Proteomic Interrogation of Primary Insulin-secreting Pancreatic β-cells

2020/09/21   下载量： 0 次

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应用领域 生物产业
检测样本 其他
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The combination of integrated ion mobility with warp-speed MS/MS acquisition on the timsTOF Pro paves the way for deep, molecular level understanding of β-cell physiology and potential new targetable pathways for diabetes.

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In this work we leveraged the analytical performance of the timsTOF Pro to identify expres-

sion of low-level enzymes for the first time in primary insulin-secreting beta cells (β-cells). We found that these proteins are critical, functional components of key metabolic pathways which

can support β-cell survival under inflammatory stress, an emerging disease etiology of diabetes. Confirmation that these factors are present and functional specifically in pancreatic β-cells points to new therapeutic avenues for human diabetes.

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布鲁克·道尔顿(Bruker Daltonics)
金牌会员 丨 第22年
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