null检测 | PH-metric log P 11. pKa determination of water-insoluble-凯戈纳斯仪器商贸（上海）有限公司

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The apparent acid dissociation constants (psKa) of two water-insoluble drugs, ibuprofen and quinine, were　determined pH-metrically in acetonitrile–water, dimethylformamide–water, dimethylsulfoxide–water, 1,4-dioxane–　water, ethanol–water, ethylene glycol–water, methanol–water and tetrahydrofuran–water mixtures. A glass electrode　calibration procedure based on a four-parameter equation (pHaSpcHjH[H]jOH[OH]) was used to obtain　pH readings based on the concentration scale (pcH). We have called this four-parameter method the Four-Plus™　technique. The Yasuda–Shedlovsky extrapolation (psKalog [H2O]A:oB) was used to derive acid dissociation　constants in aqueous solution (pKa). It has been demonstrated that the pKa values extrapolated from such solvent–water mixtures are consistent with each other and with previously reported measurements. The suggested　method has also been applied with success to determine the pKa values of two pyridine derivatives of pharmaceutical　interest. © 1999 Elsevier Science B.V. All rights reserved.

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