来那替尼

Acclaim Trinity P1混合模式色谱柱技术中最具创新的一大进步：单一填料具备反相、阴离子和阳离子交换功能 是同时分离 API 和对离子的理想选择 可通过流动相离子强度、电解质类型、pH 以及有机溶剂调节选择性 低流失，兼容 MS, CAD 和 ELSD 无需离子对试剂也可保留离子和可离子化的分析物 为方法开发提供更大灵活性：可单独控制每种保留机制Thermo Scientific? Acclaim? Trinity? P1 HPLC 色谱柱采用独特的多模式表面化学键合相，非常适合同时分离药物及其对离子。表面化学键合相同时提供反相、阳离子交换和阴离子交换功能。这为方法开发提供了极大的灵活性。可通过调节色谱参数(流动相pH、离子强度和有机强度)来优化分离。Acclaim Trinity P1 固定相采用纳米杂化硅聚合物 (NSH) 技术，由包有带电荷纳米高分子微球的高纯多孔球形 3μm 硅胶颗粒组成。硅胶孔内的键合相同时具有反相和阴离子交换特性，而硅胶外部的微球具有阳离子交换功能。订货信息：

Acclaim Trinity P1混合模式色谱柱技术中最具创新的一大进步：单一填料具备反相、阴离子和阳离子交换功能 是同时分离 API 和对离子的理想选择 可通过流动相离子强度、电解质类型、pH 以及有机溶剂调节选择性 低流失，兼容 MS, CAD 和 ELSD 无需离子对试剂也可保留离子和可离子化的分析物 为方法开发提供更大灵活性：可单独控制每种保留机制Thermo Scientific? Acclaim? Trinity? P1 HPLC 色谱柱采用独特的多模式表面化学键合相，非常适合同时分离药物及其对离子。表面化学键合相同时提供反相、阳离子交换和阴离子交换功能。这为方法开发提供了极大的灵活性。可通过调节色谱参数(流动相pH、离子强度和有机强度)来优化分离。Acclaim Trinity P1 固定相采用纳米杂化硅聚合物 (NSH) 技术，由包有带电荷纳米高分子微球的高纯多孔球形 3μm 硅胶颗粒组成。硅胶孔内的键合相同时具有反相和阴离子交换特性，而硅胶外部的微球具有阳离子交换功能。订货信息：

产品特点：Acclaim™ Trinity P1 LC 色谱柱采用高效 Thermo Scientific™ Acclaim™ Trinity P1 LC 色谱柱，同步分离药物成分及其对离子。 独特的三重表面化学作用为最大程度提高方法开发灵活性提供并行反相、阳离子交换和阴离子交换功能。 通过调整流动相缓冲液浓度、pH 和溶剂含量（混合或单独）轻松优化选择性，以加速色谱分离，提高生产率。Acclaim Trinity P1 固定相采用纳米杂化硅聚合物 (NSH) 技术，由包被有带电荷纳米高分子微球的高纯多孔球形 3 μm 硅胶颗粒组成。 这种独特的表面化学作用包括经有机层改性的内部微孔区域，能同时提供反相和阴离子交换特性。 相反，外部微孔表面经阳离子交换功能改性，拥有无与伦比的色谱性能。 制药应用的优异性能理想选择性，适用于同步分离活性药物成分 (API) 和对离子（碱性、中性和酸性分析物）无需离子对试剂也可保留亲水离子和可离子化分析物 阴离子交换和阳离子交换区域的特殊空间分离通过单独可控每种保留机制实现灵活的方法开发低柱流失；与质谱仪 (MS)、电雾式检测器 (CAD) 和蒸发光散射检测器 (ELSD) 兼容 备有直径为 2.1 和 3.0 mm、长度为 50、100 和 150 mm 的选项可供选择Acclaim Trinity P2 色谱柱与 Acclaim Trinity P1 色谱柱互补，为 HPLC 制药对离子分析提供全面的解决方案。 使用 Acclaim Trinity P2 色谱柱分离对离子，包括一价和二价阳离子或阴离子。关于 Acclaim Specialty HPLC 色谱柱系列Acclaim 专用色谱柱专为满足具体应用的分离需求而进行开发、制造和测试。 这些色谱柱基于新式、独特的化学作用，可提供优越的分离度和易用性。经测试可确保一致的分离具有理想选择性，适用于分离特定的靶向分析物出色的峰形 其性能经过测试，可确保高质量和可靠性的特定色谱分离Acclaim Trinity P1Mixed mode column technology combining reversed-phase, anion exchange and cation exchange functionality on a single support* Ideal selectivity for simultaneous separation of API and counterion* Adjustable selectivity by mobile phase ionic strength, electrolyte type, pH, and organic solvent* Low bleed compatible with MS, CAD and ELSD* Retention of hydrophilic ionic and ionizable analytes without ion-pairing reagents* Greater flexibility in method development: each retention mechanisms can be controlled independentlyThe Thermo Scientific™ Acclaim™ Trinity™ P1 HPLC column is designed with Nanopolymer Silica Hybrid (NSH) technology, which results in a multimode surface chemistry ideal for the simultaneous separation of drugs and their counterions. The surface chemistry concurrently provides reversed-phase, cation exchange, and anion exchange functionalities. The result is maximum flexibility in method development. Separations can be optimized easily by adjusting the chromatographic parameters (mobile phase pH, ionic strength, and organic strength).订购信息：Acclaim Trinity P1Particle Size (μm)FormatLength (mm)2.1mm ID3.0mm ID3 Guard Cartridges(2/pk)10 071391 071390 HPLC Column 50075565071388100071389071387150075564075563Acclaim Guard HolderFormatCat.No.Acclaim SST Guard Cartridge Holder V-2069580Acclaim Guard Kit (Holder and coupler) V-2069707Guard to Analytical Column Coupler V-2074188

产品特点：Acclaim™ Trinity P2 液相色谱柱Thermo Scientific™ Acclaim™ Trinity P2 液相色谱柱可用来分离包括一价和二价阳离子或阴离子在内的药物反离子。这种创新性混合模式色谱柱技术可提供基于亲水作用、HILIC、阴离子交换和阳离子交换的色谱技术，从而可灵活进行方法开发。Acclaim Trinity P2 液相色谱柱与 Acclaim Trinity P1 液相色谱柱相互补充，可同步分离多种药物成分及其反离子，从而可提供一种使用高效液相色谱进行药物反离子分析的整体解决方案。Acclaim Trinity P2 固定相采用纳米杂化硅聚合物 (NSH) 技术，由包被有带电纳米聚合物微粒的高纯、多孔、球形硅胶颗粒组成。这种独特的表面化学结构包含一个经过共价键合型有机层修饰的硅珠内孔区域，该有机层具有阳离子交换保留功能。外孔表面使用阴离子交换型纳米聚合物微珠进行修饰。这种化学结构可确保阴离子交换区和阳离子交换区在空间上实现分离。对反离子分析具有高选择性柱流失率低；与质谱（MS）和荷电气溶胶检测（CAD）技术兼容水解稳定高效提供以下规格：粒径，3.0μm；直径，2.1mm 和 3.0mm；长度，50mm 和 100mm关于 Acclaim Specialty HPLC 色谱柱系列Acclaim 专用色谱柱专为满足具体应用的分离需求而进行开发、制造和测试。这些色谱柱基于新式、独特的化学作用，可提供出色的分离度 和易用性。经过测试可确保一致的分离具有理想选择性，适用于分离特定的靶向分析物出色的峰形其性能经过测试，可确保高质量和可靠性的特定色谱分离Acclaim Trinity P2Mixed-mode column technology hydrophilic interaction combining HILIC, anion exchange and cation exchange functionalities* Ideal for separating pharmaceutical counterions, including monovalent and divalent cations or anions* Selectivity complementary to the Trinity P1 column * Low column bleed, compatible with CAD and MS* Hydrolytically stable* High efficiencyThe Acclaim Trinity P2 is a unique, high-efficiency, silica-based column specifically designed for separation of pharmaceutical counterions, including monovalent and divalent cations or anions. This column is based on Nanopolymer Silica Hybrid (NSH) technology, which consists of high-purity porous spherical silica particles coated with charged nanopolymer particles. The inner-pore area of the silica bead is modified with a covalently bonded organic layer that provides cation-exchange retention, while the outer surface is modified with anion-exchange nano-polymer beads. Acclaim Trinity P2 column is aimed to complement Acclaim Trinity P1 to provide a total solution for pharmaceutical counter ion analysis by HPLC.订购信息：Acclaim Trinity P2Particle Size (μm)FormatLength (mm)2.1mm ID3.0mm ID3Guard Cartridges(2/pk)10 085435 085436 HPLC Column 50085431085433100085432085434Acclaim Guard HolderFormatCat.No.Acclaim Guard Cartridge Holder V-2069580Acclaim Guard Kit (Holder and coupler) V-2069707Guard to Analytical Column Coupler V-2074188

