支架构型对脑动脉瘤流体力学特性的影响研究
Embolic coiling is the most popular endovascular treatment available for cerebral aneurysms. Nevertheless,the embolic coiling of wide-neck aneurysms is challenging and, in many cases, ineffective. Useof highly porous stents to support coiling of wide-neck aneurysms has become a common procedure inrecent years. Several studies have also demonstrated that high porosity stents alone can significantlyalter aneurysmal hemodynamics, but differences among different stent configurations have not beenfully characterized. As a result, it is usually unclear which stent configuration is optimal for treatment.In this paper, we present a flow study that elucidates the influence of stent configuration on cerebralaneurysm fluid dynamics in an idealized wide-neck basilar tip aneurysm model. Aneurysmal fluiddynamics for three different stent configurations (half-Y, Y and, cross-bar) were first quantified usingparticle image velocimetry and then compared. Computational fluid dynamics (CFD) simulations werealso conducted for selected stent configurations to facilitate validation and provide more detailedcharacterizations of the fluid dynamics promoted by different stent configurations. In vitro resultsshowed that the Y stent configuration reduced cross-neck flow most significantly, while the cross-barconfiguration reduced velocity magnitudes within the aneurysmal sac most significantly. The half-Yconfiguration led to increased velocity magnitudes within the aneurysmal sac at high parent-vesselflow rates. Experimental results were in strong agreement with CFD simulations. Simulated resultsindicated that differences in fluid dynamic performance among the different stent configurations can beattributed primarily to protruding struts within the bifurcation region.