磷酸化3磷酸肌醇依赖性蛋白激酶1抗体_价格

产品详情

磷酸化3磷酸肌醇依赖性蛋白激酶1抗体

英文名称 Phospho-PDPK1 (Ser393)

中文名称磷酸化3磷酸肌醇依赖性蛋白激酶1抗体

别名 PDPK1(phospho Ser393); PDPK1(phospho S393); 3 phosphoinositide dependent protein kinase 1; hPDK 1; hPDK1; MGC20087 MGC35290; PDK 1; PDPK 1; PDPK1; PkB kinase; PkB kinase like gene 1; PkB like 1; PkB like; PRO0461; PDPK1_HUMAN.

产品类型磷酸化抗体

研究领域免疫学神经生物学信号转导细胞凋亡转录调节因子激酶和磷酸酶

抗体来源 Rabbit

克隆类型 Polyclonal

交叉反应 Human, Mouse, Rat,

产品应用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

分子量 61kDa

细胞定位细胞浆细胞膜

性状 Lyophilized or Liquid

浓度 1mg/ml

免疫原 KLH conjugated Synthesised phosphopeptide derived from human PDPK1 around the phosphorylation site of Ser393:SS(p-S)SH

亚型 IgG

纯化方法 affinity purified by Protein A

储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMed PubMed

产品介绍 PDK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase and the stimulation of glycogen synthesis. Because of the role that PDK plays in insulin-induced glycogen synthesis and PKC activation it is a potentially important target for metabolic drug research. There are three named isoforms.

PDK1是蛋白激酶B(PKB)的上游激酶,通过与3,4,5三磷酸磷脂酰肌醇作用激活相邻的PKB分子.PDK1能够激活包含PKB在内的一系列的AGC激酶家族成员.从而调节细胞代谢,生长,扩散,生存,抗凋亡等诸多生理过程.

磷酸化3磷酸肌醇依赖性蛋白激酶1抗体信息由上海联迈生物工程有限公司为您提供，如您想了解更多关于磷酸化3磷酸肌醇依赖性蛋白激酶1抗体报价、型号、参数等信息，欢迎来电或留言咨询。除供应磷酸化3磷酸肌醇依赖性蛋白激酶1抗体外，上海联迈生物工程有限公司还可为您提供转录因子同源蛋白NKX2.4抗体、线粒体脱偶连蛋白2抗体等产品，公司有专业的客户服务团队，是您值得信赖的合作伙伴。

供货周期：	现货
品牌：	LMAI Bio
规格：	50ul/100ul/200ul
货号：	LM5537R
CAS号：