多维度细胞成像
Understanding the characteristic motions of functionalized nanoparticles is crucial to understand their interactions with cells. A multi-dimensional single particle tracking technique has been developed to fully disclose the 3D translational and rotational motions of anisotropic imaging probes, as well as relevant biomolecular information, in live cells. Using plasmonic gold nanorods as probe in our recent studies, we have visualized the live endocytic and intracellular transport events of nanoparticle cargos with unprecedented details in live cells. These experiments have led to new insights on the working mechanisms of molecular motors (dynamin in clathrin mediated endocytosis and kinesin/dynein in microtubule-based intracellular transport).
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2023-12-25
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