【Abstract】 OBJECTIVE To establish a HPLC method for the determination of nizatidine in human plasma.METHODS Nizatidine was extracted from human plasma using chloroform after basified with salting-out agent,and then separated on a Diamonsil C 18 column ( 200 mm × 4.6 mm, 5 μm).The mobile phase consisted of water( 0.1 mol · L -1 ammonium acetate)-methanol(60∶40 ). Ranitidine was used as the internal standard and the wavelength of detection was set at 320 nm.RESULTS The linear range was 20- 6 000 μg·L -1(r = ... 更多还原 【关键词】 尼扎替丁; 高效液相色谱法; 测定; 【Key words】 nizatidine; HPLC; determination;