〓疯子哥〓
第1楼2007/10/12
原文检索:
Copyright © 2007 Cell Press. All rights reserved.
Cell Stem Cell, Vol 1, 458-469, 11 October 2007
Stem Cell Aging Is Controlled Both Intrinsically and Extrinsically in the Drosophila Ovary
Article
Stem Cell Aging Is Controlled Both Intrinsically and Extrinsically in the Drosophila Ovary
Lei Pan,1,2 Shuyi Chen,1,3 Changjiang Weng,1 Gerald Call,1,5 Dongxiao Zhu,1,4 Hong Tang,2 Nian Zhang,1 and Ting Xie1,3,
1 Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA
2 Center for Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, 15 Da Tun Road, Beijing 100101, China
3 Department of Anatomy and Cell Biology, University of Kansas School of Medicine, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
4 Department of Biostatistics, University of Kansas School of Medicine, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
5 Department of Pharmacology, Arizona College of Osteopathic Medicine, Midwestern University, 19555 North 59th Avenue, Glendale, AZ 85308, USA
Corresponding author
〓疯子哥〓
第2楼2007/10/12
Summary
It is widely postulated that tissue aging could be, at least partially, caused by reduction of stem cell number, activity, or both. However, the mechanisms of controlling stem cell aging remain largely a mystery. Here, we use Drosophila ovarian germline stem cells (GSCs) as a model to demonstrate that age-dependent decline in the functions of stem cells and their niche contributes to overall stem cell aging. BMP signaling activity from the niche significantly decreases with age, and increasing BMP signaling can prolong GSC life span and promote their proliferation. In addition, the age-dependent E-cadherin decline in the stem cell-niche junction also contributes to stem cell aging. Finally, overexpression of SOD, an enzyme that helps eliminate free oxygen species, in either GSCs or their niche alone can prolong GSC life span and increase GSC proliferation. Therefore, this study demonstrates that stem cell aging is controlled extrinsically and intrinsically in the Drosophila ovary.
〓疯子哥〓
第3楼2007/10/12
中国科学院第四批海外评审专家信息
解 廷(Xie Ting)
性别: 男
出国时间: 1991
最后学位: 博士学位
获得学位的时间: 1996
最后获得学位的单位: Rutgers University,New Jersey, USA
现职单位: 斯德尔(Stowers)医学院
现任职务(英文): Associate Professor
现任职务(中译): 副教授
从事的学科领域: 生命科学与生物技术
专业: 细胞生物学
主要研究方向: 干细胞
现在进行的研究课题: Genetic and molecular studies on the mechanisms controlling stem cell self-renewal,proliferation and differentiation in Drosophila and mice
现单位通讯地址: 1000 East 50 Street Kansas City,MO 64110
传真: 816-916-2029
E-mail:tgx@stowersinstitute.org
所在国家/州/省/城市: 美国 , Kansas City
代表性学术论文/论著:
1.Xiaoqing Song,Marco D.Wong,Eihachiro Kawase,Rongwen Xi,Bee C.Ding,John J.McCarthy and Ting Xie(2004).BMP signals from niche cells directly repress transcription of a differentiation-promoting gene,bag of marbles,in germline stem cells in the Drosophila ovary.Development131,1353-1364.
2.Eihachiro Kawase Marco D.Wong,Bee C.Ding and Ting Xie(2004).Two BMP-like signaling pathways directly control the maintenance of germline stem cells in the Drosophila testis.Development 131,1365-1375.
3.Xiaoqing Song and Ting Xie(2003).The wingless signaling is required for the maintenance and proliferation of somatic stem cells in the Drosophila ovary. Development 103,3259-3268.
4.Chun-Hong Zhu and Ting Xie(2003).Clonal expansion of ovarian germline stem cells during niche formation in Drosophila.Development 130,2579-2588.
5.Xiaoqing Song and Ting Xie(2002).DE-cadherin-mediated cell adhesion is essential for maintaining somatic stem cells in the Drosophila ovary.PNAS,99,14813-14818.
6.Xiaoqing Song,Chun-Hong Zhu,Chuong Doan and Ting Xie(2002).Germline stem cells anchored by adherens junctions in the Drosophila ovary niches.Science 296,1855-1857.
7.Ting Xie and Allan C.Sprading(2001).The Drosophila ovary:an in vivo stem cell system.Stem Cell Biology (Cold Spring Harbor Monograph Series),D.R.Marshak,R.L.Gardner and D.Gottlied,eds.,129-148.
8.Ting Xie and Allan C.Sprading(2000).A niche maintaining germ line stem cells in the Drosophila Ovary.Science 290,328-330.
9.Ting Xie and Allan C.Sprading(1998).decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary.Cell 94,251-260.
10.Ting Xie,Alyce L.Finelli and Richard W.Padgett(1994).The Drosophila saxophone gene:a serine-threonine kinase receptor of TGF-β superfamily.Science 263,1756-1759.
〓疯子哥〓
第4楼2007/10/12
获成果/奖励情况:
1. 2003年,M.R.and Evelyn Hudson Foundation,M.R.and Evelyn Hudson Foundation prize.
2. 1992-1995年,Rutgers University,Busch Predoctoral Fellowship
3. 1984-1987年,Beijing Agricultural University,Highest Academic Honor.
与国内学术交流等情况:
I have visiteed Institute of Zoology of Chinese Academy of Sciences for seminars and have also carried out scientific changes.I have been helping Dr.Duan to train graduate students on stem cell research and have planned to do some collaborative research on stem cells.
I have visited Institute of Microbiology of Chinese Academy of Sciences and College of Life Sciences of Beijing University for scientific exchanges.
Iwas invited to be a plenary speaker in The First International Symposium on Glaucoma(Beijing)in the spring of 2004.
I have been invited to speak in the coming 10 SCBA International Symposium(Beijing).
主要学术贡献创新思想:
I(as a postdoctoral fellow)have first demonstrated that stem cells are controlled by their microenvironments or niches(Xie and Spradling,Science,2000).This niche concept has changed the way scientists study stem cells.
My laboratory has first identified cadherin as "glue"for anchoring stem cells in their niches(Song et al.,Science,2002;Song and Xie,PNAS,2002).It is clear by now that this is a general mechanism for anchoring stem cells in their niche.
Mlaboratory has identified important growth factors that are produced by niche cells and are essential for stem cell self-renewal and proliferation(Song and Cie,Development,2003;Song et al.Development,2004;Kawase ed al.Development,2004).The identification of those growth factors is critical for understanding stem cell biology and using stem cells as therapeutic tools.
My laboratory has recently discovered that multiple stem cells in one niche can derive from one precursor cell(Zhu and Xie,Development,2003).This discovery provides important insight into how empty niches are re-populated in stem cell therapy.
斯托瓦斯研究所(Stowers Institute)
位于密苏里州堪萨斯市,这个60万平方尺的校园里集合了这种先进设施,主要致力于通过进行细胞基本生命过程的研究,寻求尖端技术更有效的预防和治疗疾病。Stowers Institute由Jim Stowers和Virginia Stowers这两位癌症幸存者捐赠的2亿美元资助成立。