Reviewer #: This is a generally clearly written manuscript that is of some interest. However, the discussion section is rather difficult to follow, and needs quite extensive revision. The fact that only one wild type strain of ......was tested is a weakness, because it gives the reader little assurance that the mutant strains truly had different characteristics.Reviewer #2: -The paper has several spelling and grammatical mistakes. some are summarized below接下来就是审稿专家给出具体的错误以及他给改的正确写法。在文章中做了相应修改，应该如何回复？
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