纺锤体检查点蛋白抗体_价格_上海联迈生物工程有限公司

产品详情

纺锤体检查点蛋白抗体

英文名称 Bub1

中文名称纺锤体检查点蛋白抗体

别名 Bub1; BUB1 budding uninhibited by benzimidazoles 1 homolog; BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast); BUB1_HUMAN; BUB1A; BUB1L; Budding uninhibited by benzimidazoles 1 (yeast homolog); Budding uninhibited by benzimidazoles 1 homolog; hBUB1; Mitotic checkpoint serine/threonine protein kinase BUB1; Mitotic checkpoint serine/threonine-protein kinase BUB1; Mitotic spindle checkpoint kinase; Putative serine/threonine protein kinase.

研究领域肿瘤细胞生物免疫学细胞周期蛋白

抗体来源 Rabbit

克隆类型 Polyclonal

交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Rabbit,

产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分子量 122kDa

细胞定位细胞核

性状 Lyophilized or Liquid

浓度 1mg/ml

免疫原 KLH conjugated synthetic peptide derived from human Bub1:951-1085/1085

亚型 IgG

纯化方法 affinity purified by Protein A

储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed

产品介绍 Bub1 was initially identified as the mammalian homolog to the yeast protein through a cDNA screen. Bub1 encodes a kinase involved in the formation of the spindle checkpoint, an important mechanism that ensures high fidelity mitotic chromosome segregation. It is thought to be required for assembly of a functional inner centromere, sister chromatid cohesion via targeting of the Shugoshim protein and metaphase congression. Bub1 functions by phosphorylating cdc20, a member of the mitotic checkpoint complex and activating the spindle checkpoint. A related protein kinase Bub3 interacts with Bub1 and targets it to kinetochores prior to chromosome alignment. Mutations in bub1 have been associated with aneuploidy and several forms of cancer.

纺锤体检查点（spindle checkpoint)是细胞周期中的一个重要检查点，由Mad2、Bub1等染色体动粒(kinetochore)蛋白构成，像“传感器”一样能感知微管与动粒结合情况和张力。纺锤体检查点阻滞细胞进入分裂后期直到所有染色体着丝点正确与微管联接,确保染色体均等分配,维持基因组稳定性。

纺锤体检查点蛋白抗体信息由上海联迈生物工程有限公司为您提供，如您想了解更多关于纺锤体检查点蛋白抗体报价、型号、参数等信息，欢迎来电或留言咨询。除供应纺锤体检查点蛋白抗体外，上海联迈生物工程有限公司还可为您提供TAPA1蛋白；抗增生抗体靶分子1(TAPA1)重组蛋白、LYAR蛋白；Ly1抗体反应同源物(LYAR)重组蛋白等产品，公司有专业的客户服务团队，是您值得信赖的合作伙伴。

供货周期：	现货
品牌：	LMAI Bio
规格：	50ul/100ul/200ul
货号：	LM4294R
CAS号：