拉克塔利斯

In this work multimodal operation of commercially available CARSmicrospectrometer (EKSPLA CARSCOPE) equipped with a picoseconddual wavelength laser source (EKSPLA PT259) was demonstrated forthe imaging of various biological objects using coherent anti‑ StokesRaman scattering (CARS), two photon excited fluorescence (TPEF)and second harmonic generation (SHG) contrast mechanisms.Obtained CARS‑ images of yeast cell and flower pollen clearlydemonstrate label‑ free and 3D imaging capabilities of CARS technique.Multi‑ contrast images of green algae and plants containing starchdemonstrate a variety of research facilities, where the method can beapplied.

LaVision公司的DaVis软件平台，加载抖盒子（Shake-The-Box）拉格朗日视角粒子轨迹追踪算法，可以获得高密度示踪粒子条件下的拉格朗日粒子轨迹集合，并由此获得流体的时间分辨3D3C速度矢量场和加速度场。

Amphetamines are controlled substances whichare potent stimulants that induce feelings ofstrength and energy while decreasing the need tosleep or eat. The majority of illegal amphetamineproducts are racemic consequently, both isomerswill appear in the biological fluids unchanged. Incomparison the break-down products formed bythe metabolism of most pharmaceutical drugsshow the appearance of pure amphetamineenantiomers. Circular dichroism is a form of lightabsorption spectroscopy that measures thedifference in absorbance of right- and leftcircularlypolarized light (rather than the commonlyused absorbance of isotropic light) by a substance.Since different enantiomers absorb differentportions of the light, it provides and excellentmeans for enantiomer detection. In thisapplication CD will be used to study the isomers ofamphetamine and methamphetamine.

The new DataPhysics lamella method was introduced, which permits the rapid and easy determination of the surface tension of liquids at temperatures up to 400℃. With the example of a high viscous hotmelt adhesive, an accuracy of the method of 1﹪was achieved.

Metal–organic frameworks assembled from flexible alicyclic carboxylate and bipyridyl ligands for sensing of nitroaromatic explosives

The new DataPhysics lamella method was introduced, which permits the rapid and easy determination of the surface tension of liquids at temperatures up to 400℃. With the example of a high viscous hotmelt adhesive, an accuracy of the method of 1﹪was achieved.

An RSLC-MS/MS method for quantitative analysis of five ethanolamines was developed and described. By using a mixed-mode analytical column and selective MRM MS/MS detection, this method showed significant improvements over previously reported methods with minimum sample preparation, totalchromatographic resolution, capability of sub-ppb level quantification, and high throughput. Application of this method to the analysis of surface waters was demonstrated and showed no quantifiable amounts above the LRLs. Matrix effects and recovery were evaluated using two surface water matrices and the results indicated better quantitation accuracy for DEA by using an isotope labeled analogue as an internal standard.

本篇应用报告，我们使用丹东百特仪器公司的BeNano 90 Zeta 纳米粒度及Zeta电位分析仪检测了分散在水性环境中的纳米黑炭黑颗粒的粒径信息和Zeta电位，并得出结论。

本文参照国家药监局化妆品补充检验规定《化妆品中他克莫司和吡美莫司的测定》（BJH202301），建立了使用岛津三重四极杆液质联用仪测定化妆品中他克莫司和吡美莫司的方法。结果表明，在线性范围内，线性相关系数r 0.999，线性良好。基质混合标准溶液重复性保留时间RSD%为0.04~0.26%，峰面积RSD%为0.49%~3.27%。加标回收率为95.6%~115.5%。该方法快速、稳定、准确，可应对化妆品中他克莫司和吡美莫司快速定量分析。

保圣科技TA.XTC质构仪对比法兰克福和口利左香肠的剪切力。TA.XTC型质构仪，具备优良的软件控制及自动分析数据的性能，测试参数全部通过软件输入，软件带有控制键，无需手接触仪器，只需点击鼠标可以进行仪器各种操作，数据分析时不需另外撰写分析程序，用户可直接勾选所要的参数，软件即可自动计算结果，而且测试精度高、位移精准，实验方法丰富，可通过更换探头、夹具、力量感应元等，适合不同的样品测定分析。 该款质构仪特别适用于食品物性学的研究及教学、企业工厂的新产品开发、配方研究、工艺条件探索等。

让看不见的东西变得可见-在这一座右铭下，埃特林根市与来自卡尔斯鲁厄Stadtwerke Ettlingen和Palas GmbH一起开始了一个测量空气质量的试点项目。

