锤子
Amphetamine-type stimulants are a class of illicit drug that constitutes a worldwide problem to which intelligence agencies, first responders and law enforcement are tasked with identifying them in unknown samples. We report on the development of a graphene oxide (GO)-cationic multi-shaped gold nanoparticle (AuNP)-hemin hybrid nanozyme as a new biomimetic catalytic-induced aptamer-based colorimetric biosensor platform for amphetamine (AMP) and methamphetamine (MAMP). GO was electrostatically bonded to cationic multi-shaped cetyltrimethylammonium bromide (CTAB)-AuNPs to form a GO-CTAB-AuNP hybrid nanozyme exhibiting enhanced catalytic activity in the presence of hemin. The binding of an MNS 4.1 anticocaine DNA aptamer on the GO-CTAB-AuNP-hemin nanozyme assembly and the subsequent catalytic oxidation by 3,3,5,5-tetramethylbenzidine in the presence of H2O2 ensured that the colorimetric reaction was tuned to selectively detect AMP and MAMP with high sensitivity.
打开失败或需在电脑查看,请在电脑上的资料中心栏目,点击"我的下载"。建议使用手机自带浏览器。