Acclaim Trinity P2 液相色谱柱Thermo ScientificAcclaimTrinity P2 液相色谱柱可用来分离包括一价和二价阳离子或阴离子在内的药物反离子。 这种创新性混合模式色谱柱技术可提供基于亲水作用、HILIC、阴离子交换和阳离子交换的色谱技术，从而可灵活进行方法开发。 Acclaim Trinity P2 液相色谱柱与 Acclaim Trinity P1 液相色谱柱相互补充，可同步分离多种药物成分及其反离子，从而可提供一种使用高效液相色谱进行药物反离子分析的整体解决方案。描述Acclaim Trinity P2 固定相采用纳米杂化硅聚合物 (NSH) 技术，由包被有带电纳米聚合物微粒的高纯、多孔、球形硅胶颗粒组成。 这种独特的表面化学结构包含一个经过共价键合型有机层修饰的硅珠内孔区域，该有机层具有阳离子交换保留功能。 外孔表面使用阴离子交换型纳米聚合物微珠进行修饰。 这种化学结构可确保阴离子交换区和阳离子交换区在空间上实现分离。对反离子分析具有高选择性 柱流失率低；与质谱（MS）和荷电气溶胶检测（CAD）技术兼容水解稳定高效提供以下规格：粒径，3.0μm；直径，2.1mm 和 3.0mm；长度，50mm 和 100mm关于 Acclaim Specialty HPLC 色谱柱系列Acclaim 专用色谱柱专为满足具体应用的分离需求而进行开发、制造和测试。 这些色谱柱基于新式、独特的化学作用，可提供出色的分离度 和易用性。经过测试可确保一致的分离具有理想选择性，适用于分离特定的靶向分析物出色的峰形其性能经过测试，可确保高质量和可靠性的特定色谱分离Acclaim Trinity P2订货信息：Analytical ColumnsAcclaim Trinity P2,3μm,Analytical column, 3.0 x 50mm085433Acclaim Trinity P2,3μm,Analytical column, 3.0 x 100mm085434Acclaim Trinity P2,3μm,Analytical column, 2.1 x 50mm085431Acclaim Trinity P2,3μm, Analytical column, 2.1 x 100mm085432Guard ColumnsAcclaim Trinity P2,3μm,Guard column, 3.0 x 10mm, 2/pk requires holder 069580085436Acclaim Trinity P2,3μm,Guard column, 2.1 x 10mm, 2/pk requires holder 069580085435Acclaim SST Guard Cartridge Holder V-2069580Acclaim Guard Kit (Holder and coupler) V-2609707Guard to Analytical Column Coupler V-2The Thermo Scientific? Acclaim? Trinity? P2 column is a high-performance, silica-based column specifically designed for separation of pharmaceutical mono- and multi-valent counterions by high-performance liquid chromatography (HPLC). This column was engineered for analytical chemists who need simple, robust, fast, generic methods. The Acclaim Trinity P2 columns provide an effective solution for counterion analysis using one column and one method on a standard HPLC instrument.? Desired selectivity for pharmaceutical mono- and multi-valent counterion screening? Retention of ionic and ionizable analytes without using ion-pairing reagents? Compatibility with charged aerosol and mass spectrometry detection methods? Easy to use? Rugged packingThe Acclaim Trinity P2 column is based on nanopolymer silica hybrid (NSH) technology. It consists of high-purity, porous, 3 μm particles coated with charged nanopolymer particles: the innerpore area of the silica particles is modified with a covalently bonded hydrophilic layer that provides cation exchange retention, while the outer surface is modified with anion-exchange nanopolymer beads. This chemistry design ensures spatial separation of the anion exchange and cation exchange regions. In addition, its hydrophilic surface makes it useful as a hydrophilic interaction liquid chromatography (HILIC) column. Thus, the Acclaim Trinity P2 column provides cation-exchange, anion-exchange, and HILIC retentions on the same stationary phase.NSH Chromatographic FeaturesMultiple retention mechanisms including HILIC, anion-exchange, and cation-exchangeAdjustable selectivity by mobile phase ionic strength, electrolyte type, pH, and organic solventIdeal selectivity for simultaneous separation of basic, neutral, and acidic analytesSeparation of hydrophilic ionic and ionizable analytes without ion-pairing reagentsAcclaim Trinity P2 Column – Superior Performance for Pharmaceutical Applications SpecificationsColumn chemistrySAX, WCX and HILIC Mixed-ModeOperating pressure limit6000 psiOperating pH range2.0 – 8.0Operating flow rate range0.3 – 0.90 mL/min for 3.0-mm i.d. formats0.15 – 0.45 mL/min for 2.1-mm i.d. formatsOrganic compatibilityCompatible with most common HPLC organic solvents except for alcohols.Aqueous compatibility0-100% aqueous mobile phaseStorage solutionMeCN/10mM NH4OAc, pH5 v/v 90/10 or pure MeCN (acetonitrile) Separation of 12 common pharmaceutical counterions (both anions and cations) in less than 15 minutes using the Trinity P2 column. Separation of a hydrophilic drug and counterion under HILIC conditions.Data SheetsThermo Scientific Acclaim Trinity P2 Columns Ideal Solution for Pharmaceutical Counterion AnalysisManualsThermo Scientific Acclaim Trinity P2 Column Product ManualAcclaim Trinity P2 Columns Quick StartApplication NotesAN 20977: Separation of Biochemical Buffering Agents Using Multi-Mode Liquid Chromatography with Charged Aerosol DetectionSeparation of Calcium, Magnesium and Counterions in a Dietary Supplement Using Multi-mode Liquid Chromatography with Charged Aerosol DetectionAPI and Counterions in Adderall Using Multi-mode Liquid Chromatography with Charged Aerosol DetectionSimultaneous Determination of Metformin and its Chloride Counterion Using Multi-Mode Liquid Chromatography with Charged Aerosol DetectionAnalysis of a Sports Beverage for Electrolytes and Sugars Using Multi-Mode Chromatography with Charged Aerosol Detection

Acclaim Trinity P1混合模式色谱柱技术中最具创新的一大进步：单一填料具备反相、阴离子和阳离子交换功能 是同时分离 API 和对离子的理想选择 可通过流动相离子强度、电解质类型、pH 以及有机溶剂调节选择性 低流失，兼容 MS, CAD 和 ELSD 无需离子对试剂也可保留离子和可离子化的分析物 为方法开发提供更大灵活性：可单独控制每种保留机制Thermo Scientific? Acclaim? Trinity? P1 HPLC 色谱柱采用独特的多模式表面化学键合相，非常适合同时分离药物及其对离子。表面化学键合相同时提供反相、阳离子交换和阴离子交换功能。这为方法开发提供了极大的灵活性。可通过调节色谱参数(流动相pH、离子强度和有机强度)来优化分离。Acclaim Trinity P1 固定相采用纳米杂化硅聚合物 (NSH) 技术，由包有带电荷纳米高分子微球的高纯多孔球形 3μm 硅胶颗粒组成。硅胶孔内的键合相同时具有反相和阴离子交换特性，而硅胶外部的微球具有阳离子交换功能。订货信息：

