血管假性血友病因子/血管性血友病因子抗体_价格

产品详情

血管假性血友病因子/血管性血友病因子抗体

英文名称 VWF

中文名称血管假性血友病因子/血管性血友病因子抗体

别名 Von Willebrand Factor; Coagulation factor VIII; F8VWF; Factor VIII related antigen; von Willebrand antigen 2; Von Willebrand antigen II; Von Willebrand disease; VWD; VWF; VWF_HUMAN.

研究领域心血管细胞生物免疫学

抗体来源 Rabbit

克隆类型 Polyclonal

交叉反应 Human, Mouse, Rat, Dog, Pig, Rabbit,

产品应用 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=3ug/Test ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分子量 309kDa

细胞定位细胞外基质分泌型蛋白

性状 Lyophilized or Liquid

浓度 1mg/ml

免疫原 KLH conjugated synthetic peptide derived from human VWF:1701-1800/2813

亚型 IgG

纯化方法 affinity purified by Protein A

储存液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed

产品介绍 Von Willebrand Factor (VWF) was previously known as Factor VIII related antigen. VWF is synthesized exclusively by endothelial cells and megakaryocytes, and stored in the intracellular granules or constitutively secreted into plasma. This glycoprotein functions as both an antihemophilic factor carrier and a platelet vessel wall mediator in the blood coagulation system. Important in the maintenance of homeostasis, it participates in platelet vessel wall interactions by forming a noncovalent complex with coagulation factor VIII at the site of vascular injury. The Von Willebrand factor has functional binding domains to platelet glycoprotein Ib, glycoprotein IIb/IIIa, collagen and heparin. Mutations in this gene or deficiencies in this protein result in Von Willebrand's disease. VWD is characterized by frequent bleeding (gingival, minor skin quantitative lacerations, menorrhagia, etc.).

血管性血友病因子(vWF)是血管内皮细胞和骨髓巨核细胞合成的一种糖蛋白，在1期和2期止血中都起着重要作用，如缺乏将导致患者出现血管性血友病(vWD)。vWF可被ADAMTS13裂解以失去活性，血小板反应蛋白/凝血酶敏感蛋白-1(Thrombospondin,TSP-1))可参与了这个调节过程。vWF水平受多种遗传和环境因素影响，其中ABO血型影响较大。vWF主要通过A1和A3区与血小板GP 1b和胶原结合，在止血和血栓形成过程中起重要作用，并与心、脑血管疾病及血管新生密切相关，因此研究vWF的生物学特性和功能具有重要的意义。

血管假性血友病因子/血管性血友病因子抗体信息由上海联迈生物工程有限公司为您提供，如您想了解更多关于血管假性血友病因子/血管性血友病因子抗体报价、型号、参数等信息，欢迎来电或留言咨询。除供应血管假性血友病因子/血管性血友病因子抗体外，上海联迈生物工程有限公司还可为您提供骨桥蛋白/分泌型磷蛋白1抗体、早老素蛋白-1抗体等产品，公司有专业的客户服务团队，是您值得信赖的合作伙伴。

供货周期：	现货
品牌：	LMAI Bio
规格：	50ul/100ul/200ul
货号：	LM20428R
CAS号：