抑癌蛋白EZH2抗体_价格_上海联迈生物工程有限公司

产品详情

抑癌蛋白EZH2抗体

英文名称 KMT6

中文名称抑癌蛋白EZH2抗体

别名 Enhancer of zeste homolog 2; Enx1h; MGC9169; Enhancer of zeste 2; ENX-1; ENX 1; ENX1; EZH1; EZH2; EZH 2; EZH2_HUMAN; Histone-lysine N-methyltransferase EZH2; KMT6A; Lysine N-methyltransferase 6; Enhancer of zeste homolog 2 (Drosophila); Enhancer of zeste, Drosophila, homolog 2; KMT 6;KMT6A; WVS2.

研究领域肿瘤细胞生物免疫学神经生物学生长因子和激素转录调节因子激酶和磷酸酶

抗体来源 Rabbit

克隆类型 Polyclonal

交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,

产品应用 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1ug/Test ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分子量 82kDa

细胞定位细胞核

性状 Lyophilized or Liquid

浓度 1mg/ml

免疫原 KLH conjugated synthetic peptide derived from human KMT6/EZH2:255-350/746

亚型 IgG

纯化方法 affinity purified by Protein A

储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed

产品介绍 This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Feb 2011].

EZH2（enhancer of zeste homolog 2）是新识别的一种人类基因，是果蝇zeste基因增强子的人类同源基因，Polycomb group基因家族的重要成员之一。
EZH2在多种肿瘤中高表达，具有促进细胞增殖，肿瘤细胞的扩散的恶性表型，EZH2在肿瘤中的作用成为研究热门。EZHZ在前列腺癌、乳腺癌、膀胧癌、肝细胞癌、大肠癌、胃癌中高表达;局限性前列腺癌、乳腺癌、膀胧癌高表达EZH2，则临床预后较差。因此EZH2可作为肿瘤标志物监测肿瘤的演变。随着PcG蛋白和TrxG蛋白复合物研究的深入，对细胞记忆机制的认识不断提高，而扰乱细胞的转录记忆系统可导致个体发育缺陷，使正常细胞丢失自身特性而癌变。
EZH2通过基因沉默机制改变细胞的记忆系统并调控转录，促进前肿瘤恶性形成。EZH2在肿瘤发生发展中的作用仍远未阐明,特别是EZH2的下游基因仍不清楚,EZH2在肿瘤发生与发展的机制有待进一步研究。

抑癌蛋白EZH2抗体信息由上海联迈生物工程有限公司为您提供，如您想了解更多关于抑癌蛋白EZH2抗体报价、型号、参数等信息，欢迎来电或留言咨询。除供应抑癌蛋白EZH2抗体外，上海联迈生物工程有限公司还可为您提供GALNTL6蛋白抗体、GalNAc-TL5蛋白抗体等产品，公司有专业的客户服务团队，是您值得信赖的合作伙伴。

供货周期：	现货
品牌：	LMAI Bio
规格：	50ul/100ul/200ul
货号：	LM3521R
CAS号：