预防类生物药品含量测定>色谱法检测 | LC/MS Analysis of the Monoclonal Antibody Rituximab Using the Q Exactive Benchtop Orbitrap Mass Spectrometer-赛默飞色谱与质谱

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应用领域	化药/中药/生物制药
检测样本	预防类生物药品
检测项目	含量测定>色谱法
参考标准	无

In this study, a workflow is presented that combines fast chromatography, using two sizes of monolithic columns,and high resolution Orbitrap mass spectrometry of intact,as well as reduced, rituximab, sequence verification by AIF,and multiplexed HCD top-down fragmentation,supplemented by a bottom-up approach.

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In this study, a workflow is presented that combines fast chromatography, using two sizes of monolithic columns,and high resolution Orbitrap mass spectrometry of intact,as well as reduced, rituximab, sequence verification by AIF,and multiplexed HCD top-down fragmentation,supplemented by a bottom-up approach.

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