生长因子受体结合蛋白10抗体_价格_上海联迈生物工程有限公司

产品详情

生长因子受体结合蛋白10抗体

英文名称 GRB10

中文名称生长因子受体结合蛋白10抗体

别名 GRB IR; grb-10; GRB10 adaptor protein; GRBIR; Growth factor receptor bound protein 10; Insulin receptor binding protein; Insulin receptor binding protein GRB IR; IRBP; MEG1; RSS.

研究领域细胞生物神经生物学信号转导细胞凋亡生长因子和激素激酶和磷酸酶细胞膜受体糖尿病内分泌病

抗体来源 Rabbit

克隆类型 Polyclonal

交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,

产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分子量 65kDa

细胞定位细胞浆

性状 Lyophilized or Liquid

浓度 1mg/ml

免疫原 KLH conjugated synthetic peptide derived from human GRB10:501-594/594

亚型 IgG

纯化方法 affinity purified by Protein A

储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed

产品介绍 Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2.

生长因子受体结合蛋白10与胰岛素抵抗、2型糖尿病以及个体生长发育有关。

生长因子受体结合蛋白10抗体信息由上海联迈生物工程有限公司为您提供，如您想了解更多关于生长因子受体结合蛋白10抗体报价、型号、参数等信息，欢迎来电或留言咨询。除供应生长因子受体结合蛋白10抗体外，上海联迈生物工程有限公司还可为您提供核突触蛋白-α抗体（N端）、巢蛋白/神经上皮干细胞蛋白抗体等产品，公司有专业的客户服务团队，是您值得信赖的合作伙伴。

供货周期：	现货
品牌：	LMAI Bio
规格：	50ul/100ul/200ul
货号：	LM2769R
CAS号：