null检测 | Part IV. Water-insoluble pyridine derivatives-凯戈纳斯仪器商贸（上海）有限公司

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A multiwavelength spectrophotometric (WApH) titration method for determination of acid dissociation　constants (p Κa　values) of ionisable compounds developed previously was applied in the case of pyridine　derivatives of pharmaceutical interest. Specifically, UV absorption spectra of the drug solution are acquired in　the course of a pH-metric titration using an optical device based on a fibre optics dip probe, a light source and diode array detector. Target factor analysis was applied to deduce the p Κa　values from the spectral data　recorded at different pH. Using this technique, the p Κa　values of six pyridine derivatives were determined　successfully. It was demonstrated that the WApH technique in this case outperforms conventional pH-metric　methods with respect to the measurement of p Κa　values of the sparingly water soluble samples reported in this　study. 1999 Elsevier Science B.V. All rights reserved.

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