快乐的小马 2007/01/18
不好意思,我没有具体查NSTL的,以为NSTL会有99年的呢。 关于费用,我又仔细查了一下,只有CSDL的扫描是院内每页五毛钱,院外每页1元。NSTL原文传递的话,每页扫描是一元。 中国医科院图书馆是扫描每页1.5元,解放军医学图书馆是扫描每页1元。 所以你的花费应该是十元左右。 先按照楼上说的向作者要试试,这招省钱啊,呵呵。
gpdx 2007/01/24
楼主的文献寻到了没?
快乐的小马
第1楼2007/01/18
我在网上只能看到这些东西,供你参考:
The Low Potential for Drug Interactions with Zanamivir
Authors: Daniel M.J.1; Barnett J.M.1; Pearson B.A.1
Source: Clinical Pharmacokinetics, Volume 36, Supplement 1, 1999, pp. 41-50(10)
Publisher: Adis International
Key: - Free content - New Content - Subscribed Content - Free Trial Content
Abstract:
Objective: The objective of this study was to assess the potential of zanamivir, a specific inhibitor of influenza A and B virus neuraminidase, to interact with other coadministered therapies in the clinical setting.
Design: Potential interactions with zanamivir were examined in a series of in vitro and in vivo model systems.
Interventions: The expression of microsomal cytochrome P450 (CYP) isoenzymes was examined after daily treatment of rats with intravenous zanamivir. The ability of zanamivir to inhibit the metabolism of CYP probe substrates was studied in human liver microsomes. The binding of zanamivir to human and animal red blood cell fractions and plasma proteins was measured. Finally, the effect of commonly coadministered drugs on the ability of zanamivir to inhibit viral replication in vitro was tested.
Results: Zanamivir had no effect on the expression of microsomal CYP isoenzymes after daily intravenous treatment of rats with zanamivir 1, 9 or 90 mg/kg for 5 weeks. Zanamivir at concentrations up to 500 µmol/L (150 mg/L) had no effect on the metabolism of the CYP probe substrates bufuralol, chlorzoxazone, coumarin, ethoxyresorufin, mephenytoin, midazolam, phenacetin and tolbutamide by human liver microsomes. The binding of zanamivir 0.05 to 10 mg/L to human, dog and rat red blood cells and plasma proteins was low. The in vitro potency of zanamivir against influenza virus in Madin Darby canine kidney cells was not adversely affected by aspirin (acetylsalicylic acid) 1.2 mmol/L, paracetamol (acetaminophen) 6.6 mmol/L, ibuprofen 243 µmol/L, phenylephrine 6 mmol/L, oxymetazoline 380 µmol/L, promethazine 35 µmol/L and co-amoxiclav (amoxicillin-clavulanic acid) 1.66 mmol/L.
Conclusions: These data suggest the following:
there is no theoretical basis for expecting metabolic interactions between zanamivir and other coadministered compounds;
zanamivir is unlikely to interact with coadministered compounds that are protein bound; and
commonly coadministered drugs will not interfere with the antiviral activity of zanamivir in vivo.
Although none of these in vitro or in vivo studies were exhaustive, and although none were performed in humans, all the data are consistent with zanamivir having a very low potential for interactions with coadministered drugs in the clinical setting.
Keywords: Zanamivir, drug-interactions; Drug-interactions; Antivirals, drug-interactions; Zanamivir, pharmacokinetics; Plasma-protein-binding; Analgesics, drug-interactions; Decongestants, drug-interactions; Antihistamines, drug-interactions; Antibacterials, drug-interactions
Language: English
Document Type: Original article
Affiliations: 1: Glaxo Wellcome Research and Development, Ware, England *
The full text article is available for purchase
$54.95
快乐的小马
第2楼2007/01/18
在http://union.csdl.ac.cn中查到的各馆馆藏信息如下,你看看方便去那里要吧。
题名和责任者说明 : Clinical Pharmacokinetics
出版 : New York : ADIS Press, 1976-
电 子 资 源 链 接 ( 2 条)
电子资源链接: http://search.epnet.com/direct.asp?db=a3...
电子资源链接: http://corrado.ingentaselect.com/vl=1644...
9 家成员馆有收藏,点击查看详细馆藏信息
收藏单位 收藏年卷期
中国科学院上海生命科学信息中心 v.1-10 1976-85
中国科学院上海药物研究所图书情报室 v.1-29 1976-95
大连医科大学图书馆 v.11- 1986- (lacks v.38,no.3 2000)
复旦大学图书馆 v.41- 2002-
浙江大学湖滨校区(医学分馆) v.4-29 1979-1995 v.34- 1998-
中国医学科学院图书馆 v.8- 1983-
解放军医学图书馆 v.2-44 1977-2005
第二军医大学药学院图书馆 v.22-29 1991-95
南京军区南京总医院医学图书馆 v.11-41 1986-2002
ISBN/ISSN : 0312-5963
原版刊号 : 633UA52
卷期 : V.1,no.1(1976)-
中图分类号 : R969.1
科图分类号 : 63.312
另外,NSTL上也应该有,你自己再去看看吧。如果你要原文传递的话,估计应该不到五块钱就能获得。
或者你是否认识中科大的人?倒是可以从他们那里直接获得电子的,他们买了这个数据库。