供货周期: | 现货 |
品牌: | LMAI Bio |
型号: | 50ul/100ul/200ul |
货号: | LM33358M |
转甲状腺素蛋白/前白蛋白单克隆抗体
英文名称 TTR/Prealbumin
中文名称 转甲状腺素蛋白/前白蛋白单克隆抗体
别 名 Transthyretin; Amyloid polyneuropathy; Amyloidosis I; ATTR; Dysprealbuminemic euthyroidal hyperthyroxinemia; Dystransthyretinemic hyperthyroxinemia; HsT2651; PALB; Prealbumin amyloidosis type I; Senile systemic amyloidosis; TBPA; Transthyretin; TTR; TTR protein; prealbumin; TTHY_HUMAN.
研究领域 生长因子和激素 转运蛋白
抗体来源 Mouse
克隆类型 Monoclonal
克 隆 号 3E5
交叉反应 Human,
产品应用 IHC-P=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 14kDa
细胞定位 细胞浆 分泌型蛋白
性 状 Lyophilized or Liquid
浓 度 1mg/ml
免 疫 原 Recombinant human TTR Protein:
亚 型 IgG
纯化方法 affinity purified by Protein G
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc. [provided by RefSeq]
转甲状腺素(transthyretin,TTR)蛋白由127个氨基酸组成,在生理条件下4个TTR蛋白单体分子结合一个T4单体分子形成聚合体,存在于血液中参与甲状腺素的转运。TTR蛋白基因发生遗传性突变以及在其他因素作用下TTR蛋白聚合体不稳定,容易分离形成单体。立体结构发生变化的TTR单体,进一步重合形成蛋白纤维沉积于全身组织、脏器的细胞间质,引起末梢神经、自主神经感觉障碍以及全身症状为特征的综合临床症状,称为家族性多发性神经性损害(familial amyloidotic polyneuropathy,FAP)。
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