Acclaim Trinity P1混合模式色谱柱技术中最具创新的一大进步：单一填料具备反相、阴离子和阳离子交换功能 是同时分离 API 和对离子的理想选择 可通过流动相离子强度、电解质类型、pH 以及有机溶剂调节选择性 低流失，兼容 MS, CAD 和 ELSD 无需离子对试剂也可保留离子和可离子化的分析物 为方法开发提供更大灵活性：可单独控制每种保留机制Thermo Scientific? Acclaim? Trinity? P1 HPLC 色谱柱采用独特的多模式表面化学键合相，非常适合同时分离药物及其对离子。表面化学键合相同时提供反相、阳离子交换和阴离子交换功能。这为方法开发提供了极大的灵活性。可通过调节色谱参数(流动相pH、离子强度和有机强度)来优化分离。Acclaim Trinity P1 固定相采用纳米杂化硅聚合物 (NSH) 技术，由包有带电荷纳米高分子微球的高纯多孔球形 3μm 硅胶颗粒组成。硅胶孔内的键合相同时具有反相和阴离子交换特性，而硅胶外部的微球具有阳离子交换功能。订货信息：

Acclaim Trinity P1混合模式色谱柱技术中最具创新的一大进步：单一填料具备反相、阴离子和阳离子交换功能 是同时分离 API 和对离子的理想选择 可通过流动相离子强度、电解质类型、pH 以及有机溶剂调节选择性 低流失，兼容 MS, CAD 和 ELSD 无需离子对试剂也可保留离子和可离子化的分析物 为方法开发提供更大灵活性：可单独控制每种保留机制Thermo Scientific? Acclaim? Trinity? P1 HPLC 色谱柱采用独特的多模式表面化学键合相，非常适合同时分离药物及其对离子。表面化学键合相同时提供反相、阳离子交换和阴离子交换功能。这为方法开发提供了极大的灵活性。可通过调节色谱参数(流动相pH、离子强度和有机强度)来优化分离。Acclaim Trinity P1 固定相采用纳米杂化硅聚合物 (NSH) 技术，由包有带电荷纳米高分子微球的高纯多孔球形 3μm 硅胶颗粒组成。硅胶孔内的键合相同时具有反相和阴离子交换特性，而硅胶外部的微球具有阳离子交换功能。订货信息：

Acclaim Trinity P1混合模式色谱柱技术中最具创新的一大进步：单一填料具备反相、阴离子和阳离子交换功能 是同时分离 API 和对离子的理想选择 可通过流动相离子强度、电解质类型、pH 以及有机溶剂调节选择性 低流失，兼容 MS, CAD 和 ELSD 无需离子对试剂也可保留离子和可离子化的分析物 为方法开发提供更大灵活性：可单独控制每种保留机制Thermo Scientific? Acclaim? Trinity? P1 HPLC 色谱柱采用独特的多模式表面化学键合相，非常适合同时分离药物及其对离子。表面化学键合相同时提供反相、阳离子交换和阴离子交换功能。这为方法开发提供了极大的灵活性。可通过调节色谱参数(流动相pH、离子强度和有机强度)来优化分离。Acclaim Trinity P1 固定相采用纳米杂化硅聚合物 (NSH) 技术，由包有带电荷纳米高分子微球的高纯多孔球形 3μm 硅胶颗粒组成。硅胶孔内的键合相同时具有反相和阴离子交换特性，而硅胶外部的微球具有阳离子交换功能。订货信息：

Acclaim Trinity P1混合模式色谱柱技术中最具创新的一大进步：单一填料具备反相、阴离子和阳离子交换功能 是同时分离 API 和对离子的理想选择 可通过流动相离子强度、电解质类型、pH 以及有机溶剂调节选择性 低流失，兼容 MS, CAD 和 ELSD 无需离子对试剂也可保留离子和可离子化的分析物 为方法开发提供更大灵活性：可单独控制每种保留机制Thermo Scientific? Acclaim? Trinity? P1 HPLC 色谱柱采用独特的多模式表面化学键合相，非常适合同时分离药物及其对离子。表面化学键合相同时提供反相、阳离子交换和阴离子交换功能。这为方法开发提供了极大的灵活性。可通过调节色谱参数(流动相pH、离子强度和有机强度)来优化分离。Acclaim Trinity P1 固定相采用纳米杂化硅聚合物 (NSH) 技术，由包有带电荷纳米高分子微球的高纯多孔球形 3μm 硅胶颗粒组成。硅胶孔内的键合相同时具有反相和阴离子交换特性，而硅胶外部的微球具有阳离子交换功能。订货信息：

Acclaim Trinity P2最新的混合模式色谱柱技术，具有亲水相互作用、HILIC、阴离子交换和阳离子交换功能 分离药物对离子，包括单价和二价阴离子和阳离子 选择性与 Trinity P1 色谱柱互补 低柱流失，与 CAD 和 MS 兼容 水解稳定 高柱效Acclaim Trinity P2 是独特的、高柱效、硅胶基质的色谱柱，是专用于药物对离子(包括单价和二价阴离子和阳离子)分析的色谱柱。Acclaim Trinity P2 色谱柱基于 NSH 技术, 由包有带电荷纳米高分子微球的高纯多孔球形 3μm 硅胶颗粒组成。硅胶孔内的键合相具有阳离子交换作用，而外部微孔则具有阴离子交换功能。这种键合相具有阴离子交换和阳离子交换功能。Acclaim Trinity P2 色谱柱与 Acclaim Trinity P1 互补，可在 HPLC 上完成药物对离子的分离。订货信息：

