An RSLC-MS/MS method for quantitative analysis of five ethanolamines was developed and described. By using a mixed-mode analytical column and selective MRM MS/MS detection, this method showed significant improvements over previously reported methods with minimum sample preparation, totalchromatographic resolution, capability of sub-ppb level quantification, and high throughput. Application of this method to the analysis of surface waters was demonstrated and showed no quantifiable amounts above the LRLs. Matrix effects and recovery were evaluated using two surface water matrices and the results indicated better quantitation accuracy for DEA by using an isotope labeled analogue as an internal standard.
辣木籽提取物对大肠杆菌的抑制作用Inhibitory Power of Moringa (Moringa oleifera) Seed Extract from Various Levels of Maturity on Eschericia coli bacteria使用格哈特Vapodest 45s以及Turbosog涤气系统和消化系统测定蛋白质含量Vapodest 45s已升级为Vapodest 450
During biosysnthesis, various post-translational modifi cations (PTMs) will lead to charge heterogeneity in monoclonal antibody (mAb) products. Due to these modifi cations, charge variants can affect the biological properties of mAbs as biotherapeutics. Hence it is very important to monitor this quality attribute during bioprocessing for lot-to-lot consistency and stability. Capillary electrophoresis (CE) with charge to mass based separation mechanism, is best situated for separation of charged molecules. Due to difference in net charge of the charge variants, their electrophoretic mobility differs, resulting in capillary zone electrophoresis (CZE) separation1,2. This Application Note demonstrates the feasibility of using CZE for monitoring the charge variants of innovator and biosimilar rituximab on Agilent 7100 CE system. Further, the basic charge variants of biosimilar rituximab were characterized by CZE/MS.