供货周期: | 现货 |
品牌: | 博尔森 |
规格: | 10mg |
货号: | BES250381D |
CAS号: | 30827-99-7 |
AEBSF(丝氨酸蛋白酶抑制剂)
AEBSF hydrochloride
产品规格: 10mg 100mg 1ml (10mM/DMSO)
CAS: 30827-99-7
保存条件: Store at -20℃ for 3 year(Powder); In DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
产品介绍:
基本信息:
CAS:30827-99-7
分子式:C8H10FNO2S·HCl
分子量:239.69
MDL:MFCD00132962
级别:>97% by HPLC
溶解性:溶于水。H2O:可溶性50mg/mL(如果在pH值低于7的条件下冷藏,则可稳定长达6个月。如果要求pH值大于7,应在使用前进行pH值调整。)
性状:白色粉末
敏感性:易吸潮
作用靶点:Thrombin; Influenza Virus;
作用通路:Metabolic Enzyme/Protease; Anti-infection;
用途:蛋白酶抑制剂,是一种水溶性的乳糜蛋白酶、激肽释放酶、纤溶酶、凝血酶、胰蛋白酶和相关溶栓酶的特异性不可逆抑制剂。PMSF和DFP的无毒替代品。AEBSF 在PH7的水溶液中4℃可保持稳定1-2个月,但在低PH条件下更稳定。推荐使用浓度为:0.1-1.0 mM。AEBSF 已用于细胞培养,使用浓度可达 0.25mM。
体外研究:
AEBSF inhibits the constitutive production of Aβ by directly inhibiting β-secretase in five different human cell lines, both neural and nonneural. AEBSF, as a serine protease inhibitor, inhibits the lysis of leukemic cells by human macrophages without inhibiting macrophage secretion of TNF-α and IL-1β. AEBSF also disturbs the growth of blastocysts on endometrial cells and inhibit the adhesion of HeLa cells on HUVECs by altering the protein secretion pattern.
体内研究:
AEBSF (76.8 mg/kg daily i.p.) results in prolongation of the survival of mice that have been given a lethal T. gondii infection. AEBSF also reduces airway response and underlying inflammation in cockroach allergen-induced murine model.
特别提示:本公司的所有产品仅可用于科研实验,严禁用于临床医疗及其他非科研用途!
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