供货周期: | 现货 |
品牌: | 博尔森 |
规格: | 10ug |
货号: | BES210064D |
CAS号: | 101043-37-2 |
微囊藻毒素LR (PP1 and PP2A Inhibitor)
Microcystin-LR
产品规格: 10ug
CAS: 101043-37-2
保存条件: Store at -20℃ stable for at least 12 months.
产品介绍:
基本信息:
CAS:101043-37-2
分子式:C49H74N10O12
分子量:995.17
纯度:≥95%
外观/性状:固体薄膜
溶解性:溶于甲醇,DMSO
敏感性:易吸潮
产品简介:
从淡水蓝藻铜绿微囊藻中分离出的环七肽毒素。蛋白磷酸酶1(pp1)和蛋白磷酸酶2a(pp2a)的有效抑制剂。不像秋葵酸,微囊藻毒素lr对PP1(IC50=1.7 nM)和PP2A(IC50=40 PM)均有效。以两步反应机制与磷酸酶反应,包括催化亚单位的快速结合和失活,以及较慢的共价相互作用。对蛋白激酶无影响,有助于降低蛋白激酶检测中污染磷酸酶活性的影响。微囊藻毒素lr,铜绿微囊藻溶于DMSO中也可用。
产品用途:
微囊藻毒素-lr,铜绿微囊藻是一种有效的蛋白磷酸酶1(pp1)和蛋白磷酸酶2a(pp2a)抑制剂。primary target IC50:1.7 nM and 40 pM against PP1 and PP2A, respectively
体外研究:
Microcystins are toxic molecules produced by cyanobacterial blooms due to water eutrophication. Microcystin-LR proves to be a potent inhibitor of type 1 (IC50=1.7 nM) and type 2A (IC50= 0.04 nM) protein phosphatases. Microcystin-LR inhibits the activity of both type 1 and type 2A phosphatases >10-fold more potently than okadaic acid under the same conditions. Type 2A protein phosphatases in dilute mammalian cell extracts are found to be completely inhibited by 0.5 nM microcystin-LR while type 1 protein phosphatases are only slightly affected at this concentration.
特别提示:本公司的所有产品仅可用于科研实验,严禁用于临床医疗及其他非科研用途!
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