《基于微纳界面的表面增强拉曼-微流控芯片测量技术》
We develop a series of microfluidic sensors for the early diagnostic of hepatocellular carcinoma, prostate cancer, intracranial aneurysm, cardiac diseases etc. Combined with highly sensitive optical detection technology and medical imaging technology, the devices demonstrate great potential in screening test and prognosis. Cancer biomarkers are genes, proteins, and other substances that can be detected for obtaining important information about a person’s cancer. Surface-enhanced Raman scattering (SERS) based immunoassay was proposed to detect the level of cancer biomarkers. Furthermore, circulating tumor cells escape from the primary tumor or metastasis and travel in the circulating peripheral blood, carrying important bioinformation about cancer progression and metastasis. Micro- and nanofabrication technology of SERS active substrates was studied to achieve a trace measurement result. Currently, a lot of approaches have been developed to selectively isolate high-purity CTCs from human peripheral blood samples. A novel strategy of SERS-microfluidics was employed for efficient separation and in-situ heterogeneous phenotype analysis of CTCs at single cell level.
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2023-11-23
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