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The Q Exactive MS is well suited for targeted quantification
providing two powerful HR/AM approaches, msx tSIM and tHCD. Both approaches demonstrate high selectivity, high sensitivity and high throughput due to several hardware
and software innovations.
? For the msx tSIM approach, high mass accuracy (< 5 ppm)
and high resolution (140K) ensures accurate identification
of target ions in the presence of complex background, while
spectrum multiplexing dramatically increases throughput without sacrificing resolution.
? A LOD of 10 amol and 4-order linear dynamic range was obtained for most peptides with msx tSIM method in the presence of medium complex background.
? Different from triple-quadrupole-based SRM, all fragment ions are simultaneously detected with high mass accuracy and high resolution using the tHCD approach. The HR/AM of fragment ions provides unmatched selectivity. The simultaneous detection of all fragment ions allows more efficient sampling of target peptides and results in improved sensitivity. A scan speed of 12 Hz at a resolution of 17,500 ensures high throughput.
? A LOD of 50 amol and 3-4 orders linear dynamic range was obtained for most peptides with tHCD method in the presence of strong complex background.
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赛默飞质谱分析为您提供《蛋白质药物中多种成分分析检测方案(液质联用仪)》，该方案主要用于生物药品中含量测定检测，参考标准《暂无》，《蛋白质药物中多种成分分析检测方案(液质联用仪)》用到的仪器有赛默飞Q Exactive Orbitrap LCMSMS系统、赛默飞TSQ Endura三重四极杆质谱仪、赛默飞TSQ Quantiva 三重四极杆质谱仪、赛默飞Q Exactive Focus LCMSMS 系统、赛默飞LTQ Orbitrap XL™组合式质谱仪。
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