台式聚焦超声系统采用超声波原理,具有安全性,可靠性,灵活性,高效性。特点:安全性:因为超声波可以应用于临床,所以仪器采用超声波原理转染,可以保证后期临床试验研究的安全性。灵活性:超声波转染仪的传感器模块具有自我校正功能,此模块可以更换。可用于聚焦超声研究(FUS):具有高强度聚焦超声传感器模块。可以结合微泡使用:仪器结合微泡(Microbubbles)使用,可以提高转染效率 并且使用特殊的微泡(如Targesphere SA)可以靶向特定细胞。技术特征1、输出频率输出频率固定在1 MHz和3MHz,以优化和可重复地穿透组织培养容器和基于组织的目标。2、超声功率/密度选项超声功率密度/强度选项在0和5 W / cm 2之间 ,以0.1 W / cm2调节。3、占空比范围各种占空比范围为5 - 100%,增量为5%,脉冲频率为100 Hz。4、自动化治疗控制时间自动控制治疗时间,可在数秒内调整至90秒的治疗时间,此后在数分钟内直至治疗时间为60分钟。5、水封超声头超声波头是水密封的,并且与液体中的操作浸没兼容。6、预编程的治疗参数提供10个操作程序,其中5个预先编程为适当的治疗参数,以通过SONIDEL STK实现优化的超声介导转染,配备对照转染试剂盒。其他5个程序可以根据操作员选择的特定条件进行调整7、超声剂量反馈控制超声头配备有反馈控制,如果与目标接触并且超声波传输到目标,则自动关闭计时器。在这种情况下,定时器机制将在接触受损的准确时间停止并发出声音警报。8、可定制的功能可能会提供自定义功能代表论文:Gemcitabine loaded microbubbles for targeted chemo-sonodynamic therapy of pancreatic cancerNesbitt H, Sheng Y, Kamila S, Logan K, Thomas K, Callan B, Taylor MA, Love M, O' Rourke D, Kelly P, Beguin E, Stride E, McHale AP, Callan JFJournal of Controlled Release, Volume 279, 10 June 2018, Pages 8-16Pro-apoptotic liposomes-nanobubble conjugate synergistic with paclitaxel: a platform for ultrasound responsive image-guided drug deliveryRajeet Chandan & Rinti BanerjeeNature: Scientific Reports, Published: 08 February 2018Antimicrobial sonodynamic and photodynamic therapies against Candida albicansFernanda Alves, Ana Cláudia Pavarina ORCID Icon, Ewerton Garcia de Oliveira Mima, Anthony P. McHale & John Francis CallanThe Journal of Bioadhesion and Biofilm Research, 06 Feb 2018, Published online: 19 Apr 2018, Pages 357-367Human Concentrative Nucleoside Transporter 3 Transfection with Ultrasound and Microbubbles in Nucleoside Transport Deficient HEK293 Cells Greatly Increases Gemcitabine UptakeRobert J. Paproski, Sylvia Y. M. Yao, Nicole Favis, David Evans, James D. Young, Carol E. Cass, Roger J. ZempPLoS ONEPublished: February 18, 2013A versatile, stimulus-responsive nanoparticle-based platform for use in both sonodynamic and photodynamic cancer therapyNomikou N, Curtis K, McEwan C, O' Hagan BM, Callan B, Callan JF, McHale AP.Acta Biomater. 2017 Feb 49:414-421. doi: 10.1016/j.actbio.2016.11.031. Epub 2016 Nov 14.Magnetically responsive microbubbles as delivery vehicles for targeted sonodynamic and antimetabolite therapy of pancreatic cancerYingjie Shenga, Estelle Beguinb, Heather Nesbitt, Sukanta Kamila, Joshua Owen, Lester C. Barnsley, Bridgeen Callan, Christopher O' Kane, Nikolitsa Nomikou, Rifat Hamoudi, Mark A.Taylor, Mark Love, Paul Kelly, Declan O' Rourke, Eleanor Stride, Anthony P. McHale, John F.CallanJournal of Controlled Release, Volume 262, 28 September 2017, Pages 192-200Ultrasound-responsive gene-activated matrices for osteogenic gene therapy using matrix-assisted sonoporationNomikou N, Feichtinger GA, Saha S, Nuernberger S, Heimel P, Redl H, McHale AP.J Tissue Eng Regen Med. 2017 Jan 13. doi: 10.1002/term.2406. [Epub ahead of print]Development of a novel microbubble-liposome complex conjugated with peptide ligands targeting IL4R on brain tumor cellsPark SH, Yoon YI, Moon H, Lee GH, Lee BH, Yoon TJ, Lee HJOncol Rep. 2016 Jul 36(1):131-6. doi: 10.3892/or.2016.4836. Epub 2016 May 24.
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