在这篇应用报告中，我们通过安东帕Litesizer 500仪器使用DLS和ELS，来确定2 nm-10 nm纳米金颗粒的胶体稳定性。

在本申请说明中，我们使用颗粒分析软件评估了金刚石抛光片中金刚石的分布。关键词：拉曼光谱，QRi，图谱，颗粒分析，金刚石

在这篇研究中，我们用LitesizerTM 500应用动态光散射（DLS）和电泳光散射（ELS）测试硅悬浮液的颗粒度和zeta电位。我们也研究了颗粒度和zeta电位受pH值的影响，以及加入PEG对硅悬浮液的影响。

辣椒颗粒是以辣椒粉直接造粒或经籽皮分离的辣椒果皮经干燥，粉碎，造粒等工序制成的。《T/CFAA 0004-2021 辣椒红原料 辣椒颗粒》中规定用硬度计随机抽取样品10组，求取10组的平均数作为其硬度值，在3.0-4.5kg之间

Full quantitative analysis of eleven trace elements in a solid Cu matrix by Laser Ablation ICP-MS has been demonstrated using commercially available calibration standards and standard reference materials. The high sensitivity of the Thermo Scientific iCAP Q ICP-MS in KED mode, with its proprietary Flatapole technology makes the detection of sub-ppm levels of contaminants in solid Cu easily achievable. The larger ablation two-volume cell of New Wave’s NWR213 Laser system is suited for a high-volume operation allowing a batch analysis of any number of samples that fit inside a 100x100 mm cell space. The seamless interface between the laser and the ICPMS systems allows the analyst the convenience to perform the operation and collect data directly from one computer screen.

Auto-Compensating LII (AC-LII)􀁺 two-color pyrometry to determine theparticle temperature— permits use of low-fluence— particles are kept below the sublimationtemperature􀁺 this new technique automaticallycompensates for any changes in theexperimental conditions— fluctuations in local ambient temperature— variation in laser fluence— laser beam attenuation by the particulatematter— desorption of condensed volatile materialAC-LII Features􀁺 in situ and nonintrusive􀁺 signal is proportional to soot volumefraction􀁺 spatially resolved􀁺 time resolved􀁺 large measurement range— not limited by aggregate size􀁺 high precision and repeatability􀁺 high speed data acquisition and analysisAC-LII Benefits􀁺 dilution of sample not required􀁺 stable measurement of elemental carbon􀁺 insensitive to presence of other species􀁺 can operate at very low concentrations􀁺 real-time results􀁺 cycle-resolved measurements possible􀁺 can provide particulate morphology (size,size distribution, number density) whencombined with scattering

A forensic method for analysis of opiates, opioids, andtheir metabolites without hydrolysis has been developedusing the Prelude SPLC system and TSQ Endura MS. Byeliminating the hydrolysis step, the sample preparationtime and analysis cost was drastically reduced. The LCmethod on the Prelude SPLC system/TSQ Endura MS provided ample resolution for all isobaric compounds andan outstanding increase in overall speed of analysis. The high sensitivity that the TSQ Endura MS provided allowed for low limits of quantitation of even the least responsive analytes, like the gluronidated metabolites. The fast SRMacquisition rate yielded a successful, simultaneous analysisof 19 compounds with 10 internal standards.

使用烤过和未烤过的可可豆生产的巧克力的氧化稳定性和酚类含量Phenolic content and oxidative stability of chocolates produced with roasted and unroasted cocoa beansTotal fat content：总脂肪含量：The total fat content of cocoa beans was determined using the Soxhlet procedure (AOAC, 1995). Fat was extracted with a fully automated extraction system (Gerhardt-Soxtherm, Germany) using petroleum ether as a solvent.可可豆总脂肪含量使用石油醚做为溶剂由格哈特全自动索氏提取系统-索克森Soxtherm提取。

植物会从其环境(土壤、水、空气)中摄取元素，植物中必需元素或有毒元素的分布提供了金属吸收和积累的重要信息。植物结构(根、茎、叶、花)中这些元素的详细空间分析(2D和3D)可用于确定营养元素、必要元素、有毒元素对植物健康的潜在影响，甚至可以了解气候变化和环境污染等条件。在本研究中，我们展示了如何使用Applied Spectra公司的J200 LA-LIBS复合系统在叶片样品的各个位置同时检测39K+、63Cu+、88Sr+、75As+、208Pb+、Ca、Mg、C、H、O。元素分布图显示叶片对Pb和As的吸收方式不同。

