| 供货周期： | 现货 |
| 品牌： | LMAI Bio |
| 规格： | 50ul/100ul/200ul |
| 货号： | LM20373R |
| CAS号： |
白细胞介素10抗体
英文名称 IL-10
中文名称 白细胞介素10抗体
别 名 Interleukin-10 precursor; Cytokine synthesis inhibitory factor; CSIF; Cytokine Synthesis Inhibitory Factor; IL 10; IL10A; Interleukin 10; Interleukin10; MGC126450; MGC126451; TGIF; IL10_HUMAN.
研究领域 细胞生物 免疫学 转录调节因子
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat,
产品应用 WB=1:500-2000 ELISA=1:500-1000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 20kDa
细胞定位 分泌型蛋白
性 状 Lyophilized or Liquid
浓 度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human IL-10:51-100/178
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 IL-10 protein is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.
白细胞介素-10(IL-10)是主要由Th2细胞所产生的一种细胞因子，活化的B细胞、单核巨噬细胞和枯否氏细胞（Kupffer's cell）等也可产生IL-10。它是以抑制Th细胞克隆细胞因子合成为特点的多效免疫调节因子。 白介素-10是维护细胞因子网络平衡的重要负调节因子。其作用机制可能是降低抗原递呈细胞MHCⅡ类抗原表达，或诱导抗原递呈细胞产生另一种细胞因子，改变细胞内信号传递途径，从而选择性抑制某些细胞因子mRNA转录，并与Th2细胞产生的IL-4、IL-5有协同作用。
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