Acclaim Trinity Q1 液相色谱柱Acclaim Trinity Q1 采用专利的纳米微球- 硅胶杂化技术（NSH），一个颗粒上集成了三种分离模式，专门用于敌草快/ 百草枯的分析。可靠性和耐用性质量和可靠性对确保成功分析至关重要。每个 Acclaim 色谱柱都经过大量测试，因此色谱工作者们在使用时可充满信心。制造过程始于超纯硅胶基质，我们仅挑选符合严格物理参数的批次。独特的设计使得键合过程清洁、可重复，不会出现意外的性能变化。每一键合硅胶批次都经过针对其预期用途的全套验证测试。键合硅胶采用高度可靠工艺装填于精密抛光的 316 不锈钢硬件中。每根装填的色谱柱都经过测试以确保每次使用都能获得出色性能。针对硅胶批次验证和色谱柱性能的分析认证报告说明测试方案、列出了分析方法、色谱柱规格，并提供实际色谱图。性能指标Acclaim 色谱柱满足当今实验室所需的高质量标准。创新的表面化学键合相对多种分析物提供优异的峰形和柱效。为确保最优性能，所有 Acclaim 产品都使用多个性能指标进行充分表征，包括键合相表面覆盖率、金属杂质、空间选择性、柱极性、柱疏水性以及针对碱类的低硅醇基活性。专用柱还经过了针对其专用分析的应用测试，以确保每一批次的键合硅胶都能提供高性能分离。Acclaim Trinity Q1 液相色谱柱订货信息：Analytical ColumnsAcclaim Trinity Q1, 3μm Analytical, (2.1 x 50mm)083242Acclaim Trinity Q1, 3μm, Analytical (3.0 x 50mm)083241Guard ColumnsAcclaim Trinity Q1, 5μm, Guard (2.1 x 10mm) 2 ea requires holder 069580083244Acclaim Trinity Q1, 5μm, Guard (3.0 x 10mm) 2 ea requires holder 069580079719Acclaim SST Guard Cartridge Holder V-2069580Acclaim Guard Kit (Holder and coupler) V-2069707Guard to Analytical Column Coupler V-2074188 Separation of Diquat and ParaquatThermo Scientific? Acclaim? Trinity? Q1 columns are unique, high-efficiency, silica-based columns designed for the separation of the herbicides diquat and paraquat. These quaternary amines are widely used as nonselective contact herbicides. Due to their toxicity, they are monitored in drinking water and wastewater for agricultural exposure. The Acclaim Trinity Q1 columns can quickly and easily separate these compounds. The separation is compatible with mass spectrometry detection, which significantly improves sensitivity for the analytes and provides conformation at the same time.Column features include:Excellent resolution of diquat and paraquatGood peak shapeFast analysisLC/MS compatibilityNo ion-pairing reagent neededEase of useThis new column, based on Nanopolymer Silica Hybrid (NSH) technology, provides multiple retention mechanisms, including reversed-phase, anion-exchange, and cation-exchange. The NSH technology ensures distinctive spatial separation of the anion-exchange and cation-exchange regions, which results in maximum flexibility in method development. The chromatography can be easily optimized by adjusting mobile phase buffer concentration, pH, and solvent content, concurrently or independently. The easy-to-optimize selectivity can be used to accelerate chromatographic separations and increase productivity.Nano Silica Hybrid (NSH) Chromatographic FeaturesMultiple retention mechanisms, including reversed-phase, anion-exchange, and cation-exchangeAdjustable selectivity by mobile phase ionic strength, electrolyte type, pH, and organic solventIdeal selectivity for simultaneous separation of basic, neutral, and acidic analytesSeparation of hydrophilic ionic and ionizable analytes without ion-pairing reagentAcclaim Trinity Q1 Column – SpecificationsColumn chemistryWCX, WAX and RP Mixed-ModeBase materialSpherical, high-purity, porous silicaParticle size3 μmSurface area100 m2/gPore size300 ?Operating pressure limit4000 psiOperating pH range2.5–7.0Operating flow rate range0.3 – 0.90 mL/min for 3.0 mm i.d. formats0.15–0.45 mL/min for 2.1 mm i.d. formatsLC/UV Separation of Diquat andParaquat LC/MS/MS Separation of Diquat and ParaquatData SheetsAcclaim Trinity Q1 Columns for Trace Analysis of Diquat and Paraquat Product SpecificationsManualsThermo Scientific Acclaim Trinity Q1 Product ManualAcclaim Trinity Q1 QuickStartPostersSimultaneous Determination of Paraquat and Diquat in Environmental Water Samples by HPLC-MS/MSApplication NotesAN 1051: Sensitive and Rapid Determination of Paraquat and Diquat in Tap and Environmental Waters

Acclaim Trinity P2 LC ColumnThe Thermo Scientific™ Acclaim™ Trinity™ P2 column is a high-performance, silica-based column specifically designed for separation of pharmaceutical mono- and multi-valent counterions by high-performance liquid chromatography (HPLC). This column was engineered for analytical chemists who need simple, robust, fast, generic methods. The Acclaim Trinity P2 columns provide an effective solution for counterion analysis using one column and one method on a standard HPLC instrument.? Desired selectivity for pharmaceutical mono- and multi-valent counterion screening? Retention of ionic and ionizable analytes without using ion-pairing reagents? Compatibility with charged aerosol and mass spectrometry detection methods? Easy to use? Rugged packingThe Acclaim Trinity P2 column is based on nanopolymer silica hybrid (NSH) technology. It consists of high-purity, porous, 3 μm particles coated with charged nanopolymer particles: the innerpore area of the silica particles is modified with a covalently bonded hydrophilic layer that provides cation exchange retention, while the outer surface is modified with anion-exchange nanopolymer beads. This chemistry design ensures spatial separation of the anion exchange and cation exchange regions. In addition, its hydrophilic surface makes it useful as a hydrophilic interaction liquid chromatography (HILIC) column. Thus, the Acclaim Trinity P2 column provides cation-exchange, anion-exchange, and HILIC retentions on the same stationary phase.NSH Chromatographic FeaturesMultiple retention mechanisms including HILIC, anion-exchange, and cation-exchangeAdjustable selectivity by mobile phase ionic strength, electrolyte type, pH, and organic solventIdeal selectivity for simultaneous separation of basic, neutral, and acidic analytesSeparation of hydrophilic ionic and ionizable analytes without ion-pairing reagentsAcclaim Trinity P2 Column – Superior Performance for Pharmaceutical Applications SpecificationsColumn chemistrySAX, WCX and HILIC Mixed-ModeOperating pressure limit6000 psiOperating pH range2.0 – 8.0Operating flow rate range0.3 – 0.90 mL/min for 3.0-mm i.d. formats0.15 – 0.45 mL/min for 2.1-mm i.d. formatsOrganic compatibilityCompatible with most common HPLC organic solvents except for alcohols.Aqueous compatibility0-100% aqueous mobile phaseStorage solutionMeCN/10mM NH4OAc, pH5 v/v 90/10 or pure MeCN (acetonitrile)Analytical ColumnsAcclaim Trinity P2,3μm,Analytical column, 3.0 x 50mm085433Acclaim Trinity P2,3μm,Analytical column, 3.0 x 100mm085434Acclaim Trinity P2,3μm,Analytical column, 2.1 x 50mm085431Acclaim Trinity P2,3μm, Analytical column, 2.1 x 100mm085432Guard ColumnsAcclaim Trinity P2,3μm,Guard column, 3.0 x 10mm, 2/pk requires holder 069580085436Acclaim Trinity P2,3μm,Guard column, 2.1 x 10mm, 2/pk requires holder 069580085435Acclaim SST Guard Cartridge Holder V-2069580Acclaim Guard Kit (Holder and coupler) V-2069707Guard to Analytical Column Coupler V-2074188

Acclaim Trinity P2 LC ColumnThe Thermo Scientific™ Acclaim™ Trinity™ P2 column is a high-performance, silica-based column specifically designed for separation of pharmaceutical mono- and multi-valent counterions by high-performance liquid chromatography (HPLC). This column was engineered for analytical chemists who need simple, robust, fast, generic methods. The Acclaim Trinity P2 columns provide an effective solution for counterion analysis using one column and one method on a standard HPLC instrument.? Desired selectivity for pharmaceutical mono- and multi-valent counterion screening? Retention of ionic and ionizable analytes without using ion-pairing reagents? Compatibility with charged aerosol and mass spectrometry detection methods? Easy to use? Rugged packingThe Acclaim Trinity P2 column is based on nanopolymer silica hybrid (NSH) technology. It consists of high-purity, porous, 3 μm particles coated with charged nanopolymer particles: the innerpore area of the silica particles is modified with a covalently bonded hydrophilic layer that provides cation exchange retention, while the outer surface is modified with anion-exchange nanopolymer beads. This chemistry design ensures spatial separation of the anion exchange and cation exchange regions. In addition, its hydrophilic surface makes it useful as a hydrophilic interaction liquid chromatography (HILIC) column. Thus, the Acclaim Trinity P2 column provides cation-exchange, anion-exchange, and HILIC retentions on the same stationary phase.NSH Chromatographic FeaturesMultiple retention mechanisms including HILIC, anion-exchange, and cation-exchangeAdjustable selectivity by mobile phase ionic strength, electrolyte type, pH, and organic solventIdeal selectivity for simultaneous separation of basic, neutral, and acidic analytesSeparation of hydrophilic ionic and ionizable analytes without ion-pairing reagentsAcclaim Trinity P2 Column – Superior Performance for Pharmaceutical Applications SpecificationsColumn chemistrySAX, WCX and HILIC Mixed-ModeOperating pressure limit6000 psiOperating pH range2.0 – 8.0Operating flow rate range0.3 – 0.90 mL/min for 3.0-mm i.d. formats0.15 – 0.45 mL/min for 2.1-mm i.d. formatsOrganic compatibilityCompatible with most common HPLC organic solvents except for alcohols.Aqueous compatibility0-100% aqueous mobile phaseStorage solutionMeCN/10mM NH4OAc, pH5 v/v 90/10 or pure MeCN (acetonitrile)Analytical ColumnsAcclaim Trinity P2,3μm,Analytical column, 3.0 x 50mm085433Acclaim Trinity P2,3μm,Analytical column, 3.0 x 100mm085434Acclaim Trinity P2,3μm,Analytical column, 2.1 x 50mm085431Acclaim Trinity P2,3μm, Analytical column, 2.1 x 100mm085432Guard ColumnsAcclaim Trinity P2,3μm,Guard column, 3.0 x 10mm, 2/pk requires holder 069580085436Acclaim Trinity P2,3μm,Guard column, 2.1 x 10mm, 2/pk requires holder 069580085435Acclaim SST Guard Cartridge Holder V-2069580Acclaim Guard Kit (Holder and coupler) V-2069707Guard to Analytical Column Coupler V-2074188

