yilai1002 2009/05/20
[img]http://www.instrument.com.cn/bbs/images/affix.gif[/img][url=http://www.instrument.com.cn/bbs/download.asp?ID=151117]3 High-Pressure liquid chromatographic analysis of penicillin G potassium and its degradation products[/url]
大陆 2009/05/25
1 ok. 2 too old, so no e-fulltext. [img]http://www.instrument.com.cn/bbs/images/affix.gif[/img][url=http://www.instrument.com.cn/bbs/download.asp?ID=151847]A nuclear magnetic resonance study of the degradation of penicillin G in acidic solution---PerkinTrans.pdf[/url]
sdwalker 2009/05/18
Paper J. Chem. Soc., Perkin Trans. 2, 1979, 86 - 90, DOI: 10.1039/P29790000086 -------------------------------------------------------------------------------- A nuclear magnetic resonance study of the degradation of penicillin G in acidic solution Jaques P. Degelaen, Spiros L. Loukas, James Feeney, Gordon C. K. Roberts and Arnold S. V. Burgen -------------------------------------------------------------------------------- N.m.r. methods have been used to study the degradation of benzylpenicillin at pH 2.5 and 37 °C. After 100 min three major reaction products, penamaldic acid, penillic acid, and penicilloic acid were detected. By measuring the extent of deuteriation at the C-6 position (the reaction was conducted in DCl–D2O solution) it was shown that most of the penillic acid (65%) and penicilloic acid (70%) had not been formed via a penicillenic acid type intermediate as previously suggested. Eventually the three initial products degraded into penilloic acid without any further deuteriation (estimated from the deuteriation at the C-6 position of penilloic acid): thus penillic acid and penicilloic acid do not degrade via a penicillenic acid intermediate. No penicillamine, benzylpenilloaldehyde, or related products were detected.
hstudent 2009/05/19
第3个应为1975年的 High-Pressure liquid chromatographic analysis of penicillin G potassium and its degradation products Journal of Pharmaceutical Sciences Volume 64, Issue 8, Date: August 1975, Pages: 1384-1386 Jean M. Blaha, Adelbert M. Knevel, Stanley L. Hem
sdwalker
第1楼2009/05/18
Paper
J. Chem. Soc., Perkin Trans. 2, 1979, 86 - 90, DOI: 10.1039/P29790000086
--------------------------------------------------------------------------------
A nuclear magnetic resonance study of the degradation of penicillin G in acidic solution
Jaques P. Degelaen, Spiros L. Loukas, James Feeney, Gordon C. K. Roberts and Arnold S. V. Burgen
--------------------------------------------------------------------------------
N.m.r. methods have been used to study the degradation of benzylpenicillin at pH 2.5 and 37 °C. After 100 min three major reaction products, penamaldic acid, penillic acid, and penicilloic acid were detected. By measuring the extent of deuteriation at the C-6 position (the reaction was conducted in DCl–D2O solution) it was shown that most of the penillic acid (65%) and penicilloic acid (70%) had not been formed via a penicillenic acid type intermediate as previously suggested. Eventually the three initial products degraded into penilloic acid without any further deuteriation (estimated from the deuteriation at the C-6 position of penilloic acid): thus penillic acid and penicilloic acid do not degrade via a penicillenic acid intermediate. No penicillamine, benzylpenilloaldehyde, or related products were detected.
大陆
第5楼2009/05/25
1 ok.
2 too old, so no e-fulltext.
A nuclear magnetic resonance study of the degradation of penicillin G in acidic solution---PerkinTrans.pdf
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