白质柱 SP5482_价格_上海希言科学仪器有限公司

产品详情

Strong and Weak Cation-Exchange Columns for High-Resolution Separation of Proteins and MAbs

New! The Thermo Scientific ProPac^™ SCX column line has expanded to include the next generation ProPac SCX-20 column. This column provides unequalled high resolution of protein variants.

Please also see the Thermo Scientific MAbPac^™ SCX-10 column, a strong cation-exchange column designed specifically for high-resolution, high-efficiency analysis of monoclonal antibodies (MAbs) and associated variants. This column is complimentary to the industry-leading ProPac WCX-10 column for monoclonal antibody variant analysis. The MAbPac SCX-10 offers an alternative selectivity and provides higher resolution and efficiency for variant analysis of most monoclonal antibody samples than the ProPac WCX-10 column.

ProPac SCX-10 and WCX-10 strong and weak cation-exchange columns are based on a nonporous core particle that results in high-efficiency peaks and high-resolution separations of protein variants. A hydrophilic layer prevents unwanted secondary interactions. A grafted cation-exchange surface provides pH-based selectivity control and fast mass transfer for high-efficiency separation and moderate capacity.

Characterization and quality control assessment of monoclonal antibodies and other proteins
Unequalled resolution
High-resolution separations with excellent sample recovery
Unmatched column-to-column and lot-to-lot reproducibility
Useful for characterization of related protein variants (e.g., deamidation and MAb lysine truncation variants)
Highly-efficient peaks with excellent sample recovery
Available in different dimensions and formats for flexibility in method development

The ProPac SCX-10 is a strong cation-exchange column with sulfonate functional groups, and the ProPac WCX-10 column has a carboxylate functional group. Both are based on 10 μm nonporous, polymeric beads and coated with a proprietary hydrophilic layer.

All ProPac columns are manufactured and tested under the strictest specifications, resulting in unmatched column-to-column and lot-to-lot reproducibility. These columns are available as lot-select packages containing three columns from a single lot or three columns from three different lots, to assist quality control scientists in method validation.

ProPac SCX-10 Strong Cation-Exchange Column for the High-Resolution Separation of Protein Isoforms Specifications
Maximum operating pressure	3000 psi (21 MPa)
Maximum operating temperature	60 °C Recommended operating temperature:<40 °C
Typical operating conditions	UV detection at 1 mL/min Recommended flow rate: 1 mL/min
Mobile phase compatibility	pH 2–12; 80% compatible with acetonitrile, acetone, methanol. Compatible with nonionic and zwitterionic detergents. Incompatible with cationic detergents.
Resin composition	10-μm-diameter core bead (55% cross-linked) grafted with a pellicular layer to which are attached the sulfonate functional groups.
Anion-exchange capacity	< 100 μg protein on-column, depending upon the protein (4 × 250 mm analytical column)
Column construction	PEEK with 10-32 threaded ferrule-style end fittings. All components are nonmetallic.

ProPac WCX-10 Weak Cation-Exchange Column for the High-Resolution Separation of Protein Isoforms Specifications
Resin composition	10-μm-diameter core bead (55% cross-linked) grafted with a pellicular layer to which are attached the carboxylate functional groups.
Anion-exchange capacity	< 100 μg protein on-column, depending upon the protein (4 × 250 mm analytical column)
Column construction	PEEK with 10-32 threaded ferrule-style end fittings. All components are nonmetallic.
Maximum operating pressure	3000 psi (21 MPa)
Maximum operating temperature	60 °C Recommended operating temperature:<40 °C
Typical operating conditions	UV detection at 1 mL/min Recommended flow rate: 1 mL/min
Mobile phase compatibility	pH 2–12; 80% compatible with acetonitrile and acetone. Compatible with nonionic and zwitterionic detergents. Incompatible with cationic detergents.

SCX Analytical Columns
ProPac SCX-20 Analytical Column (4 x 250 mm)	074628
ProPac SCX-10 Analytical Column (4 x 250 mm)	054995
ProPac SCX-10 Analytical Column (2 x 250 mm)	063456
ProPac SCX-10 Semi-Preparative Column (9 x 250 mm)	063700
ProPac SCX-10 Semi-Preparative Column (22 x 250 mm)	SP5522
ProPac SCX-10 Lot Select Column Set (4 x 250 mm) (1 Lot of Resin)	SP5727
ProPac SCX-10 Lot Select Column Set (4 x 250 mm) (3 Lots of Resin)	SP5728

SCX Guard Columns
ProPac SCX-20 Guard Column (4 x 50mm)	074643
ProPac SCX-10G Guard Column (4 x 50 mm)	079930
ProPac SCX-10G Guard Column (2 x 50 mm)	063462

WCX Analytical Columns
ProPac WCX-10HT Analytical Column (4x 50mm)	074600
ProPac WCX-10 Analytical Column (4 x 100 mm)	SP5829
ProPac WCX-10 Analytical Column (4 x 150 mm)	SP6703
ProPac WCX-10 Analytical Column (4 x 250 mm)	054993
ProPac WCX-10 Lot Select 3 Column Set (4 x 250 mm) (1 Lot of Resin)	SP5512
ProPac WCX-10 Lot Select 3 Column Set (4 x 250 mm) (3 Lots of Resin)	SP5513
ProPac WCX-10 Analytical Column (2 x 250 mm)	063472
ProPac WCX-10 Semi-Preparative Column (9 x 250 mm)	063474
ProPac WCX-10 Semi-Preparative Column (22 x 250 mm)	SP5482

WCX Guard Columns
ProPac WCX-10G Guard Column (2 x 50 mm)	063480
ProPac WCX-10G Guard Column (4 x 50 mm)	054994

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供货周期：	现货
品牌：	戴安
货号：	SP5482