资料摘要
资料下载Most excitatory synapses terminate on dendritic spines. Spines vary in size, and their volumes are proportional to the area of the postsynaptic density (PSD) and synaptic strength. PSD-95 is an abundant multi-domain postsynaptic scaffolding protein that clusters glutamate receptors and organizes the associated signaling complexes. PSD-95 is thought to determine the size and strength of synapses. Although spines and their synapses can persist for months in vivo, PSD-95 and other PSD proteins have shorter half-lives in vitro, on the order of hours. To probe the mechanisms underlying synapse stability, we measured the dynamics of synaptic PSD-95 clusters in vivo. Using two-photon microscopy, we imaged PSD-95 tagged with GFP in layer 2/3 dendrites in the developing (postnatal day 10–21) barrel cortex. A subset of PSD-95 clusters was stable for days. Using two-photon photoactivation of PSD-95 tagged with photoactivatable GFP (paGFP), we measured the time over which PSD-95 molecules were retained in individual spines. Synaptic PSD-95 turned over rapidly (median retention times sr ; 22–63 min from P10–P21) and exchanged with PSD- 95 in neighboring spines by diffusion. PSDs therefore share a dynamic pool of PSD-95. Large PSDs in large spines captured more diffusing PSD-95 and also retained PSD-95 longer than small PSDs. Changes in the sizes of individual PSDs over days were associated with concomitant changes in PSD-95 retention times. Furthermore, retention times increased with developmental age (sr ; 100 min at postnatal day 70) and decreased dramatically following sensory deprivation. Our data suggest that individual PSDs compete for PSD-95 and that the kinetic interactions between PSD molecules and PSDs are tuned to regulate PSD size.
VENTEON PULSE ONE
简介:Venteon <8 fs 超快雷射震荡器 德国Venteon 专门从事于生产高质量光学镀膜,使其能符合不管是工业界或学术界非常严格的要求,因自身的设计能力,使其能设计一系列高规格镜片,如Edge Filter、Bandpass Filter、GVD-Mirror、非线性晶体和高功率雷射镜片等。 此外,提供各式超短脉冲激光(<8fs),作为高阶激光领域之研究.
VENTEON PULSE FOUR (SPIDER)_v2.2
简介:Venteon <8 fs 超快雷射震荡器 德国Venteon 专门从事于生产高质量光学镀膜,使其能符合不管是工业界或学术界非常严格的要求,因自身的设计能力,使其能设计一系列高规格镜片,如Edge Filter、Bandpass Filter、GVD-Mirror、非线性晶体和高功率雷射镜片等。 此外,提供各式超短脉冲激光(<8fs),作为高阶激光领域之研究.
fox_vcsel_data_sheet
简介:AEHR 老化测试系统 1. 老化测试系统ABTS-L 1) 高可靠性老化测试系统 2) 可作环境测试的同时进行Functional Test 3) 可同时支持Logic和Memory类IC老化测试;最大可Up to 72slots 4) 1个Driver Board对应一个Zone 5) 可同时测试多种产品,最大可有320 I/0Channel;N+1的模块化电源设计, 如果其中任一电源损坏,备用电源自动切换工作,独立的可配置的CPB电源板设计 6) 可提供纯净的电源供给BIB给客户应用,同时还非常省电, 电路板和电源都可以进行热拔插更换 7) 有High power类应用配置 8) 可客制化配置 9) 可支持高达100瓦/Device,72组/BIB电源供给客户应用,且开放接口可供客户自行制作BIB! 2. 老化测试系统ABTS-Mini 配置同ABTS-L,应用于应用量比较少的场合 例如实验室,标准6Slots,可Up to 12Slots 3. 老化测试系统ABTS-Double Mini 配置同ABTS-Mini 为两台MINI叠加 有2个温度区,应用于多温度需求 标准12slots,可Up to 24slots.
FOX-15 revBFP Datasheet
简介:AEHR 老化测试系统 1. 老化测试系统ABTS-L 1) 高可靠性老化测试系统 2) 可作环境测试的同时进行Functional Test 3) 可同时支持Logic和Memory类IC老化测试;最大可Up to 72slots 4) 1个Driver Board对应一个Zone 5) 可同时测试多种产品,最大可有320 I/0Channel;N+1的模块化电源设计, 如果其中任一电源损坏,备用电源自动切换工作,独立的可配置的CPB电源板设计 6) 可提供纯净的电源供给BIB给客户应用,同时还非常省电, 电路板和电源都可以进行热拔插更换 7) 有High power类应用配置 8) 可客制化配置 9) 可支持高达100瓦/Device,72组/BIB电源供给客户应用,且开放接口可供客户自行制作BIB! 2. 老化测试系统ABTS-Mini 配置同ABTS-L,应用于应用量比较少的场合 例如实验室,标准6Slots,可Up to 12Slots 3. 老化测试系统ABTS-Double Mini 配置同ABTS-Mini 为两台MINI叠加 有2个温度区,应用于多温度需求 标准12slots,可Up to 24slots.
FOX-1 revCFP
简介:AEHR 老化测试系统 1. 老化测试系统ABTS-L 1) 高可靠性老化测试系统 2) 可作环境测试的同时进行Functional Test 3) 可同时支持Logic和Memory类IC老化测试;最大可Up to 72slots 4) 1个Driver Board对应一个Zone 5) 可同时测试多种产品,最大可有320 I/0Channel;N+1的模块化电源设计, 如果其中任一电源损坏,备用电源自动切换工作,独立的可配置的CPB电源板设计 6) 可提供纯净的电源供给BIB给客户应用,同时还非常省电, 电路板和电源都可以进行热拔插更换 7) 有High power类应用配置 8) 可客制化配置 9) 可支持高达100瓦/Device,72组/BIB电源供给客户应用,且开放接口可供客户自行制作BIB! 2. 老化测试系统ABTS-Mini 配置同ABTS-L,应用于应用量比较少的场合 例如实验室,标准6Slots,可Up to 12Slots 3. 老化测试系统ABTS-Double Mini 配置同ABTS-Mini 为两台MINI叠加 有2个温度区,应用于多温度需求 标准12slots,可Up to 24slots.
相关产品
关注
拨打电话
留言咨询