Lipophilicity Profiles: Theory and Measurement

2007/10/12   下载量: 91

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Lipophilicity represents the affinity of a molecule or moiety for a lipophilic environment. It is commonly measured by its distribution behavior in a biphasic system, either liquid-liquid (e.g.,partition coefficient in octanol/ water) or by chromatographic methods [1]. Knowledge of lipophilicity is used in a variety of methods that may predict absorption and other transport properties of drug molecules in the human body.

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