Acclaim Trinity P2 LC ColumnThe Thermo Scientific™ Acclaim™ Trinity™ P2 column is a high-performance, silica-based column specifically designed for separation of pharmaceutical mono- and multi-valent counterions by high-performance liquid chromatography (HPLC). This column was engineered for analytical chemists who need simple, robust, fast, generic methods. The Acclaim Trinity P2 columns provide an effective solution for counterion analysis using one column and one method on a standard HPLC instrument.? Desired selectivity for pharmaceutical mono- and multi-valent counterion screening? Retention of ionic and ionizable analytes without using ion-pairing reagents? Compatibility with charged aerosol and mass spectrometry detection methods? Easy to use? Rugged packingThe Acclaim Trinity P2 column is based on nanopolymer silica hybrid (NSH) technology. It consists of high-purity, porous, 3 μm particles coated with charged nanopolymer particles: the innerpore area of the silica particles is modified with a covalently bonded hydrophilic layer that provides cation exchange retention, while the outer surface is modified with anion-exchange nanopolymer beads. This chemistry design ensures spatial separation of the anion exchange and cation exchange regions. In addition, its hydrophilic surface makes it useful as a hydrophilic interaction liquid chromatography (HILIC) column. Thus, the Acclaim Trinity P2 column provides cation-exchange, anion-exchange, and HILIC retentions on the same stationary phase.NSH Chromatographic FeaturesMultiple retention mechanisms including HILIC, anion-exchange, and cation-exchangeAdjustable selectivity by mobile phase ionic strength, electrolyte type, pH, and organic solventIdeal selectivity for simultaneous separation of basic, neutral, and acidic analytesSeparation of hydrophilic ionic and ionizable analytes without ion-pairing reagentsAcclaim Trinity P2 Column – Superior Performance for Pharmaceutical Applications SpecificationsColumn chemistrySAX, WCX and HILIC Mixed-ModeOperating pressure limit6000 psiOperating pH range2.0 – 8.0Operating flow rate range0.3 – 0.90 mL/min for 3.0-mm i.d. formats0.15 – 0.45 mL/min for 2.1-mm i.d. formatsOrganic compatibilityCompatible with most common HPLC organic solvents except for alcohols.Aqueous compatibility0-100% aqueous mobile phaseStorage solutionMeCN/10mM NH4OAc, pH5 v/v 90/10 or pure MeCN (acetonitrile)Analytical ColumnsAcclaim Trinity P2,3μm,Analytical column, 3.0 x 50mm085433Acclaim Trinity P2,3μm,Analytical column, 3.0 x 100mm085434Acclaim Trinity P2,3μm,Analytical column, 2.1 x 50mm085431Acclaim Trinity P2,3μm, Analytical column, 2.1 x 100mm085432Guard ColumnsAcclaim Trinity P2,3μm,Guard column, 3.0 x 10mm, 2/pk requires holder 069580085436Acclaim Trinity P2,3μm,Guard column, 2.1 x 10mm, 2/pk requires holder 069580085435Acclaim SST Guard Cartridge Holder V-2069580Acclaim Guard Kit (Holder and coupler) V-2069707Guard to Analytical Column Coupler V-2074188

Acclaim Trinity P2 LC ColumnThe Thermo Scientific™ Acclaim™ Trinity™ P2 column is a high-performance, silica-based column specifically designed for separation of pharmaceutical mono- and multi-valent counterions by high-performance liquid chromatography (HPLC). This column was engineered for analytical chemists who need simple, robust, fast, generic methods. The Acclaim Trinity P2 columns provide an effective solution for counterion analysis using one column and one method on a standard HPLC instrument.? Desired selectivity for pharmaceutical mono- and multi-valent counterion screening? Retention of ionic and ionizable analytes without using ion-pairing reagents? Compatibility with charged aerosol and mass spectrometry detection methods? Easy to use? Rugged packingThe Acclaim Trinity P2 column is based on nanopolymer silica hybrid (NSH) technology. It consists of high-purity, porous, 3 μm particles coated with charged nanopolymer particles: the innerpore area of the silica particles is modified with a covalently bonded hydrophilic layer that provides cation exchange retention, while the outer surface is modified with anion-exchange nanopolymer beads. This chemistry design ensures spatial separation of the anion exchange and cation exchange regions. In addition, its hydrophilic surface makes it useful as a hydrophilic interaction liquid chromatography (HILIC) column. Thus, the Acclaim Trinity P2 column provides cation-exchange, anion-exchange, and HILIC retentions on the same stationary phase.NSH Chromatographic FeaturesMultiple retention mechanisms including HILIC, anion-exchange, and cation-exchangeAdjustable selectivity by mobile phase ionic strength, electrolyte type, pH, and organic solventIdeal selectivity for simultaneous separation of basic, neutral, and acidic analytesSeparation of hydrophilic ionic and ionizable analytes without ion-pairing reagentsAcclaim Trinity P2 Column – Superior Performance for Pharmaceutical Applications SpecificationsColumn chemistrySAX, WCX and HILIC Mixed-ModeOperating pressure limit6000 psiOperating pH range2.0 – 8.0Operating flow rate range0.3 – 0.90 mL/min for 3.0-mm i.d. formats0.15 – 0.45 mL/min for 2.1-mm i.d. formatsOrganic compatibilityCompatible with most common HPLC organic solvents except for alcohols.Aqueous compatibility0-100% aqueous mobile phaseStorage solutionMeCN/10mM NH4OAc, pH5 v/v 90/10 or pure MeCN (acetonitrile)Analytical ColumnsAcclaim Trinity P2,3μm,Analytical column, 3.0 x 50mm085433Acclaim Trinity P2,3μm,Analytical column, 3.0 x 100mm085434Acclaim Trinity P2,3μm,Analytical column, 2.1 x 50mm085431Acclaim Trinity P2,3μm, Analytical column, 2.1 x 100mm085432Guard ColumnsAcclaim Trinity P2,3μm,Guard column, 3.0 x 10mm, 2/pk requires holder 069580085436Acclaim Trinity P2,3μm,Guard column, 2.1 x 10mm, 2/pk requires holder 069580085435Acclaim SST Guard Cartridge Holder V-2069580Acclaim Guard Kit (Holder and coupler) V-2069707Guard to Analytical Column Coupler V-2074188

