谢谢zzwbj抽出宝贵的时间与我共享这台仪器。
我查了他们的cryodetector资料，发表一下我的看法：
由于低温检测器是在接近于绝对零度（T≤0.4K）的条件下操作的，所以超导膜（superconducting film）中的电子以库柏对形式存在，库柏对的形成导致超导体能谱的改变，为了激发处于超导态的电子系统，至少要破坏一个库柏对，即至少需要一份等于库柏对结合能的能量。粒子撞击到超导膜上产生声子（phonons）（lattice vibrations），声子反过来破坏库柏对使其成为自由电子，这种电子穿隧道通过绝缘的氧化物层，形成可测的电流。因而cyrodetector检测器是根据粒子的能量来检测，对于分子的大小没有影响，更不存在检测器饱和的问题。

或许原文对你来说更有帮助，发给你的邮件里有图示。
以下是原文：

How STJs work

Understanding STJs is not difficult. The detector is simply a junction between 2 superconducting films, separated by an ultra-thin oxide layer. Because the detector temperature is close to absolute zero,electrons exist in their superconductive stage as Cooper pairs.

Impinging particles generate phonons (lattice vibrations), which in turn back Cooper pairs into free electrons. Such electrons tunnel through the insulating oxide layer and thus cause a measurable current over the junction. The current is directly proportional to the (kinetic) energy deposited by the original impact. As the phonons diffuse, the Cooper pairs are restored and current ceases to flow. Clearly, every impact transfers energy to the junction and generates a current, hence the detector is 100% efficient. The kinetic energy of an accelerated ion is the same regardless of its mass, hence the current produced by the detector is also independent of its mass.

对于你说的离子化效率低的问题，或许下面的原文对你能够解释的比较清楚：

The development of mass independent detection has two key implications in mass spectrometry. The first is realization of high sensitivity at very high mass, allowing development of new high mass applications in analysis of proteins, nucleic acids and polymers. The second is detection of ions with equal efficiency at all masses, reflecting the true relative ion yield. Complete spectra are viewed, rather than spectra biased toward low mass components. Relative ionization efficiencies of different compounds can be determined and more accurate quantitation within mixtures becomes possible.

又找到几个cryodetector的资料—cryodetector的创始人。

http://www.genspec.ch

专家.厉害!

gop同学说得好呀，小弟最近也在钻研这个，收获颇多，我想低温检测技术确实是一个很大的革新。。。。。。，各国科学家也会不断用实验来验证的。。。

MALDI的主要问题，比如说不好定量、质量歧视，这些并非仅与检测器有关。比如说，A、B两种物质含量相当，但A对MALDI的响应高，易于离子化，很显然，检测到的信号A高；大分子的化合物由于飞行速度慢，在飞行管中会损失一部分，更为关键的是，大分子的化合物在MALDI中离子化困难，数目相对小分子化合物要少的多。问题在前面已经出现，单凭一个检测器怎么能解决这所有的问题？

detection of ions with equal efficiency at all masses, reflecting the true relative ion yield——注意这句话，说得很对，它检测到了MALDI源当中所产生的所有离子，但是在源内就已经出现了问题...
当然，它对能够到达监测器的离子毫无歧视的检测，很是有用，一定有发展前途的。

是呀，没错，确实说到了本质，诚恳再请教一下，源内出现的问题是所有maldi－tof都会出现的吗？？多谢了。。。。。。。

到目前为止，我没有看到其它的说法，应该是的。