BCEIA2023光谱学分会精彩预告：高灵敏光谱分析与成像
第二十届北京分析测试学术报告会暨展览会(BCEIA 2023) 将于2023年9月6-8日在北京中国国际展览中心(顺义馆)召开。BCEIA作为展示国际新技术、新仪器、新设备的窗口，一直以来受到国内外众多专家、学者、科技人员的关注，同时，学术报告会作为BCEIA重要组成部分，始终面向世界科技前沿。BCEIA 2023将举办大会报告、分会报告、高峰论坛、同期会议、墙报展等多场精彩学术活动，邀请国内外行业顶尖学者及学术带头人，分享最具前瞻性的研究进展，针对学科关注度最高的技术及应用进行研讨和交流。2023年9月7-8日，BCEIA2023学术报告会——光谱学分会将在学术会议区E-206会议室举行，聚焦“高灵敏光谱分析与成像”主题，围绕分子及纳米光谱、光谱分析与材料、高分辨光学成像、光谱仪与显微镜等主题方向，邀请到19位国内色谱领域资深科学家及青年才俊带来精彩报告。特邀报告人报告摘要Surface-enhanced Raman spectroscopy (SERS) has unique advantages for in vivo analysis, but still possesses significant challenges. Aiming to the key issues for in vivo SERS analysis, including complex environment, low molecular content and intermolecular interdependence, a series of novel semiconductor Raman substrates were uniquely constructed for highly sensitive, selective and multi-channel SERS analysis of molecules associated with Alzheimer's disease.First, by regulating the semiconductor energy level structure, we proposed a new SERS method that enhances the Ramansignal by promoting charge transfer through level matching and heterojunction blocking of electron-hole recombination, resulting in a 4-order of magnitude enhancement of the SERS enhancement factor to 1010 and establishing a highly sensitive in vivo analysis method. Secondly, we proposed a new strategy for triple recognition of molecular specificity, level matching, and fingerprint peaks, establishing a highly selective Raman analysis method for in vivo analysis, a SERS optophysiological probe was created for real-time mapping and recording of chemical and electrical signals without cross-talk in the live brain. Moreover, it was the first time that a Raman fiber photometry was built up for real-time tracking and simultaneous quantitation of multiple molecules in mitochondrial across the brain of free-moving animals. Meanwhile, a highly selective non-metallic Raman probe was created through triple-recognition strategies of chemical reaction, charge transfer, and characteristic fingerprint peaks, for monitoring and quantifying of local mitochondrial O2•-, Ca2+ and pH in six brain regions upon hypoxia. It was discovered that hypoxia-induced O2•- burst was regulated by ASIC1a, leading to mitochondrial Ca2+ overload and acidification.专家简介田阳，华东师范大学特聘教授，现任华东师范大学化学与分子工程学院院长。2013年曾获国家杰出青年基金资助；获日本化学会“The distinguished lectureship award”，中国分析测试协会一等奖(第一完成人)，中国化学会女分析化学家，上海市自然科学奖一等奖(第一完成人)；受邀在神经学和神经科学等国际国内做大会、主题或邀请报告36次。目前担任Chemical Communications副主编和《高等化学学报》副主编。田阳教授长期从事活体电信号的化学表达分析领域研究，在发展生物化学分子（如酶、蛋白等）的精准分析测量策略、建立长时程稳定的高空间分辨成像方法、及开拓高速成像分析新仪器等方面开展了深入和系统的工作。报告摘要Single-molecule detection enables the measurement of molecules at the single-molecule level, and it can be used to study the conformational changes and interaction between the molecules, holding great potential in biochemical analysis and biomedical research. In comparison with the conventional ensemble measurements, single-molecule detection possesses the advantages of ultrahigh sensitivity, good selectivity, rapid analysis, and low sample consumption. Single-molecule detection can be used as an ideal analytical approach to quantify the low-abundant biomolecules with rapidity and simplicity. We demonstrate the applications of single-molecule detection-based biosensors for sensitive detection of various target biomolecules such as long noncoding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs). The biosensors show extremely high sensitivity. Moreover, these biosensors enable simultaneous measurement of multiple endogenous RNAs at the single-cell level, and it may discriminate the expressions of various RNAs in lung tumor tissues and the healthy tissues, offering a promising platform for clinical diagnosis and biomedical research.专家简介Chun-yang Zhang obtained his PhD degree from Peking University, China, in 1999. During 1999–2008, he worked at Tsinghua University, China Emory University, USA The Johns Hopkins University, USA and The City University of New York, USA. In 2009, he joined as a professor in the Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, China. During 2015-2023, he worked as the dean of college of Chemistry, Chemical Engineering and Material Science in Shandong Normal University, China. In 2023, he joins in Southeast University, China. He is the recipient of the China National Fund for Distinguished Young Scientists. His research focuses on analytical chemistry, bioelectrochemistry, bionanotechnology and single-molecule detection.