BCEIA2023微全分析分会精彩预告：面向全社会的微型化分析技术
第二十届北京分析测试学术报告会暨展览会(BCEIA 2023) 将于2023年9月6-8日在北京 中国国际展览中心(顺义馆)召开。作为中国分析与生化技术交流与展示的“峰会”，BCEIA2023将营造浓郁的学术会展氛围，同期举办大会报告、分会报告、高峰论坛、同期会议、墙报展等精彩学术活动，面向世界科技最前沿，邀请国内外顶尖学者分享最具前瞻性的研究进展。2023年9月7-8日，BCEIA2023学术报告会——微全分析分会将在学术会议区E-306会议室举行，聚焦“面向全社会的微型化分析技术”主题，围绕微流控分析（Microfluidic Analysis）、微纳分析技术（Techniques for Micro and Nano Analysis）、样品微处理（Micro Sampling Process）、微单体分析（Single Entity Analysis）、新原理新技术新方法（New Principles, Technologies and Methods）、新仪器（New Instruments）等几个专题方向，邀请到24位国内外微全分析领域资深科学家及青年才俊带来精彩报告。最新嘉宾阵容公布如下： 召集人简介 林金明，博士，清华大学化学系教授，博士生导师。1992－2002年在日本东京都立大学学习和工作。1997年获得东京都立大学博士学位，同年留校任教。2001年入选中国科学院“百人计划”并获得国家杰出青年科学基金的资助，同年受聘中国科学院生态环境研究中心研究员，2004年入选清华大学“百人计划”，受聘清华大学化学系教授，2008年受聘教育部长江学者特聘教授，2014年入选英国皇家化学会会士。主要从事：1）微流控芯片质谱联用细胞分析方法研究；2）空气负离子制备方法及其对促进健康作用的机理研究；3）超微弱化学发光与免疫分析研究。出版《化学发光基础理论与应用》、《化学发光免疫分析》、《环境、健康与负氧离子》、《Cell Analysis on Microfluidics》及中文版《微流控芯片细胞分析》、《Microfluidics for Single-Cell Analysis》等专著七部、教科书《基础分析化学实验》和《微流控细胞分析》各一部，发表研究论文400多篇，申请发明专利51项，并且有多项专利转让企业进行产业化。目前担任中国分析测试协会常务理事，中国化学会分析化学学科副主任委员，中国药学会药物分析专业委员会副主任委员。Trends in Analytical Chemistry责任编辑，J. Pharm. Anal.副主编， Chemosensors副主编、Chinese Chemical Letters副主编，《分析试验室》副主编，以及Talanta等10多种国内外学术期刊编委。 特邀报告人 报告摘要The efficient recognition of circulating tumor cells (CTCs) with aptamer-probe has numerous benefits. We engineered a superefficient biomimetic single-CTCs recognition platform by conjugating dual-aptamer onto AuNPs to form a nanoprobe for selective binding biomarker proteins PTK7 & EpCAM on CTCs surface. CTCs are sorted on a specially designed multifunctional microfluidic configuration, and biomarkers in a single CTC are analyzed with ICP-MS by measuring 197Au isotope. This strategy ensures the manipulation and detection of a single CTC in 100 μL of human blood within 1 h.2D cytometry/ICPMS system was developed for evaluating drug uptake and induced protein expression inindividual cells. The nanoprobes conjugating 6-FAM-Sgc8 aptamers on a single AuNP were engineered to selectively bind PTK7 on target cells. PTK7 expression induced by OXA uptake was assayed with LIF,while ICP-MS measurement of 195Pt and 197Au revealed OXA uptake and AuNPs conjugation in single cells. Using a machine learning algorithm to cell-lines signature based on agent uptake and marker expression, it enables simultaneous online profiling PTK7 response to OXA at single-cell resolution from tumor cell lines and breast cancer patients.专家简介Professor Jian-Hua Wang was born in 1962 in Shandong, China. He obtained his B.Sc from Department of Chemistry, Nankai University, and M.Sc from Jilin University, China. He was awarded a PhD degree by Technical University of Denmark. He has been an Associate Editor for TALANTA since Dec. 2004. He is currently serving as the co-editor in chief for Talanta Open. He was a member of International Advisory Board for Journal of Analytical Atomic Spectrometry (2007-2010).His current research interest is focused on the exploitation of flow analysis protocols and hyphenation techniques, isolation of trace level of analytes (metals and biomacromolecules) from complex sample matrices and life science analysis, mainly focused on single cell analysis.