null检测 | Fabrication and in vitro drug release study of microsphere drug delivery systems based on amphiphilic poly-,-[N-(2-hydroxyethyl)-l-aspartamide]-g-poly (l-lactide) graft copolymers-北京东方德菲仪器有限公司

方案摘要

方案下载

应用领域
检测样本
检测项目
参考标准

Biodegradable amphiphilic graft copolymers with different compositions were synthesized by grafting poly(l-lactide) (PLLA) sequences onto a water-soluble poly-,-[N-(2-hydroxyethyl)-l-aspartamide] (PHEA) backbone. The critical micelle concentration (CMC) of the graft polymers was determined by fluorescence probe technique. Using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay, the graft polymers were proved to have low cytotoxicity. Based on the specific physicochemical property of the graft copolymers, submicron sized microsphere drug delivery systems were prepared by a very convenient “ultrasonic dispersion method”, which did not involve toxic organic solvents. The drug-loaded microspheres had a regular spherical shape with a narrow size distribution. A hydrophobic drug, prednisone acetate, was encapsulated into polymeric microspheres and the in vitro drug release was studied.

方案下载

上一篇改进的Washburn法研究矿物岩石颗粒的表面润湿性

下一篇中国客户在国际期刊上发表的文章：Determination of Dynamic Interfacial Tension and Its Effect on Droplet Formation in the T-Shaped Microdispersion Process

文献贡献者

北京东方德菲仪器有限公司

银牌会员丨第21年

查看全部资料