报告摘要Marine plankton play important role in ocean biogeochemistry, and their observation is of fundamental significance for oceanographic research and coastal environment monitoring. However, current marine plankton observation still relies heavily on traditional manual net sampling and optical microscopy inspection, which has long been notoriously slow and labor intensive. Developing automated and online approaches for this task is expected to satisfy the urgent needs from marine scientists for research and government departments for operational oceanographic coastal seawater environment monitoring. The advent and application of in situ optical imaging have enabled more direct observations of marine plankton in different tempo-spatial scales, greatly promoted our understanding of marine plankton ecology. However, existing underwater plankton cameras compromise between their imaging resolution and field of view (FOV) for in situ observations. In order to enlarge the sampling volume in single frame acquisition, they usually adopt lower magnifications to enable larger FOV but sacrifice the resolution. This will inevitably lead to a decreased imaging resolution, leading to insufficiency to obtain enough image details for the relatively small plankton targets and hence inaccuracy for subsequent species identification and quantification.In this talk, the speaker will report some recent developments by his team on in situ plankton imaging technologies. Particularly, the talk will emphasize a deep learning-based super-resolution in situ plankton imaging technology. This new technique is expected to enhance the existing plankton imageries and enable future underwater plankton imaging instruments for better in situ plankton observation and hence deeper our understanding of the marine plankton ecology.专家简介李剑平，男，博士，中国科学院深圳先进技术研究院正高级工程师，中国科学院大学博士生导师，深圳市海洋声光探测技术及装备工程研究中心主任。研究领域包括创新光学方法、先进光电仪器、机器视觉与机器学习在海洋观测中的应用。先后主持和参与了国家重点研发计划、国家自然科学基金、中国科学院、香港大学教育资助局(RGC)、广东省科技厅、深圳市科技创新委等研究项目。带领团队研制了水下浮游生物成像仪、走航式浮游植物成像流式细胞仪、海水叶绿素a、COD、BOD传感器等多种海洋观测探测仪器。在IEEE JOE，ICES JMS, FMARS，ECCV，ICCV， Optics Letters, Optics Express、Applied Optics等光学、海洋科学和机器视觉知名期刊和国际学术会议发表论文多篇，申请中国发明专利和实用新型专利43项，获得发明专利授权7项，实用新型专利授权6项；在ICCV, Ocean Optics, International Ocean Color Sciences, Focus on Microscopy等知名国际会议做主旨报告、口头报告多次。李剑平博士是国际电子电气工程协会IEEE高级会员、美国光学学会Optica会员、国际光电工程师协会SPIE会员、国际海洋技术学会MTS会员、中国仪器仪表学会高级会员、中国海洋与湖沼学会海洋观测分会理事、中国海洋湖沼学会海洋腐蚀与污损专业委员会委员、深圳市人工智能学会会员、广东省自然资源厅赤潮专家库专家。长期担任Optics Letters, Optics Express, Biomedical Optics Express, Applied Spectroscopy, Applied Optics, Cytometry Part A等知名学术期刊论文审稿人，担任国际会议ICCV Computer Vision in the Ocean Workshop程序委员会委员和审稿人。报告摘要The advanced light source (ALS) analytical technologies have been expanded to dig into the underexplored behavior and fate of nanomedicines in vivo. It is increasingly important to further develop ALS-based analytical technologies with higher spatial and temporal resolution, multimodal data fusion, and intelligent prediction abilities to deeply unlock the potential of nanomedicines. In this presentation, we focus on several selected ALS analytical technologies, including imaging and spectroscopy, and provide an overview of the emerging opportunities for their applications in exploring the biological behavior and fate of nanomedicines.Improved ALS imaging and spectroscopy techniques will accelerate a profound understanding of the biological behavior of new nanomedicines.专家简介王亚玲，国家纳米科学中心研究员，广州市新发传染病疫苗研发技术创新促进会理事，主要研究方向为基于先进光源的纳米生物分析方法、新型纳米佐剂开发及产业化研究。近年来，在Nature protocols, Acc. Chem. Res., ACS Cent. Sci., Nano Today, Anal. Chem., ACS Nano,等期刊上发表70余篇论文，申请发明专利18项，获授权国家发明专利3项。作为首席科学家承担了科技部政府间科技合作重点专项，主持了国家重点研发计划大科学装置专项课题1项，国家自然科学基金青年、面上、重点项目子课题各1项，作为项目骨干参加中科院先导B项目、纳米生物效应及分析方法等相关十多个项目研究。报告摘要Molecular sensing and imaging have become powerful tools in both fundamental research and clinical diagnosis because they enable not only to quantify but also to track biological molecules of interest. During the past years, we are dedicated to developing new strategies that enable spatiotemporally selective molecular sensing with higher precision. For example, by designing light-activatable sensors and combining it with upconversion nanotechnology, spatiotemporally controlled imaging of metal ions in mitochondria was achieved. In addition,ly requires high power illumination that could damage the biological specimen. We report that integral imaging with surface plasmon polaritons allows single-protein detection with a signal-to-noise ratio an-order-of-magnitude beyond the shot-noise limit. Therefore, our integral microscopy allows quantitative mass imaging and binding analysis of single unlabeled protein molecules with a three-orders-of-magnitude reduction in the light intensity. It also enables highly specific protein detection at the subpicomolar concentration level that would not otherwise be achievable.专家简介2011年博士毕业于浙江大学，并先后在香港科技大学和美国亚利桑那州立大学开展研究工作。2017年加入上海交通大学生物医学工程学院，主要研究方向为光学生物传感技术及仪器。在PNAS等顶级期刊发表多篇学术论文，承担基金委国家重大科研仪器研制项目、十四五国家重点研发计划专项课题、基金委面上项目等研究任务。以上报告内容由BCEIA2023组委会提供欢迎扫码报名参加BCEIA2023
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