Acclaim Trinity P2 LC ColumnThe Thermo Scientific™ Acclaim™ Trinity™ P2 column is a high-performance, silica-based column specifically designed for separation of pharmaceutical mono- and multi-valent counterions by high-performance liquid chromatography (HPLC). This column was engineered for analytical chemists who need simple, robust, fast, generic methods. The Acclaim Trinity P2 columns provide an effective solution for counterion analysis using one column and one method on a standard HPLC instrument.? Desired selectivity for pharmaceutical mono- and multi-valent counterion screening? Retention of ionic and ionizable analytes without using ion-pairing reagents? Compatibility with charged aerosol and mass spectrometry detection methods? Easy to use? Rugged packingThe Acclaim Trinity P2 column is based on nanopolymer silica hybrid (NSH) technology. It consists of high-purity, porous, 3 μm particles coated with charged nanopolymer particles: the innerpore area of the silica particles is modified with a covalently bonded hydrophilic layer that provides cation exchange retention, while the outer surface is modified with anion-exchange nanopolymer beads. This chemistry design ensures spatial separation of the anion exchange and cation exchange regions. In addition, its hydrophilic surface makes it useful as a hydrophilic interaction liquid chromatography (HILIC) column. Thus, the Acclaim Trinity P2 column provides cation-exchange, anion-exchange, and HILIC retentions on the same stationary phase.NSH Chromatographic FeaturesMultiple retention mechanisms including HILIC, anion-exchange, and cation-exchangeAdjustable selectivity by mobile phase ionic strength, electrolyte type, pH, and organic solventIdeal selectivity for simultaneous separation of basic, neutral, and acidic analytesSeparation of hydrophilic ionic and ionizable analytes without ion-pairing reagentsAcclaim Trinity P2 Column – Superior Performance for Pharmaceutical Applications SpecificationsColumn chemistrySAX, WCX and HILIC Mixed-ModeOperating pressure limit6000 psiOperating pH range2.0 – 8.0Operating flow rate range0.3 – 0.90 mL/min for 3.0-mm i.d. formats0.15 – 0.45 mL/min for 2.1-mm i.d. formatsOrganic compatibilityCompatible with most common HPLC organic solvents except for alcohols.Aqueous compatibility0-100% aqueous mobile phaseStorage solutionMeCN/10mM NH4OAc, pH5 v/v 90/10 or pure MeCN (acetonitrile)Analytical ColumnsAcclaim Trinity P2,3μm,Analytical column, 3.0 x 50mm085433Acclaim Trinity P2,3μm,Analytical column, 3.0 x 100mm085434Acclaim Trinity P2,3μm,Analytical column, 2.1 x 50mm085431Acclaim Trinity P2,3μm, Analytical column, 2.1 x 100mm085432Guard ColumnsAcclaim Trinity P2,3μm,Guard column, 3.0 x 10mm, 2/pk requires holder 069580085436Acclaim Trinity P2,3μm,Guard column, 2.1 x 10mm, 2/pk requires holder 069580085435Acclaim SST Guard Cartridge Holder V-2069580Acclaim Guard Kit (Holder and coupler) V-2069707Guard to Analytical Column Coupler V-2074188

Acclaim Trinity P2 LC ColumnThe Thermo Scientific™ Acclaim™ Trinity™ P2 column is a high-performance, silica-based column specifically designed for separation of pharmaceutical mono- and multi-valent counterions by high-performance liquid chromatography (HPLC). This column was engineered for analytical chemists who need simple, robust, fast, generic methods. The Acclaim Trinity P2 columns provide an effective solution for counterion analysis using one column and one method on a standard HPLC instrument.? Desired selectivity for pharmaceutical mono- and multi-valent counterion screening? Retention of ionic and ionizable analytes without using ion-pairing reagents? Compatibility with charged aerosol and mass spectrometry detection methods? Easy to use? Rugged packingThe Acclaim Trinity P2 column is based on nanopolymer silica hybrid (NSH) technology. It consists of high-purity, porous, 3 μm particles coated with charged nanopolymer particles: the innerpore area of the silica particles is modified with a covalently bonded hydrophilic layer that provides cation exchange retention, while the outer surface is modified with anion-exchange nanopolymer beads. This chemistry design ensures spatial separation of the anion exchange and cation exchange regions. In addition, its hydrophilic surface makes it useful as a hydrophilic interaction liquid chromatography (HILIC) column. Thus, the Acclaim Trinity P2 column provides cation-exchange, anion-exchange, and HILIC retentions on the same stationary phase.NSH Chromatographic FeaturesMultiple retention mechanisms including HILIC, anion-exchange, and cation-exchangeAdjustable selectivity by mobile phase ionic strength, electrolyte type, pH, and organic solventIdeal selectivity for simultaneous separation of basic, neutral, and acidic analytesSeparation of hydrophilic ionic and ionizable analytes without ion-pairing reagentsAcclaim Trinity P2 Column – Superior Performance for Pharmaceutical Applications SpecificationsColumn chemistrySAX, WCX and HILIC Mixed-ModeOperating pressure limit6000 psiOperating pH range2.0 – 8.0Operating flow rate range0.3 – 0.90 mL/min for 3.0-mm i.d. formats0.15 – 0.45 mL/min for 2.1-mm i.d. formatsOrganic compatibilityCompatible with most common HPLC organic solvents except for alcohols.Aqueous compatibility0-100% aqueous mobile phaseStorage solutionMeCN/10mM NH4OAc, pH5 v/v 90/10 or pure MeCN (acetonitrile)Analytical ColumnsAcclaim Trinity P2,3μm,Analytical column, 3.0 x 50mm085433Acclaim Trinity P2,3μm,Analytical column, 3.0 x 100mm085434Acclaim Trinity P2,3μm,Analytical column, 2.1 x 50mm085431Acclaim Trinity P2,3μm, Analytical column, 2.1 x 100mm085432Guard ColumnsAcclaim Trinity P2,3μm,Guard column, 3.0 x 10mm, 2/pk requires holder 069580085436Acclaim Trinity P2,3μm,Guard column, 2.1 x 10mm, 2/pk requires holder 069580085435Acclaim SST Guard Cartridge Holder V-2069580Acclaim Guard Kit (Holder and coupler) V-2069707Guard to Analytical Column Coupler V-2074188

Acclaim Trinity P2最新的混合模式色谱柱技术，具有亲水相互作用、HILIC、阴离子交换和阳离子交换功能 分离药物对离子，包括单价和二价阴离子和阳离子 选择性与 Trinity P1 色谱柱互补 低柱流失，与 CAD 和 MS 兼容 水解稳定 高柱效Acclaim Trinity P2 是独特的、高柱效、硅胶基质的色谱柱，是专用于药物对离子(包括单价和二价阴离子和阳离子)分析的色谱柱。Acclaim Trinity P2 色谱柱基于 NSH 技术, 由包有带电荷纳米高分子微球的高纯多孔球形 3μm 硅胶颗粒组成。硅胶孔内的键合相具有阳离子交换作用，而外部微孔则具有阴离子交换功能。这种键合相具有阴离子交换和阳离子交换功能。Acclaim Trinity P2 色谱柱与 Acclaim Trinity P1 互补，可在 HPLC 上完成药物对离子的分离。订货信息：

Acclaim Trinity P1混合模式色谱柱技术中最具创新的一大进步：单一填料具备反相、阴离子和阳离子交换功能 是同时分离 API 和对离子的理想选择 可通过流动相离子强度、电解质类型、pH 以及有机溶剂调节选择性 低流失，兼容 MS, CAD 和 ELSD 无需离子对试剂也可保留离子和可离子化的分析物 为方法开发提供更大灵活性：可单独控制每种保留机制Thermo Scientific? Acclaim? Trinity? P1 HPLC 色谱柱采用独特的多模式表面化学键合相，非常适合同时分离药物及其对离子。表面化学键合相同时提供反相、阳离子交换和阴离子交换功能。这为方法开发提供了极大的灵活性。可通过调节色谱参数(流动相pH、离子强度和有机强度)来优化分离。Acclaim Trinity P1 固定相采用纳米杂化硅聚合物 (NSH) 技术，由包有带电荷纳米高分子微球的高纯多孔球形 3μm 硅胶颗粒组成。硅胶孔内的键合相同时具有反相和阴离子交换特性，而硅胶外部的微球具有阳离子交换功能。订货信息：

