MAbPac RP LC 色谱柱

MAbPac RP LC 色谱柱

使用新型 Thermo Scientific? MAbPac? RP 色谱柱对单克隆抗体 (mAb)、片段、变体、抗体药物标记物 (ADC)、聚乙二醇蛋白质和双特异蛋白质进行高性能反相 (RP) HPLC 和 LC/MS 表征。 这些色谱柱具有出色的分离度、长使用寿命和低残留。 表面化学结构、粒径和孔径已经过优化，适用于更高分离度的分离。

描述

与RP 条件下在 HPLC 和 MS 中使用的有机溶剂兼容

• 树脂基于疏水性超大孔 4μm 聚合物颗粒

• 在极端 PH（0 ~ 14）和高温（高达 110 °C）条件下保持稳定

高柱效，低残留

• 1,500 ? 大孔径聚合树脂；

• 高效分离蛋白质分子，超低残留

设计用于反相生物分子 LC 和 LC/MS 分离

• 卓越的分离能力，适用于单克隆抗体及相关物质

• 高柱效，低残留

• 出色的 MS 兼容性

• 广泛的操作 pH 范围： 0 至 14

• 高温稳定性：高达 110 °C

• 高通量

MAbPac RP LC 色谱柱

订货信息：

MAbPac RP Column for Monoclonal Antibody Reversed-phase Separations

The Thermo Scientific? MAbPac? RP column is a reverse phase (RP) liquid chromatography column designed for mAb characterization, including the separation of mAb and variants, light chain (LC) and heavy chain (HC), Fc and Fab fragments, scFc and F(ab')2 fragments, using LC/UV or LC/MS. The unique column chemistry provides excellent
performance under a broad range of pH, temperature, and mobile phase composition.

Product Highlights
? Superior resolution power for monoclonal antibodies and related substances
? High efficiency with low carry-over
? Excellent MS compatibility
? Wide operating pH range: 0–14
? High temperature stability: up to 110 °C
? High throughput

The MAbPac RP The stationary phase is fully compatible with mass spectrometry friendly organic solvent such as acetonitrile and isopropanol, as well as low pH eluents containing trifluoroacetic acid or formic acid. The MAbPac RP is based on wide-pore 4 μm polymer particles that are stable at extreme pH (0–14) and high temperature (up to 110 °C). The wide-pore size of polymeric particles enables efficient separation of protein molecules with low carry-over.

Data Sheets
	MAbPac RP Column Product Specifications

Manuals
	MAbPac RP Columns Quick Start
	MAbPac RP Columns Manual

Applications
	Fast Analysis of Therapeutic Monoclonal Antibody Fragments Using a Supermacroporous, Reversed-Phase Chromatography Column
	Reversed-Phase Separation of Intact Therapeutic Antibodies Using the Vanquish Flex UHPLC System

Posters
	Comprehensive Characterization of Site-specific Engineered Antibody Drug Conjugate by Orbitrap Mass Spectrometer
	Fast Analysis of Therapeutic Monoclonal Antibodies, Fragments, and Oxidation Variants Using a Super-Macro Porous Reversed-Phase Column Coupled with an Orbitrap Mass Spectrometer
	Characterization of Monoclonal Antibodies Oxidation Variants Using Middle-down Approach and Hydrogen/Deuterium Exchange Mass Spectrometry