报告摘要Surface-enhanced Raman scattering (SERS)-based assays have recently been developed to overcome the low detection sensitivity of SARS-CoV-2. In this study, we developed an SERS-based microdroplet sensor to dramatically improve the limit of detection (LoD) and reproducibility of SARS-CoV-2 detection. Raman signals were measured for SERS nanotags in 140 droplets as they passed through a laser focal volume fixed at the center of the channel for 15 seconds. In this case, the detection sensitivity has been significantly improved due to the ensemble averaging effects, as the signals were measured for SERS nanotags in multiple droplets. Moreover, the total assay time decreased from 30 to 10 minutes.A clinical test was conducted on patient samples to evaluate the clinical efficacy of the SERS-based microdroplet sensor. The assay results correlated well with those obtained using the RT-PCR method. The proposed SERS-based microdroplet sensor is expected to be utilized as a new point-of-care diagnostic platform for the quick and accurate detection of SARS-CoV-2 in the field.专家简介Jaebum Choo is a Professor in the Department of Chemistry at Chung-Ang University in South Korea. He obtained his PhD from Texas A&M University in 1994. From 1995 to 2019, he served as a faculty member at Hanyang University. In 2015, he was appointed as a Baik Nam Distinguished Professor, recognizing his outstanding academic accomplishments. In 2016, he served as the President of the Korea Biochip Society, and in 2020, he was the Chair of the Analytical Chemistry Division of the Korean Chemical Society. Currently, Professor Choo holds the position of Vice-President for Research at Chung-Ang University and serves as the Director of the "Center for Nanophotonics-based Biomedical Diagnostics Research Center (ERC)," which is supported by the National Research Foundation of Korea. His primary research areas include SERS, biosensors, micro-devices, and molecular spectroscopy. His ongoing research programs focus on the development of highly sensitive optical nano-sensor systems for rapid and precise in vitro diagnostics of infectious diseases. Throughout his career, Professor Choo has delivered over 150 invited lectures in the USA, Europe, and Asia. He has published more than 300 research papers in peer-reviewed journals and has contributed to eight book chapters.专家简介黄岩谊，北京大学化学学院教授，北京未来基因诊断高精尖创新中心、北京大学生物医学前沿创新中心、北大-清华生命科学联合中心研究员；兼任深圳湾实验室资深研究员。曾获得国家自然基金委优秀青年基金、杰出青年基金等资助。主要从事微量核酸分析研究，集中工作在测序技术、单细胞分析和微流控技术等方向。报告摘要器官芯片（Organ on a chip）是微流控技术与器官组织工程技术交叉融合发展的新兴技术。类器官（organoid）基于干细胞三维培养、分化获得的细胞三维组装体，包含其代表器官的一些关键特性，与对应的器官拥有类似的空间组织并能够重现对应器官的部分功能。类器官芯片（Organoid on a chip）是微流控技术与类器官技术交叉融合发展的新兴技术。器官芯片或类器官芯片模型有利于尽可能地接近和模拟人体实际生理病理条件下的微环境，应用于药物有效性和安全性评价，可能会以令人难以想象的幅度加快新药发现的周期，降低新药筛选失败的风险，给新药开发带来一次革命。专家简介清华大学长聘教授，长江学者特聘教授，兼任中国医药生物技术协会药物分析技术分会秘书长,中国分析测试协会青委会副主任委员，中国药理学会分析药理学专委会常务委员，北京理化分析测试技术学会副理事长兼青委会理事长等。研究方向聚焦于类器官与器官芯片、单细胞亚细胞分析、多组学分析及其在药学与中医药现代化研究中的应用。在包括Lab Chip, Anal. Chem., Nat. Protoc., Adv. Mater., Cell，PNAS等学术期刊发表SCI论文250余篇，获授权发明专利20余项，合作获得国家科技进步二等奖3项。报告摘要单颗粒光谱分析为精准实现特异性分析提供了新手段，具有灵敏度高、特异性好的有点。本课题组近年来以不同材质的单颗粒为基础，在研究其共振光散射光谱特性的基础上，并结合人工智能技术，实现了一系列有机光化学反应机制探讨，提出了不同于整体分析完全不一样的反应机制。专家简介黄承志，西南大学药物分析学/分析化学教授，博士生导师。先后获得西南师范大学、北京师范大学和北京大学的学、硕、博士学位，日立制作所中央研究所、渥太华大学和东京大学博士后。