Acclaim Trinity P1混合模式色谱柱技术中最具创新的一大进步：单一填料具备反相、阴离子和阳离子交换功能 是同时分离 API 和对离子的理想选择 可通过流动相离子强度、电解质类型、pH 以及有机溶剂调节选择性 低流失，兼容 MS, CAD 和 ELSD 无需离子对试剂也可保留离子和可离子化的分析物 为方法开发提供更大灵活性：可单独控制每种保留机制Thermo Scientific? Acclaim? Trinity? P1 HPLC 色谱柱采用独特的多模式表面化学键合相，非常适合同时分离药物及其对离子。表面化学键合相同时提供反相、阳离子交换和阴离子交换功能。这为方法开发提供了极大的灵活性。可通过调节色谱参数(流动相pH、离子强度和有机强度)来优化分离。Acclaim Trinity P1 固定相采用纳米杂化硅聚合物 (NSH) 技术，由包有带电荷纳米高分子微球的高纯多孔球形 3μm 硅胶颗粒组成。硅胶孔内的键合相同时具有反相和阴离子交换特性，而硅胶外部的微球具有阳离子交换功能。订货信息：

Acclaim Trinity P2最新的混合模式色谱柱技术，具有亲水相互作用、HILIC、阴离子交换和阳离子交换功能 分离药物对离子，包括单价和二价阴离子和阳离子 选择性与 Trinity P1 色谱柱互补 低柱流失，与 CAD 和 MS 兼容 水解稳定 高柱效Acclaim Trinity P2 是独特的、高柱效、硅胶基质的色谱柱，是专用于药物对离子(包括单价和二价阴离子和阳离子)分析的色谱柱。Acclaim Trinity P2 色谱柱基于 NSH 技术, 由包有带电荷纳米高分子微球的高纯多孔球形 3μm 硅胶颗粒组成。硅胶孔内的键合相具有阳离子交换作用，而外部微孔则具有阴离子交换功能。这种键合相具有阴离子交换和阳离子交换功能。Acclaim Trinity P2 色谱柱与 Acclaim Trinity P1 互补，可在 HPLC 上完成药物对离子的分离。订货信息：

Acclaim Trinity P2最新的混合模式色谱柱技术，具有亲水相互作用、HILIC、阴离子交换和阳离子交换功能 分离药物对离子，包括单价和二价阴离子和阳离子 选择性与 Trinity P1 色谱柱互补 低柱流失，与 CAD 和 MS 兼容 水解稳定 高柱效Acclaim Trinity P2 是独特的、高柱效、硅胶基质的色谱柱，是专用于药物对离子(包括单价和二价阴离子和阳离子)分析的色谱柱。Acclaim Trinity P2 色谱柱基于 NSH 技术, 由包有带电荷纳米高分子微球的高纯多孔球形 3μm 硅胶颗粒组成。硅胶孔内的键合相具有阳离子交换作用，而外部微孔则具有阴离子交换功能。这种键合相具有阴离子交换和阳离子交换功能。Acclaim Trinity P2 色谱柱与 Acclaim Trinity P1 互补，可在 HPLC 上完成药物对离子的分离。订货信息：

Acclaim Trinity P2最新的混合模式色谱柱技术，具有亲水相互作用、HILIC、阴离子交换和阳离子交换功能 分离药物对离子，包括单价和二价阴离子和阳离子 选择性与 Trinity P1 色谱柱互补 低柱流失，与 CAD 和 MS 兼容 水解稳定 高柱效Acclaim Trinity P2 是独特的、高柱效、硅胶基质的色谱柱，是专用于药物对离子(包括单价和二价阴离子和阳离子)分析的色谱柱。Acclaim Trinity P2 色谱柱基于 NSH 技术, 由包有带电荷纳米高分子微球的高纯多孔球形 3μm 硅胶颗粒组成。硅胶孔内的键合相具有阳离子交换作用，而外部微孔则具有阴离子交换功能。这种键合相具有阴离子交换和阳离子交换功能。Acclaim Trinity P2 色谱柱与 Acclaim Trinity P1 互补，可在 HPLC 上完成药物对离子的分离。订货信息：

Acclaim Trinity P2最新的混合模式色谱柱技术，具有亲水相互作用、HILIC、阴离子交换和阳离子交换功能 分离药物对离子，包括单价和二价阴离子和阳离子 选择性与 Trinity P1 色谱柱互补 低柱流失，与 CAD 和 MS 兼容 水解稳定 高柱效Acclaim Trinity P2 是独特的、高柱效、硅胶基质的色谱柱，是专用于药物对离子(包括单价和二价阴离子和阳离子)分析的色谱柱。Acclaim Trinity P2 色谱柱基于 NSH 技术, 由包有带电荷纳米高分子微球的高纯多孔球形 3μm 硅胶颗粒组成。硅胶孔内的键合相具有阳离子交换作用，而外部微孔则具有阴离子交换功能。这种键合相具有阴离子交换和阳离子交换功能。Acclaim Trinity P2 色谱柱与 Acclaim Trinity P1 互补，可在 HPLC 上完成药物对离子的分离。订货信息：

Acclaim Trinity P1混合模式色谱柱技术中最具创新的一大进步：单一填料具备反相、阴离子和阳离子交换功能 是同时分离 API 和对离子的理想选择 可通过流动相离子强度、电解质类型、pH 以及有机溶剂调节选择性 低流失，兼容 MS, CAD 和 ELSD 无需离子对试剂也可保留离子和可离子化的分析物 为方法开发提供更大灵活性：可单独控制每种保留机制Thermo Scientific? Acclaim? Trinity? P1 HPLC 色谱柱采用独特的多模式表面化学键合相，非常适合同时分离药物及其对离子。表面化学键合相同时提供反相、阳离子交换和阴离子交换功能。这为方法开发提供了极大的灵活性。可通过调节色谱参数(流动相pH、离子强度和有机强度)来优化分离。Acclaim Trinity P1 固定相采用纳米杂化硅聚合物 (NSH) 技术，由包有带电荷纳米高分子微球的高纯多孔球形 3μm 硅胶颗粒组成。硅胶孔内的键合相同时具有反相和阴离子交换特性，而硅胶外部的微球具有阳离子交换功能。订货信息：

Acclaim Trinity P1 SeriesAcclaim Trinity P1 is a unique, high-efficiency, silica-based column designed for pharmaceutical applications such as simultaneous separation of pharmaceutical drug substances and their counterions. This new column, based on nanopolymer silica hybrid (NSH) technology, provides multiple retention mechanisms including reversed-phase, anion-exchange, and cation-exchange. As a result, its selectivity can be easily optimized by adjusting mobile phase buffer concentration, pH, and solvent content concurrently or independently. The NSH technology ensures distinctive spatial separation of the anion-exchange and cation-exchange regions, which results in maximum flexibility in method development. The easy-to-optimize selectivity can be used to accelerate chromatographic separations and increase productivity.NSH Chromatographic Features Multiple retention mechanisms including reversed-phase, anion-exchange, and cation-exchangeAdjustable selectivity by mobile phase ionic strength, electrolyte type, pH, and organic solventIdeal selectivity for simultaneous separation of basic, neutral, and acidic analytesSeparation of hydrophilic ionic and ionizable analytes without ion-pairing reagentsAcclaim Trinity P1 ApplicationsActive pharmaceutical ingredients (API) and counterions (cations or anions)Screening of pharmaceutical counterions. Both UV and evaporative light scattering (ELS) detectors, in series, are required for simultaneous determination of both drug substances and counterions.Mixture of acidic and basic drug substances and respective counterionsDrug substances of acidic, basic, and neutral mixturesHigh throughput analysis following optimization of the selectivity and resolution. The flow rate can then be increased, and the analysis time shortened.Acclaim Trinity P1 Column – Superior Performance for Pharmaceutical Applications SpecificationsColumn chemistrySCX, WAX and RP Mixed-ModeOperating pressure limit (recommended)4500 psi (4000 psi)Operating pH range (recommended)2.5 – 7.0 (3.0 to 6.2)Operating flow rate range (recommended)0.3 – 1.5(0.4 – 0.8) mL/min for 3.0-mm i.d. formats0.15 – 0.80 (0.2 to 0.4) mL/min for 2.1-mm i.d. formatsAnalytical ColumnsAcclaim Trinity P1, 3μm, 3.0 x 150mm075563Acclaim Trinity P1, 3μm Analytical, (3.0 x 100mm)071387Acclaim Trinity P1, 3μm Analytical, (3.0 x 50mm)071388Acclaim Trinity P1, 3μm, 2.1 x 150mm075564Acclaim Trinity P1, 3μm Analytical, (2.1 x 100mm)071389Acclaim Trinity P1, 3μm, 2.1 x 50mm075565Guard ColumnsAcclaim Trinity P1, 3μm Guard Cartridges, (3.0 x 10mm), 2ea (Use Holder V-2)071390Acclaim Trinity P1, 3μm Guard Cartridges, (2.1 x 10mm), 2ea (Use Holder V-2)071391Acclaim SST Guard Cartridge Holder V-2069580Acclaim Guard Kit (Holder and coupler) V-2069707Guard to Analytical Column Coupler V-2074188