使用ICP-MS测量硅（Si）富有挑战性。等离子体中形成的14N2+和12C16O+ 多原子离子，与丰度最高的Si同位素（28Si 92 %丰度）的m/z相同。因此，当多原子离子未被去除时（标准模式下），m/z 28处的背景等效浓度非常高。它抑制了低水平Si的测定，让SiO2纳米颗粒的检测变得更加困难。此外，Si的电离势相对较高，其电离也更具挑战性，导致其强度低于其它易电离的元素，如Na。然而，如果能提高信背比（S/B），就有可能检测到更小的SiO2纳米颗粒。在之前的应用报告中，2我们介绍过100 nm SiO2纳米颗粒标准品可以使用SP-ICP-MS进行分析，且无需去除干扰（标准模式下）。然而，如果能在反应模式下去除干扰，预期能精准测量更小的SiO2纳米颗粒。本工作将讨论在反应模式下，通过SP-ICP-MS检测、测量和表征SiO2纳米颗粒的能力。

本实验采用Gemini C18，（3μm，4.6×150mm）色谱柱与Kinetex Biphenyl（5 μm；4.6×250 mm）串联，对他克莫司及两种杂质进行测试，实验结果表明，两根色谱柱串联后，主成分与两种杂质均实现了良好分离。

在本申请说明中，使用IR和拉曼显微光谱依次分析了喷涂塑料颗粒的样品的成分分布。关键词：拉曼显微镜、红外光谱显微镜、IQ Frame、QRi、图谱、微塑料、蛋白质

保圣科技TA.XTC质构仪通过穿刺试验测试不同品牌巧克力的硬度。TA.XTC型质构仪，具备优良的软件控制及自动分析数据的性能，测试参数全部通过软件输入，软件带有控制键，无需手接触仪器，只需点击鼠标可以进行仪器各种操作，数据分析时不需另外撰写分析程序，用户可直接勾选所要的参数，软件即可自动计算结果，而且测试精度高、位移精准，实验方法丰富，可通过更换探头、夹具、力量感应元等，适合不同的样品测定分析。 该款质构仪特别适用于食品物性学的研究及教学、企业工厂的新产品开发、配方研究、工艺条件探索等。

本研究建立了一种高灵敏度、高特异性的分析方法，用于定量分析一组环孢素 A (CsA)、依维莫司 (Eve)、西罗莫司 (Sir) 以及他克莫司 (Tac)。该方法运行时间为 2 分钟，适于同时定量分析全血中的所有四种分析物。

We present the synthesis of new derivatives of natural products magnolol (1) and honokiol (2) and their evaluation as allosteric ligands for modulation of GABAA receptor activity. New derivatives were prepared via metal assisted cross-coupling reactions in two consecutive steps. Compounds were tested by means of two-electrode voltage clamp electrophysiology at the a1b2c2 receptor subtype at low GABA concentrations.We have identified several compounds enhancing GABA induced current (IGABA) in the range similar or even higher than the lead structures. At 3 lM, compound 8g enhanced IGABA by factor of443, compared to 162 and 338 of honokiol and magnolol, respectively. Furthermore, 8g at EC10–20 featuresa much bigger window of separation between the a1b2c2 and the a1b1c2 subtypes compared to honokiol, and thus improved subtype selectivity.

Pesticide residues remaining in or on commoditiesraise concerns for food safety and environmentalimpact. Regulatory agencies have published policystatements to guide agricultural organizations on theproper use of pesticides and established MaximumResidue Limits (MRLs) of pesticides in various foodmatrices. Thus, there are widely demands for highlysensitive and robust platform for the quantification ofpesticide residues analysis..

使用高灵敏度的LCMS-8050系统，人血浆样品仅需乙腈沉淀蛋白，无需复杂萃取净化过程，即可在6 min内快速、准确地对人血浆中克拉屈滨、克罗拉滨、奈拉滨进行同时测定。

粒细胞集落刺激因子（granulocyte colony-st imulatingfactor，G-CSF)是肿瘤病人化疗后提升白细胞的标准疗法，其中重组人粒细胞集落刺激因子（recombinant human granulocytecolonystimulating factor，rhG-CSF)已经广泛应用于化疗和放疗引起的白细胞数减少症[1]。成熟的内源性人粒细胞集落刺激因子（G-CSF)由174个氨基酸构成，分子量为18-20kDa。 利用基因工程技术，Amgen公司在1991年上市了大肠杆菌发酵的短效版G-CSF非格司亭（Neupogen），2001年上市了长效版G-CSF培非格司亭（Peglgrastim，Neulasta）Neupogen和Neulasta两者的区别在于长效版使用了PEG的修饰技术，使CSF的分子量和体积变大，延长了半衰期，从而把化疗周期内的注射次数从7-10次减少到1次注射，增加了临床使用的便利。

人们已经意识到研究大气雾霾不仅要研究它的危害，还要终落实到控制和预防，这就牵涉到雾霾的核心物质——大气气溶胶。“识别”大气中气溶胶颗粒物的形成机理、污染物组分成为当务之急。那么有哪些方法可以快速“识”雾霾呢？