主持了包括国家杰出青年科学基金、国家自然科学基金重点及面上、973课题项目30多项，在JACS、Angew Chem、ACS Nano等刊物上发表论文500余篇，研究方向为共振光谱学与光谱分析。获教育部和重庆市自然科学一等奖各一项，获新世纪百千万人才工程第一层次、重庆巴渝学者、重庆优秀科学家等荣誉称号。报告摘要Microfluidic devices are widely used for analytical applications such as chemistry, biochemistry, and food science, and highly sensitive analytical methods have been developed. However, the macroworld-to-microworld interface is still challenging. Usually, the sample volume can be mL scale in conventional sampling methods, while it is difficult to treat the mL samples due to the nL to mL scale volume of the microchannels. If only the mL sample can be used for the analysis on microfluidic devices, the sample loss cancels the high sensitivity of the microfluidic devices. Therefore, the sampling interface is quite important to fully utilize the merits of microfluidic devices. Here, we propose a macroworld-to-microworld interface by creating a room-temperature quantitative concentration device. Room temperature operation is also an important condition to treat biological samples. Millimeter-to-micrometer channels are formed in a conventional microtube using a 3D fabrication, and air cyclone flow is used for room-temperature evaporation.专家简介Kazuma Mawatari is a professor of Graduate School of Information, Production and Systems at Waseda University. He has successful achievements in microfluidics and nanofluidics. Recently, he realized to integrate chemical processes in nano space by developing original methodologies as ultrasensitive detection, glass substrate low-temperature bonding, surface modification, etc. And ultrasensitive analytical devices were realized. For example, in single-cell analysis, he allowed an fL living cell sampling method and fL single molecule immunoassay (ELISA). He published 128 original papers and had 87 invited talks. He is currently an executive technical program committee (ETPC) member in uTAS, which is the largest international conference in micro/nanofluidics. 杨朝勇，国家杰出青年科学基金获得者、上海交通大学医学院分子研究员、厦门大学特聘教授、上海交通大学医学院分子医学研究院副院长、谱学分析与仪器教育部重点实验室副主任、中国化学会化学生物学专业委员会副主任、中国化学会分子医学专业委员会秘书长、英国皇家化学会Fellow、Analytical Chemistry副主编。主要研究领域为生物分析化学，在微流控、液体活检、单细胞测序、空间组学、体外诊断仪器与试剂、肠道菌群成像等方向取得了创新性的成果。在Nature Commun.、Sci. Adv.、PNAS、JACS、Angew. Chem. Int. Ed.等学术刊物上发表论文300余篇，论文被引超过20000次，H index=77，获授权发明专利65项,合著3本专业书籍。报告摘要In a typical drug screening test, single drugs or drug combinations with different types and concentrations need to be delivered to cell culture vessels. Here we developed a high-throughput drug delivery system using a disposable probe array with preloaded dried drugs for drug screening of tumor cells. A slot was fabricated at the tip of each probe in the probe array, where the drug solutions were quantitatively loaded, dried and preserved. With the probes carrying dried drugs, fast and efficient drug delivery can be easily realized for high-throughput cell-based drug screening.专家简介方群，浙江大学求是特聘教授，博士生导师，化学系微分析系统研究所所长，浙江大学杭州国际科创中心分子智造研究所所长，国家杰出青年基金获得者。自1998年开始从事微流控芯片分析的研究工作。目前研究方向包括微流控液滴分析和筛选，微流控液相色谱、质谱和毛细管电泳分析，微型化分析系统研制，人工智能+微流控系统，以及微流控系统在单细胞多组学分析、微量生化分析、药物筛选和现场分析中的应用。发表研究论文140余篇。在微流控分析领域有32项国家发明专利获得授权。曾主持承担国家基金委重大项目课题、国家杰出青年基金、国家基金重点项目、科学仪器研制专项和面上项目，以及国家科技部重点研发计划项目课题等科研项目。报告摘要
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