Acclaim Trinity P1 SeriesAcclaim Trinity P1 is a unique, high-efficiency, silica-based column designed for pharmaceutical applications such as simultaneous separation of pharmaceutical drug substances and their counterions. This new column, based on nanopolymer silica hybrid (NSH) technology, provides multiple retention mechanisms including reversed-phase, anion-exchange, and cation-exchange. As a result, its selectivity can be easily optimized by adjusting mobile phase buffer concentration, pH, and solvent content concurrently or independently. The NSH technology ensures distinctive spatial separation of the anion-exchange and cation-exchange regions, which results in maximum flexibility in method development. The easy-to-optimize selectivity can be used to accelerate chromatographic separations and increase productivity.NSH Chromatographic Features Multiple retention mechanisms including reversed-phase, anion-exchange, and cation-exchangeAdjustable selectivity by mobile phase ionic strength, electrolyte type, pH, and organic solventIdeal selectivity for simultaneous separation of basic, neutral, and acidic analytesSeparation of hydrophilic ionic and ionizable analytes without ion-pairing reagentsAcclaim Trinity P1 ApplicationsActive pharmaceutical ingredients (API) and counterions (cations or anions)Screening of pharmaceutical counterions. Both UV and evaporative light scattering (ELS) detectors, in series, are required for simultaneous determination of both drug substances and counterions.Mixture of acidic and basic drug substances and respective counterionsDrug substances of acidic, basic, and neutral mixturesHigh throughput analysis following optimization of the selectivity and resolution. The flow rate can then be increased, and the analysis time shortened.Acclaim Trinity P1 Column – Superior Performance for Pharmaceutical Applications SpecificationsColumn chemistrySCX, WAX and RP Mixed-ModeOperating pressure limit (recommended)4500 psi (4000 psi)Operating pH range (recommended)2.5 – 7.0 (3.0 to 6.2)Operating flow rate range (recommended)0.3 – 1.5(0.4 – 0.8) mL/min for 3.0-mm i.d. formats0.15 – 0.80 (0.2 to 0.4) mL/min for 2.1-mm i.d. formatsAnalytical ColumnsAcclaim Trinity P1, 3μm, 3.0 x 150mm075563Acclaim Trinity P1, 3μm Analytical, (3.0 x 100mm)071387Acclaim Trinity P1, 3μm Analytical, (3.0 x 50mm)071388Acclaim Trinity P1, 3μm, 2.1 x 150mm075564Acclaim Trinity P1, 3μm Analytical, (2.1 x 100mm)071389Acclaim Trinity P1, 3μm, 2.1 x 50mm075565Guard ColumnsAcclaim Trinity P1, 3μm Guard Cartridges, (3.0 x 10mm), 2ea (Use Holder V-2)071390Acclaim Trinity P1, 3μm Guard Cartridges, (2.1 x 10mm), 2ea (Use Holder V-2)071391Acclaim SST Guard Cartridge Holder V-2069580Acclaim Guard Kit (Holder and coupler) V-2069707Guard to Analytical Column Coupler V-2074188

Acclaim Trinity P1 SeriesAcclaim Trinity P1 is a unique, high-efficiency, silica-based column designed for pharmaceutical applications such as simultaneous separation of pharmaceutical drug substances and their counterions. This new column, based on nanopolymer silica hybrid (NSH) technology, provides multiple retention mechanisms including reversed-phase, anion-exchange, and cation-exchange. As a result, its selectivity can be easily optimized by adjusting mobile phase buffer concentration, pH, and solvent content concurrently or independently. The NSH technology ensures distinctive spatial separation of the anion-exchange and cation-exchange regions, which results in maximum flexibility in method development. The easy-to-optimize selectivity can be used to accelerate chromatographic separations and increase productivity.NSH Chromatographic Features Multiple retention mechanisms including reversed-phase, anion-exchange, and cation-exchangeAdjustable selectivity by mobile phase ionic strength, electrolyte type, pH, and organic solventIdeal selectivity for simultaneous separation of basic, neutral, and acidic analytesSeparation of hydrophilic ionic and ionizable analytes without ion-pairing reagentsAcclaim Trinity P1 ApplicationsActive pharmaceutical ingredients (API) and counterions (cations or anions)Screening of pharmaceutical counterions. Both UV and evaporative light scattering (ELS) detectors, in series, are required for simultaneous determination of both drug substances and counterions.Mixture of acidic and basic drug substances and respective counterionsDrug substances of acidic, basic, and neutral mixturesHigh throughput analysis following optimization of the selectivity and resolution. The flow rate can then be increased, and the analysis time shortened.Acclaim Trinity P1 Column – Superior Performance for Pharmaceutical Applications SpecificationsColumn chemistrySCX, WAX and RP Mixed-ModeOperating pressure limit (recommended)4500 psi (4000 psi)Operating pH range (recommended)2.5 – 7.0 (3.0 to 6.2)Operating flow rate range (recommended)0.3 – 1.5(0.4 – 0.8) mL/min for 3.0-mm i.d. formats0.15 – 0.80 (0.2 to 0.4) mL/min for 2.1-mm i.d. formatsAnalytical ColumnsAcclaim Trinity P1, 3μm, 3.0 x 150mm075563Acclaim Trinity P1, 3μm Analytical, (3.0 x 100mm)071387Acclaim Trinity P1, 3μm Analytical, (3.0 x 50mm)071388Acclaim Trinity P1, 3μm, 2.1 x 150mm075564Acclaim Trinity P1, 3μm Analytical, (2.1 x 100mm)071389Acclaim Trinity P1, 3μm, 2.1 x 50mm075565Guard ColumnsAcclaim Trinity P1, 3μm Guard Cartridges, (3.0 x 10mm), 2ea (Use Holder V-2)071390Acclaim Trinity P1, 3μm Guard Cartridges, (2.1 x 10mm), 2ea (Use Holder V-2)071391Acclaim SST Guard Cartridge Holder V-2069580Acclaim Guard Kit (Holder and coupler) V-2069707Guard to Analytical Column Coupler V-2074188

Acclaim Trinity Q1用于敌草快和百草枯的痕量分离 对敌草快和百草枯具有很高的分离度 峰形良好 快速分析 LC/MS 兼容性 不需要离子对试剂 易用Acclaim Trinity Q1 色谱柱是独特、高效的硅胶基质色谱柱，专为敌草快和百草枯的分离而设计。这两种农药是剧毒化合物，在饮用水、废水和农产品中，都需要监测其含量。Acclaim Trinity Q1色谱柱是三模式 (WCX, WAX, RP) 色谱柱，基于 CSH 技术。可以使用 LC-MS/MS 和 LC-UV 方法对敌草快和百草枯实现高通量的痕量分析。订货信息：